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    Cyclo(L-Leu-trans-4-hydroxy-L-Pro)
    Cyclo(L-Leu-trans-4-hydroxy-L-Pro)
    Information
    CAS No. 115006-86-5 Price $332 / 10mg
    Catalog No.CFN96088Purity>=98%
    Molecular Weight226.3Type of CompoundAlkaloids
    FormulaC11H18N2O3Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Cyclo(L-Leu-trans-4-hydroxy-L-Pro) is a natural product from Phellinus igniarius.
    Cyclo(L-Leu-trans-4-hydroxy-L-Pro) Description
    Source: From Phellinus igniarius
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

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    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

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    Phytomedicine. 2018 Feb 1;40:37-47.
    doi:10.1016/j.phymed.2017.12.030

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.4189 mL 22.0946 mL 44.1891 mL 88.3783 mL 110.4728 mL
    5 mM 0.8838 mL 4.4189 mL 8.8378 mL 17.6757 mL 22.0946 mL
    10 mM 0.4419 mL 2.2095 mL 4.4189 mL 8.8378 mL 11.0473 mL
    50 mM 0.0884 mL 0.4419 mL 0.8838 mL 1.7676 mL 2.2095 mL
    100 mM 0.0442 mL 0.2209 mL 0.4419 mL 0.8838 mL 1.1047 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Chemical Research & Application, 2014 (9) :1478-1482.
    Cyclic dipeptides metabolites from the symbiotic fungus paraconiothyrium brasiliense[Reference: WebLink]
    Nine cyclic dipeptides secondary metabolites were isolated from the symbiotic fungus paraconiothyrium brasiliense,by normal phase silica gel,Sephadex LH-20 chromatography and reverse phase HPLC.
    METHODS AND RESULTS:
    Their structures were elucidated as cyclo-( LLeu-L-Tyr)(1),cyclo-(L-Trp-L-Pro)(2),cyclo-( L-Pro-L-Phe)(3),cyclo-( L-Pro-L-Tyr)(4),cyclo-( L-Pro-L-Leu)(5),Cyclo(L-Leu-trans-4-hydroxy-L-Pro)(6),cyclo-(L-Ile-L-Pro)(7),cyclo-(L-Val-L-Pro)(8),cyclo-(L-Leu-L-Ile)(9)by NMR,MS and physicochemical properties.
    CONCLUSIONS:
    All the compounds were isolated from the symbiotic fungus paraconiothyrium brasiliense for the first time.