Cochlearine | CAS:52418-07-2 | Manufacturer ChemFaces

Cochlearine

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Description:

Cochlearines A can significantly inhibit Cav3.1 T-type calcium channel (TTCC) and show noticeable selectivity against Cav1.2, Cav2.1, Cav2.2, and Kv11.1 (hERG) channels; and TTCC inhibitors hold great potential for the treatment of a variety of neurological disorders.

Targets:

Calcium Channel

In vitro:

Org. Lett., 2015, 17(12):3082-5.

Two New Classes of T-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear[Pubmed: 26024438]

T-type calcium channel (TTCC) inhibitors hold great potential for the treatment of a variety of neurological disorders.
METHODS AND RESULTS:
Cochlearoids A-E (1-5), five pairs of dimeric meroterpenoid enantiomers, and Cochlearines A (6) and B (7), two pairs of enantiomeric hybrid metabolites, were isolated and characterized from Ganoderma cochlear.
CONCLUSIONS:
Biological evaluation found that compounds (+)-1, (-)-3, and (±)-6 significantly inhibited Cav3.1 TTCC and showed noticeable selectivity against Cav1.2, Cav2.1, Cav2.2, and Kv11.1 (hERG) channels.

Cochlearine Description

Source:	The herbs of Cochlearia officinalis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Phytochemistry. 2006 Sep;67(18):2050-7.

Brassicaceae contain nortropane alkaloids.[Pubmed: 16884746]

The report of Cochlearine, the 3-hydroxybenzoate ester of tropine found in Cochlearia officinalis, Brassicaceae, initiated a screening for tropane alkaloids in Cochlearia species and for calystegines in further Brassicaceae.
METHODS AND RESULTS:
All ten Cochlearia species investigated contained Cochlearine, tropine, and pseudotropine. Calystegines, nortropane alkaloids deriving from pseudotropine, were also identified in all Cochlearia species and accumulated up to 0.5% dry mass in leaves. Brassicaceae species of all major lineages of the family were analysed for calystegines. Of the 43 species included in the study, 18 accumulated calystegines of various structures. This is the first screening of Brassicaceae for products of the tropane alkaloid pathway, which is known as characteristic for plants of Solanaceae family.
CONCLUSIONS:
The identification of calystegines in all branches of the Brassicaceae family including Aethionema, a species at the basis of the family, suggests tropane alkaloids as secondary compound typical for Brassicaceae.

Product Name	Cochlearine
Price:
CAS No.:	52418-07-2
Catalog No.:	CFN00213
Molecular Formula:	C₁₅H₁₉NO₃
Molecular Weight:	261.32 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Cochlearia officinalis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Neuroprotection Compound Library Alkaloids Compound Library Calcium Channel Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.8267 mL	19.1336 mL	38.2673 mL	76.5345 mL	95.6681 mL
5 mM	0.7653 mL	3.8267 mL	7.6535 mL	15.3069 mL	19.1336 mL
10 mM	0.3827 mL	1.9134 mL	3.8267 mL	7.6535 mL	9.5668 mL
50 mM	0.0765 mL	0.3827 mL	0.7653 mL	1.5307 mL	1.9134 mL
100 mM	0.0383 mL	0.1913 mL	0.3827 mL	0.7653 mL	0.9567 mL

CFN00212	Benzoyltropein	19145-60-9	245.32	C₁₅H₁₉NO₂
CFN00213	Cochlearine	52418-07-2	261.32	C₁₅H₁₉NO₃
CFN00216	Tropanyl 3-hydroxy-4-methoxycinnamate	86702-58-1	317.38	C₁₈H₂₃NO₄
CFN00219	Tropacocaine	537-26-8	245.32	C₁₅H₁₉NO₂
CFN00227	Atroscine	138-12-5	303.36	C₁₇H₂₁NO₄
CFN00228	Scopoline	487-27-4	155.20	C₈H₁₃NO₂
CFN00230	Tigloyltropeine	495-83-0	223.31	C₁₃H₂₁NO₂
CFN00231	Tigloidine	533-08-4	223.31	C₁₃H₂₁NO₂
CFN00232	Hyoscyamine	101-31-5	289.37	C₁₇H₂₃NO₃
CFN90713	Hyoscyamine sulfate hydrate	620-61-1	694.83	(C₁₇H₂₃NO₃)₂.H₂SO₄.H₂O