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Cyclo(Tyr-Pro)
Cyclo(Tyr-Pro)
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Cyclo(Tyr-Pro)
Price: $238 / 10mg
CAS No.: 5654-84-2
Catalog No.: CFN90276
Molecular Formula: C14H16N2O3
Molecular Weight: 260.29 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: From Penicillium oxalicum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
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Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $99.2 / In-stock
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Cyclo(Tyr-Pro) shows antibacterial activity towards several marine bacterial species, it also shows weak antagonistic activity against VEGFR2 -CD. Cyclo(Tyr-Pro) and cyclo(Pro-Val) are toxic to both suspension cells and seedlings of Pinus thunbergii, which may offer some clues to research the mechanism of pine wilt disease caused by pine wood nematode.
Targets: VEGFR | Antifection
In vitro:
Die Pharmazie - An International Journal of Pharmaceutical Sciences,2011,66(6):421-3.
Antimicrobial activity of liposome encapsulated cyclo(L-tyrosyl-L-prolyl)[Reference: WebLink]
Various studies have shown the potentially beneficial biological activities of cyclic dipeptides and in particular, cyclo(L-tyrosyl-L-prolyl) (Cyclo(Tyr-Pro)) has shown fair antibacterial activity in vitro. This study aimed to determine if liposome encapsulation would have any significant effects on the antibacterial activity of this compound.
METHODS AND RESULTS:
The thin-film hydration method with extrusion was used to produce small unilamellar vesicles containing Cyclo(Tyr-Pro) that were shown to have an average encapsulation of 9.4% with a mean particle size of 160.4 nm. Minimum inhibitory concentrations tested against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Bacillus subtillis were shown to be lower in liposome encapsulated Cyclo(Tyr-Pro) than for the free form, while no antimicrobial activity was noted for either encapsulated nor non-encapsulated drug against the fungus Candida albicans or two methicillin-resistant strains of Staphylococcus aureus (MRSA). A positive control of liposome encapsulated amoxicillin was shown to be extremely active against both MRSA strains.
CONCLUSIONS:
The results confirm that liposome encapsulation has the potential to enhance activity as well as to overcome bacterial resistance towards current antibacterial agents.
J Nematol. 2007 Sep;39(3):243-7.
Two Cyclic Dipeptides from Pseudomonas fluorescens GcM5-1A Carried by the Pine Wood Nematode and Their Toxicities to Japanese Black Pine Suspension Cells and Seedlings in vitro.[Pubmed: 19259494 ]

METHODS AND RESULTS:
Pseudomonas fluorescens GcM5-1A, isolated from the pine wood nematode (PWN), Bursaphelenchus xylophilus, was cultured in Luria Broth medium (LB). The clarified culture was extracted with ethyl acetate, and two dipeptides were purified from the extract. The chemical structures of 1 and 2 were identified as cyclo(-Pro-Val-)and Cyclo(Tyr-Pro), respectively, by MS, (1)H NMR, (13)C NMR,(1)H-(1)H COSY, 1H -(13)C COSY spectra.
CONCLUSIONS:
Bioassay results showed that the two compounds were toxic to both suspension cells and seedlings of Pinus thunbergii, which may offer some clues to research the mechanism of pine wilt disease caused by PWN.
Natural Product Research & Development, 2009,21(3): 420-3.
Antibacterial Metabolites from Marine Bacterium Pseudomonas sp.[Reference: WebLink]

METHODS AND RESULTS:
Nine cyclic dipeptides,Cyclo(Tyr-Pro)(1),cyclo-(Tyr-Ile)(2),cyclo-(Phe-Pro)(3),cyclo-(Val-Pro)(4),cyclo-(Ile-Pro)(5),cyclo-(Leu-Pro)(6),cyclo-(Ala-Pro)(7),cyclo-(Ala-Val)(8),cyclo-(Ala-Leu)(9) together with two benzene compounds p-hydroxy-benzaldehyde(10),bis(2-ethylhexyl) phthalate(11) were isolated from the culture broth of marine bacterium Pseudomonas sp.,and identified on the basis of spectroscopic evidences and by comparison of the data reported compounds 1-4 showed antibacterial activity towards several marine bacterial species.
Cyclo(Tyr-Pro) Description
Source: From Penicillium oxalicum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

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doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
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IF=12.804(2019)

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.8419 mL 19.2093 mL 38.4187 mL 76.8374 mL 96.0467 mL
5 mM 0.7684 mL 3.8419 mL 7.6837 mL 15.3675 mL 19.2093 mL
10 mM 0.3842 mL 1.9209 mL 3.8419 mL 7.6837 mL 9.6047 mL
50 mM 0.0768 mL 0.3842 mL 0.7684 mL 1.5367 mL 1.9209 mL
100 mM 0.0384 mL 0.1921 mL 0.3842 mL 0.7684 mL 0.9605 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Chinese Journal of Antibiotics,2014,6:408-12,421.
Discovery on antagonists of VEGFR2-CD produced by Streptomyces strain I06A-02832.[Reference: WebLink]
To discover antagonists of VEGFR2-CD from the fermentation broth produced by streptomyces strain I06A-02832.
METHODS AND RESULTS:
Under the guidance of ELISA assay against VEGFR2-CD, Compounds 2832B and 2832C were isolated and purified by combination of different column chromatographies and HPLC. The structures of compounds 2832B and C were identified by combination of analysis of UV, IR, MS and 1D-NMR, 2D-NMR. Compounds 2832B and 2832C were purified and structurally identified as cyclic dipeptides, and were the same with Cyclo(Tyr-Pro) and cyclo-(Phe-Gly) respectively. Compounds 2832B and 2832C showed weak antagonistic activity against VEGFR2-CD by ELISA assay.
CONCLUSIONS:
They are firstly reported compounds 2832B and 2832C had antagonistic activity against VEGFR2-CD.
Structure Identification:
Journal of Crystallographic and Spectroscopic Research December 1992,22(6):643-649.
Cyclodipeptides: Structure and conformation of cyclo(tyrosyl-prolyl)[Reference: WebLink]

METHODS AND RESULTS:
The structure and conformation of the cyclodipeptide, cyclo(Tyrosyl-Prolyl), Cyclo(Tyr-Pro) have been investigated with X-ray crystallographic and spectroscopic methods. Two conformations of Cyclo(Tyr-Pro) crystallized in the space groupP21212 with cell dimensionsa=11.890(3),b=12.057(1),c=18.528(4). Both these conformations are uncommon for cyclodipeptides containing a proline residue. The tyrosyl side chains of these conformers are folded towards the diketopiperazine (DKP) ring. The DKP ring adopts a flattened chair conformation in contrast to the typical boat conformation generally observed for DKP rings. The conformation of the pyrrolidine ring can be described as a pseudo C2 symmetrical twist. One intermolecular hydrogen bond was observed for each of the two conformations of Cyclo(Tyr-Pro). The hydrogen of the hydroxyl group of the tyrosyl residue is hydrogen bonded to the oxygen of the carbonyl group of the diketopiperazine ring, i.e., the carbonyl group originating from the tyrosyl residue.
CONCLUSIONS:
NMR spectroscopic studies indicated a different conformation for Cyclo(Tyr-Pro) in solution similar to the generally observed conformation of cyclodipeptides, i.e., extended aromatic side chain and boat conformation for the DKP ring.
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