Conodurine | CAS:2665-57-8 | Manufacturer ChemFaces

Conodurine

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Description:

Conodurine shows leishmanicidal and antibacterial activities, it shows inhibition activity for acetyl (AChE) and butyrylcholinesterase (BuChE).

Targets:

AChR | BChR

In vivo:

Planta Med. 1994 Oct;60(5):455-9.

Isolation of bis-indole alkaloids with antileishmanial and antibacterial activities from Peschiera van heurkii (syn. Tabernaemontana van heurkii).[Pubmed: 7997477]

METHODS AND RESULTS:
Extracts from leaves and stem bark of Peschiera van heurkii (Muell. Arg.) L. Allorge (syn. Tabernaemontana van heurkii Muell. Arg., Apocynaceae) have been assayed for antileishmanial and antibacterial activities. The activities were concentrated in the alkaloid fractions which yielded 20 indole and bisindole alkaloids. The strongest leishmanicidal and antibacterial activities were observed with the dimeric alkaloids Conodurine (1), N-demethylConodurine (= gabunine) (2), and conoduramine (3).
CONCLUSIONS:
Weak toxicity towards macrophage host cells and strong activity against the intracellular amastigote form of Leishmania were observed for compounds 1 and 2. In vivo, 1 was less active than glucantime (= N-methylglucamine antimonate), the drug of reference, while 2 was devoid of activity at 100 mg/kg.

Conodurine Description

Source:	The leaf and stem-bark of Tabernaemontana corymbosa.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

An Acad Bras Cienc. 2008 Sep;80(3):419-26.

Two fast screening methods (GC-MS and TLC-ChEI assay) for rapid evaluation of potential anticholinesterasic indole alkaloids in complex mixtures.[Pubmed: 18797794]

METHODS AND RESULTS:
In this work two fast screening techniques were combined in order to easily identify novel cholinesterase inhibitors (ChEI). Gas chromatography-mass spectrometry (GC-MS) of the less polar alkaloidic fractions obtained from the acid-base extraction of the stalk of T. laeta revealed thirteen monoindole alkaloids, four of them confirmed by co-injection with previously isolated alkaloids. The others were tentatively identified by mass fragmentation analysis. By gas chromatography with flame ionization detection (GC-FID) and using isatin as internal standard, affinisine and voachalotine were determined as major compounds. These fractions and fourteen previously isolated alkaloids, obtained from root bark of T. laeta and T. hystrix were investigated for acetyl (AChE) and butyrylcholinesterase (BuChE) inhibitory activities by the modified Ellman's method in thin layer chromatography(TLC-ChEI).
CONCLUSIONS:
Results showed selective inhibition of the alkaloids heyneanine and Nb-methylvoachalotine for BuChE, and 19-epi-isovoacristine for AChE, whereas olivacine, affinisine, ibogamine, affinine, Conodurine and hystrixnine inhibited both enzymes. In addition to confirming that monoterpenoid indole alkaloids can be novel therapeutic agents for AD, this is the first report of the ChEI activity of olivacine, a pyridocarbazole alkaloid.

Structure Identification:

Phytochemistry. 2003 Jul;63(5):625-9.

Conodurine, conoduramine, and ervahanine derivatives from Tabernaemontana corymbosa.[Pubmed: 12809725]

METHODS AND RESULTS:
Four bisindole alkaloids, viz., 19'(S)-hydroxyConodurine, conodurinine, 19'(S)-hydroxyconoduramine, and 19'(S)-hydroxyervahanine A, in addition to Conodurine and ervahanine A, were obtained from the leaf and stem-bark extracts of Tabernaemontana corymbosa.
CONCLUSIONS:
The structures of the new alkaloids were determined using NMR and MS analysis.

Product Name	Conodurine
Price:
CAS No.:	2665-57-8
Catalog No.:	CFN89174
Molecular Formula:	C₄₃H₅₂N₄O₅
Molecular Weight:	704.91 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The leaf and stem-bark of Tabernaemontana corymbosa.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antibacterial Compound Library Anticholinesterase Compound Library Anti-leishmanial Compound Library Alkaloids Compound Library AChR Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.4186 mL	7.0931 mL	14.1862 mL	28.3724 mL	35.4655 mL
5 mM	0.2837 mL	1.4186 mL	2.8372 mL	5.6745 mL	7.0931 mL
10 mM	0.1419 mL	0.7093 mL	1.4186 mL	2.8372 mL	3.5466 mL
50 mM	0.0284 mL	0.1419 mL	0.2837 mL	0.5674 mL	0.7093 mL
100 mM	0.0142 mL	0.0709 mL	0.1419 mL	0.2837 mL	0.3547 mL

CFN97884	Vellosimine	6874-98-2	292.4	C₁₉H₂₀N₂O
CFN92612	(+)-Affinisine	2912-11-0	308.4	C₂₀H₂₄N₂O
CFN96211	Macusine B	6792-07-0	309.4	C₂₀H₂₅N₂O
CFN96170	Spegatrine	47326-53-4	325.4	C₂₀H₂₅N₂O₂
CFN96097	10-Hydroxy-16-epiaffinine	82513-70-0	340.4	C₂₀H₂₄N₂O₃
CFN96181	Pelirine	30435-26-8	354.5	C₂₁H₂₆N₂O₃
CFN96148	Taberpsychine	19452-84-7	308.4	C₂₀H₂₄N₂O
CFN97989	N-Methoxyanhydrovobasinediol	125180-42-9	338.5	C₂₁H₂₆N₂O₂
CFN96030	16-Epivoacarpine	114027-38-2	368.4	C₂₁H₂₄N₂O₄
CFN96018	Gelsempervine A	865187-17-3	382.5	C₂₂H₂₆N₂O₄