|Source:||The herbs of Liriodendron tulipifera|
|Biological Activity or Inhibitors:||1. (+)-Syringaresinol shows inhibitory activity of Helicobacter pylori motility with the IC50 value is 50 microg/ml.
2. (-)-Syringaresinol has been reported to potently inhibit the proliferation of human promyelocytic HL-60 cells through G 1 arrest and induction of apoptosis, suggests that it may be a potential chemotherapeutic agent for the treatment of cancer.
3. Syringaresinol induces vasorelaxation by enhancing NO production in endothelial cells via two distinct mechanisms, phosphatidylinositol 3-kinase/Akt- and (PLC)/Ca2+/CaMKKβ -dependent eNOS phosphorylation and Ca(2+)-dependent eNOS dimerization.
4. Syringaresinol can protect against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1α in a FOXO3-dependent mechanism.
|Solvent:||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||2.3901 mL||11.9503 mL||23.9006 mL||47.8011 mL||59.7514 mL|
|5 mM||0.478 mL||2.3901 mL||4.7801 mL||9.5602 mL||11.9503 mL|
|10 mM||0.239 mL||1.195 mL||2.3901 mL||4.7801 mL||5.9751 mL|
|50 mM||0.0478 mL||0.239 mL||0.478 mL||0.956 mL||1.195 mL|
|100 mM||0.0239 mL||0.1195 mL||0.239 mL||0.478 mL||0.5975 mL|
Chemische Berichte Volume 98, Issue 2, pages 538–539, Februar 1965
|Isolierung von DL-Syringaresinol aus Buchenholz[Reference: WebLink]|
|Bei der Perkolation von Buchenholz mit 2-proz. Essigsäure in der Hitze geht das Buchenlignin teilweise in Lösung. Unter den im Extrakt vorkommenden niedermolekularen Phenolen findet sich DL-Syringaresinol.|
Biol Pharm Bull. 2006 Jan;29(1):172-3.
|Inhibition of Helicobacter pylori motility by (+)-Syringaresinol from unripe Japanese aprico[Pubmed: 16394533]|
|A methanol extract from unripe Japanese apricot showed inhibitory activity of Helicobacter pylori motility. Inhibitory compound 1 was isolated and identified as (+)-syringaresinol (1) by spectoroscopic means. (+)-Syringaresinol (1) inhibited >90% of the H. pylori motility at a concentration of 500 microg/ml and the IC50 value was 50 microg/ml.|
Int Immunopharmacol. 2008 Jul;8(7):967-73.
|(-)-Syringaresinol inhibits proliferation of human promyelocytic HL-60 leukemia cells via G1 arrest and apoptosis.[Pubmed: 18486907]|
|The induction of apoptosis after treatment with (-)-syringaresinol for 24 h was demonstrated by morphological changes, DNA fragmentation, altered ratio of Bax/Bcl-2, cleavage of poly(ADP-ribose) polymerase and flow cytometry analysis. (-)-Syringaresinol also induced cytochrome c release and activation of caspase-3 and caspase-9. To our knowledge, this is the first time that (-)-syringaresinol has been reported to potently inhibit the proliferation of human promyelocytic HL-60 cells through G(1) arrest and induction of apoptosis. These findings suggest that (-)-syringaresinol may be a potential chemotherapeutic agent for the treatment of cancer.|