Science | Nature | Cell | View More
Natural Products
Chamigrenal
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Chamigrenal
Price: $268 / 5mg
CAS No.: 19912-84-6
Catalog No.: CFN90967
Molecular Formula: C15H22O
Molecular Weight: 218.33 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Oil
Source: The fruits of Schisandra chinensis.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $187.6 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Universidad Veracuzana (Mexico)
  • Helmholtz Zentrum München (Germany)
  • University of Zurich (Switzerland)
  • Monash University Sunway Campus (Malaysia)
  • University of Minnesota (USA)
  • Medical University of Gdansk (Poland)
  • University of Maryland (USA)
  • Cornell University (USA)
  • Stanford University (USA)
  • Calcutta University (India)
  • Universitas islam negeri Jakarta (Indonesia)
  • More...
Package
Featured Products
Baicalin

Catalog No: CFN99111
CAS No: 21967-41-9
Price: $40/20mg
Beta-mangostin

Catalog No: CFN99723
CAS No: 20931-37-7
Price: $218/10mg
Procyanidin B3

Catalog No: CFN99559
CAS No: 23567-23-9
Price: $238/10mg
Kaempferol 7-O-rhamnoside

Catalog No: CFN96224
CAS No: 20196-89-8
Price: $338/10mg
gamma-Mangostin

Catalog No: CFN98396
CAS No: 31271-07-5
Price: $70/20mg
Isofraxidin

Catalog No: CFN90181
CAS No: 486-21-5
Price: $40/20mg
Vomifoliol

Catalog No: CFN98245
CAS No: 23526-45-6
Price: $ /
Grossamide

Catalog No: CFN97672
CAS No: 80510-06-1
Price: $318/5mg
3,4,5-Tricaffeoylquinic acid

Catalog No: CFN90238
CAS No: 86632-03-3
Price: $318/5mg
Zeaxanthin

Catalog No: CFN90234
CAS No: 144-68-3
Price: $ / mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 macrophages. Chamigrenal shows platelet-activating factor antagonistic activity and the IC(50) value of 1.2x10(-4) M; it also exhibits weak cytotoxicity towards MCF-7 cells(IC50=30.50 uM).
Targets: NO | PGE | NOS | COX | EGFR | PAFR
In vitro:
Planta Med. 2014 Jun;80(8-9):655-61.
Inhibitory effects of β-chamigrenal, isolated from the fruits of Schisandra chinensis, on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 macrophages.[Pubmed: 24871206 ]
Much is known about the bioactive properties of lignans from the fruits of Schisandra chinensis. However, very little work has been done to determine the properties of sesquiterpenes in the fruits of S. chinensis.
METHODS AND RESULTS:
The aim of the present study was to investigate the anti-inflammatory potential of new sesquiterpenes (β-Chamigrenal, β-chamigrenic acid, α-ylangenol, and α-ylangenyl acetate) isolated from the fruits of S. chinensis and to explore their effect on macrophages stimulated with lipopolysaccharide. Of these four sesquiterpenes, β-Chamigrenal most significantly suppressed lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 macrophages (47.21 ± 4.54 % and 51.61 ± 3.95 % at 50 μM, respectively). Molecularly, the inhibitory activity of β-Chamigrenal on nitric oxide production was mediated by suppressing inducible nitric oxide synthase activity but not its expression. In the prostaglandin E2 synthesis pathway, β-Chamigrenal prevented the upregulation of inducible microsomal prostaglandin E synthase-1 expression after stimulation with lipopolysaccharide. Conversely, β-Chamigrenal had no effect on the expression and enzyme activity of cyclooxygenase-2. In addition, the expression of early growth response factor-1, a key transcription factor of microsomal prostaglandin E synthase-1 expression, was inhibited by β-Chamigrenal.
CONCLUSIONS:
These results may suggest a possible anti-inflammatory activity of β-Chamigrenal which has to be proven in in vivo experiments.
Arch Pharm Res. 1997 Dec;20(6):633-6.
Platelet-activating factor antagonistic activity and(13)C NMR assignment of pregomisin and chamigrenal fromSchisandra chinensis.[Pubmed: 18982271 ]
In the course of searching for PAF receptor antagonists, pregomisin (1) and Chamigrenal (2) were isolated from the fruits ofSchizandra chinensis Baill by the bioactivity-guided isolation.
METHODS AND RESULTS:
Both compounds showed PAF antagonistic activity and the IC(50) values were 4.8x10(-5) M and 1.2x10(-4) M, respectively. In addition, the(13)C NMR assignments of1 and2 using DEPT, HMQC, COLOC and HMBC were reported for the first time.
Chamigrenal Description
Source: The fruits of Schisandra chinensis.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Irigenin 3'-O-glucoside

Catalog No: CFN95578
CAS No: N/A
Price: $318/5mg
Oroselol

Catalog No: CFN95001
CAS No: 1891-25-4
Price: $358/5mg
Notoginsenoside L13

Catalog No: CFN95332
CAS No: 2485859-56-9
Price: $318/5mg
Naringin 6''-acetate

Catalog No: CFN95418
CAS No: 139934-60-4
Price: $318/5mg
Polygalin J

Catalog No: CFN95175
CAS No: N/A
Price: $318/5mg
Physalin G

Catalog No: CFN95104
CAS No: 76045-38-0
Price: $388/5mg
Isorhamnetin 3,5-O-diglucoside

Catalog No: CFN95488
CAS No: 2035413-03-5
Price: $318/5mg
Hosenkoside D

Catalog No: CFN95521
CAS No: 156823-94-8
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.5802 mL 22.9011 mL 45.8022 mL 91.6045 mL 114.5056 mL
5 mM 0.916 mL 4.5802 mL 9.1604 mL 18.3209 mL 22.9011 mL
10 mM 0.458 mL 2.2901 mL 4.5802 mL 9.1604 mL 11.4506 mL
50 mM 0.0916 mL 0.458 mL 0.916 mL 1.8321 mL 2.2901 mL
100 mM 0.0458 mL 0.229 mL 0.458 mL 0.916 mL 1.1451 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Cell Research:
Korean Journal of Food Science & Technology, 2014, 46(6):665-670.
The Antiproliferative Effects of Compounds Isolated from Schisandra chinensis.[Reference: WebLink]
We isolated twelve lignans and three terpenoids were isolated from the n-hexane fraction of Schisandra chinensis extract.
METHODS AND RESULTS:
Using spectroscopic data and comparison with available literature, the following compounds were identified: (1) wuweizisu C, (2) gomisin N, (3) deoxyschisandrin, (4) gomisin A, (5) schisandrin, (6) Chamigrenal, (7) schisanlactone D, (8) methylgomisin O, (9) angeloylgomisin O, (10) (-)-gomisin L2, (11) schisandronic acid, (12) (-)-gomisin L1, (13) (+)-gomisin K3, (14) gomisin J, and (15) tigloylgomisin H. Notably, this was the first finding that compound (8) was isolated from this plant. Each compound was evaluated for its in vitro cytotoxic activities toward HL-60 (human leukemia), HeLa (human cervical carcinoma), and MCF-7 (breast cancer) cell lines. Compounds (7), (8), and (9) exhibited strong cytotoxic effects on HL-60 (IC50 7.37, 6.60, and 8.00 μM, respectively), whereas compound (6) exhibited weak cytotoxicity towards MCF-7 (IC50 30.50 μM). In addition, compound (8) showed the strongest activity towards HeLa cells (IC50 1.46 μM).
Baicalin

Catalog No: CFN99111
CAS No: 21967-41-9
Price: $40/20mg
Beta-mangostin

Catalog No: CFN99723
CAS No: 20931-37-7
Price: $218/10mg
Procyanidin B3

Catalog No: CFN99559
CAS No: 23567-23-9
Price: $238/10mg
Kaempferol 7-O-rhamnoside

Catalog No: CFN96224
CAS No: 20196-89-8
Price: $338/10mg
gamma-Mangostin

Catalog No: CFN98396
CAS No: 31271-07-5
Price: $70/20mg
Isofraxidin

Catalog No: CFN90181
CAS No: 486-21-5
Price: $40/20mg
Vomifoliol

Catalog No: CFN98245
CAS No: 23526-45-6
Price: $ /
Grossamide

Catalog No: CFN97672
CAS No: 80510-06-1
Price: $318/5mg
3,4,5-Tricaffeoylquinic acid

Catalog No: CFN90238
CAS No: 86632-03-3
Price: $318/5mg
Zeaxanthin

Catalog No: CFN90234
CAS No: 144-68-3
Price: $ / mg
Tags: buy Chamigrenal | Chamigrenal supplier | purchase Chamigrenal | Chamigrenal cost | Chamigrenal manufacturer | order Chamigrenal | Chamigrenal distributor