Cudraflavone B | CAS:19275-49-1 | Manufacturer ChemFaces

Cudraflavone B

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Description:

Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mouse melanoma cells, and hepatoprotective activity. It may be a lead for the development of a potential candidate for human oral squamous cell carcinoma cells.

Targets:

MAO | COX | ROS | HO-1 | Nrf2 | PI3K | Akt | IkB | IKK

In vitro:

J Nat Prod. 2013 Sep 27;76(9):1586-91.

Prenylated and geranylated flavonoids increase production of reactive oxygen species in mouse macrophages but inhibit the inflammatory response.[Pubmed: 23947936 ]

In this study, four prenylated and geranylated flavonoids, Cudraflavone B (1), pomiferin (2), osajin (3), and diplacone (4), were tested for their antioxidant and anti-inflammatory effects and to identify any potential relationships between chemical structure and antioxidant or anti-inflammatory properties.
METHODS AND RESULTS:
The selected flavonoids were examined in cell-free models to prove their ability to scavenge superoxide radicals, hydrogen peroxide, and hypochlorous acid. Further, the ability of the flavonoids to influence the formation of reactive oxygen species in the murine macrophage cell line J774.A1 was tested in the presence and absence of lipopolysaccharide (LPS). The ability of flavonoids to inhibit LPS-induced IκB-α degradation and COX-2 expression was used as a model for the inflammatory response.
CONCLUSIONS:
The present results indicated that the antioxidant activity was dependent on the chemical structure, where the catechol moiety is especially crucial for this effect. The most potent antioxidant activities in cell-free models were observed for diplacone (4), whereas Cudraflavone B (1) and osajin (3) showed a pro-oxidant effect in J774.A1 cells. All flavonoids tested were able to inhibit IκB-α degradation, but only diplacone (4) also down-regulated COX-2 expression.

Cudraflavone B Description

Source:	The herbs of Cudrania tricuspidata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Cell Research:

Molecules. 2014 Jul 24;19(8):10818-31.

Cudarflavone B provides neuroprotection against glutamate-induced mouse hippocampal HT22 cell damage through the Nrf2 and PI3K/Akt signaling pathways.[Pubmed: 25061726 ]

Oxidative cell damage contributes to neuronal degeneration in many central nervous system (CNS) diseases such as Alzheimer's disease, Parkinson's disease, and ischemia. Nrf2 signaling-mediated heme oxygenase (HO)-1 expression acts against oxidants that are thought to play a key role in the pathogenesis of neuronal diseases. Cudraflavone B is a prenylated flavone isolated from C. tricuspidata which has shown anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mouse melanoma cells, and hepatoprotective activity.
METHODS AND RESULTS:
In this study, Cudraflavone B showed neuroprotective effects and reactive oxygen species (ROS) inhibition against glutamate-induced neurotoxicity by inducing the expression of HO-1 in mouse hippocampal HT22 cells. Furthermore, Cudraflavone B caused the nuclear accumulation of nuclear factor-E2-related factor 2 (Nrf2) and increased the promoter activity of antioxidant response elements (ARE) in mouse hippocampal HT22 cells. In addition, we found that the Nrf2-midiated HO-1 expression by Cudraflavone B is involved in the cell protective response and ROS reductions, and Cudraflavone B-induced expression of HO-1 was mediated through the phosphatidylinositol 3-kinase (PI3K)/Akt pathway in HT22 cells.
CONCLUSIONS:
Our results demonstrated the potential application of naturally occurring Cudraflavone B as a therapeutic agent from neurodegenerative disease.

Product Name	Cudraflavone B
Price:
CAS No.:	19275-49-1
Catalog No.:	CFN91905
Molecular Formula:	C₂₅H₂₄O₆
Molecular Weight:	420.45 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The herbs of Cudrania tricuspidata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Flavonoids Compound Library ROS Inhibitor Library PI3K Inhibitor Library Nrf2 Inhibitor Library MAO Inhibitor Library IKK Inhibitor Library IkB Inhibitor Library HO-1 Inhibitor Library COX Inhibitor Library Akt Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3784 mL	11.892 mL	23.784 mL	47.5681 mL	59.4601 mL
5 mM	0.4757 mL	2.3784 mL	4.7568 mL	9.5136 mL	11.892 mL
10 mM	0.2378 mL	1.1892 mL	2.3784 mL	4.7568 mL	5.946 mL
50 mM	0.0476 mL	0.2378 mL	0.4757 mL	0.9514 mL	1.1892 mL
100 mM	0.0238 mL	0.1189 mL	0.2378 mL	0.4757 mL	0.5946 mL

CFN96520	Topazolin	109605-79-0	368.39	C₂₁H₂₀O₆
CFN91905	Cudraflavone B	19275-49-1	420.45	C₂₅H₂₄O₆
CFN98528	Noricaritin	5240-95-9	372.37	C₂₀H₂₀O₇
CFN90767	Sophoflavescenol	216450-65-6	368.4	C₂₁H₂₀O₆
CFN93597	Isoanhydroicaritin	28610-30-2	368.4	C₂₁H₂₀O₆
CFN98527	Icaritin	118525-40-9	368.38	C₂₁H₂₀O₆
CFN98526	Anhydroicaritin	38226-86-7	368.38	C₂₁H₂₀O₆
CFN91888	Citrusinol	112516-43-5	352.34	C₂₀H₁₆O₆
CFN92774	Broussoflavonol B	99217-70-6	452.5	C₂₆H₂₈O₇
CFN96053	8-Lavandulylkaempferol	883859-83-4	422.5	C₂₅H₂₆O₆