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Cyclo(Tyr-Leu)
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Cyclo(Tyr-Leu)
Price: $238 / 10mg
CAS No.: 82863-65-8
Catalog No.: CFN90287
Molecular Formula: C15H20N2O3
Molecular Weight: 276.33 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The roots of Panax notoginseng.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
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Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / $99.2 / In-stock
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Cyclo(Tyr-Leu) shows cytotoxicity, antifungal,and anticoagulant activities.
Targets: Antifection
In vitro:
Natural Product Research 2013, 27(23):2168-217
Isolation and antifungal properties of cyclo(D-Tyr-L-Leu) diketopiperazine isolated from Bacillus sp. associated with rhabditid entomopathogenic nematode.[Reference: WebLink]
Bacillus sp. associated with an entomopathogenic nematode is shown to produce diketopiperazine (DKP) that showed stronger antifungal activity against Colletotrichum gloeosporioides [minimum inhibitory concentration (MIC): 8 μg mL(- 1)] than commercial fungicide oligochitosan (MIC: 125 μg mL(- 1)).
METHODS AND RESULTS:
DKP identified as cyclo(D-Tyr-L-Leu) was isolated for the first time from a natural source with a d-tyrosine residue. This report also demonstrates for the first time an antifungal property exploration of Cyclo(Tyr-Leu) class of dipeptides.
CONCLUSIONS:
The structural elucidation was carried out using 1D, 2D NMR methods and HPLC.
Chinese Journal of Antibiotics,2006, 31(1):36-38,62.
The antitumor active component from marine derived actinomycete S1001[Reference: WebLink]
To explore the antitumor active component in fermentation of a marine derived actinomycete S1001,8 compounds were isolated and purified by using solvent extraction,silica gel column and preparative HPLC.
METHODS AND RESULTS:
The separation procedure was traced by a bioassay using tsFT210 cell lines.By means of physico-chemical properties and spectral analyses,the structures of compounds were determined as: 4′,5,7-trihydroxyisoflavone(),4-(2,4-dihydroxybenzamido) benzoic acid (2),cyclo-(Gly-Ala)(3),cyclo-(Gly-Pro) (4),Cyclo(Tyr-Leu)(5),cyclo-(Val-Leu)(6),cyclo-(Val-Ile)(7),cyclo-(Phe-Gly)(8),respectively.The antitumor activities of these compounds were assayed by the SRB method against K562 cell line.
CONCLUSIONS:
Compounds 4, 5 and 7 showed cytotoxicity at the concentration of 10 μmol/L.
Chinese Traditional Patent Medicine, 2015,37 (1) : 34-9.
Anticoagulant activity of cyclic dipeptides from Sparganii Rhizome[Reference: WebLink]
To study the in vitro anticoagulant activity of cyclodipeptide Cyclo(Tyr-Leu),cyclo-( PhePhe) and cyclo-( Phe-Tyr)) isolated from Sparganium stoloniferum Buch.-Ham.
METHODS AND RESULTS:
The special kits were used to measure anticoagulant activity with platelet poor plasma collected from abdominal aorta of male SD rats,including prothrombin time( PT),activated partial thromboplastin time( APTT) and thrombin time( TT).PT,APTT,TT were prolonged by the addition of cyclo-( Tyr-Leu),cyclo-( Phe-Phe) and cyclo-( Phe-Tyr). The former two presented no dose-effect relationship but the latter did.
CONCLUSIONS:
Of three cyclodipeptides from S. stoloniferum,all the three show anticoagulant activities with cyclo-( Phe-Tyr) being by far the most effective.
Cyclo(Tyr-Leu) Description
Source: The roots of Panax notoginseng.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.6189 mL 18.0943 mL 36.1886 mL 72.3772 mL 90.4715 mL
5 mM 0.7238 mL 3.6189 mL 7.2377 mL 14.4754 mL 18.0943 mL
10 mM 0.3619 mL 1.8094 mL 3.6189 mL 7.2377 mL 9.0472 mL
50 mM 0.0724 mL 0.3619 mL 0.7238 mL 1.4475 mL 1.8094 mL
100 mM 0.0362 mL 0.1809 mL 0.3619 mL 0.7238 mL 0.9047 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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