Coptisine sulfate | CAS:1198398-71-8 | Manufacturer ChemFaces

Coptisine sulfate

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Description:

Coptisine sulfate can competitively inhibit CYP2D6(*)1 and CYP2D6(*)10, its Ki values for CYP2D6(*)1 and CYP2D6(*)10 are very close, suggesting that genotype-dependent herb-drug inhibition is similar between the two variants.

Targets:

P450 (e.g. CYP17)

In vitro:

Acta Pharmacol Sin. 2014 May;35(5):685-96.

Inhibitory effects of phytochemicals on metabolic capabilities of CYP2D6(*)1 and CYP2D6(*)10 using cell-based models in vitro.[Pubmed: 24786236 ]

Herbal products have been widely used, and the safety of herb-drug interactions has aroused intensive concerns. This study aimed to investigate the effects of phytochemicals on the catalytic activities of human CYP2D6(*)1 and CYP2D6(*)10 in vitro.
METHODS AND RESULTS:
HepG2 cells were stably transfected with CYP2D6(*)1 and CYP2D6(*)10 expression vectors. The metabolic kinetics of the enzymes was studied using HPLC and fluorimetry. HepG2-CYP2D6(*)1 and HepG2-CYP2D6(*)10 cell lines were successfully constructed. Among the 63 phytochemicals screened, 6 compounds, including Coptisine sulfate, bilobalide, schizandrin B, luteolin, schizandrin A and puerarin, at 100 μmol/L inhibited CYP2D6(*)1- and CYP2D6(*)10-mediated O-demethylation of a coumarin compound AMMC by more than 50%. Furthermore, the inhibition by these compounds was dose-dependent. Eadie-Hofstee plots demonstrated that these compounds competitively inhibited CYP2D6(*)1 and CYP2D6(*)10. However, their Ki values for CYP2D6(*)1 and CYP2D6(*)10 were very close, suggesting that genotype-dependent herb-drug inhibition was similar between the two variants.
CONCLUSIONS:
Six phytochemicals inhibit CYP2D6(*)1 and CYP2D6(*)10-mediated catalytic activities in a dose-dependent manner in vitro. Thus herbal products containing these phytochemicals may inhibit the in vivo metabolism of co-administered drugs whose primary route of elimination is CYP2D6.

Coptisine sulfate Description

Source:	The roots of Chelidonium majus
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Coptisine sulfate
Price:	$108 / 20mg
CAS No.:	1198398-71-8
Catalog No.:	CFN90140
Molecular Formula:	C₁₉H₁₅NO₈S
Molecular Weight:	417.4 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The roots of Chelidonium majus
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Alkaloids Compound Library P450 (e.g. CYP17) Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3958 mL	11.9789 mL	23.9578 mL	47.9157 mL	59.8946 mL
5 mM	0.4792 mL	2.3958 mL	4.7916 mL	9.5831 mL	11.9789 mL
10 mM	0.2396 mL	1.1979 mL	2.3958 mL	4.7916 mL	5.9895 mL
50 mM	0.0479 mL	0.2396 mL	0.4792 mL	0.9583 mL	1.1979 mL
100 mM	0.024 mL	0.1198 mL	0.2396 mL	0.4792 mL	0.5989 mL

CFN90140	Coptisine sulfate	1198398-71-8	417.4	C₁₉H₁₅NO₈S
CFN98049	Berberine	2086-83-1	336.4	C₂₀H₁₈NO₄
CFN99562	Berberine hydrochloride	633-65-8	371.81	C₂₀H₁₈NO₄Cl
CFN90432	Berberine hydrogen sulphate	633-66-9	433.43	C₂₀H₁₉NO₈S
CFN90509	Berberrubine	15401-69-1	322.33	C₁₉H₁₆NO₄+
CFN98564	Epiberberine	6873-09-2	336.36	C₂₀H₁₈NO₄
CFN99563	Coptisine	3486-66-6	320.32	C₁₉H₁₄NO₄
CFN99564	Coptisine chloride	6020-18-4	355.77	C₁₉H₁₄NO₄Cl
CFN93056	13-Methylberberine	54260-72-9	385.84	C₂₁H₂₀ClNO₄