Demethylmurrayanine | CAS:123497-84-7 | Manufacturer ChemFaces

Demethylmurrayanine

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Description:

O-Demethylmurrayanine and clausine D exhibit strong cytotoxicity against MCF-7 and SMMC-7721 with IC50 values in the range 2.63-7.59 ug/ml.

In vitro:

Phytochem. Lett.,2014, 9(3):92-95.

Two new cytotoxic constituents from the Clausena lansium (Lour.) Skeels[Reference: WebLink]

METHODS AND RESULTS:
Two new compounds 6-methoxy-9H-carbazole-3-carboxylic acid ( 1 ) and 9-[3-methyl-4-(4-methyl-5-oxo-tetrapydro-furan-2-yl)-but-2-enyloxy]-furo[3,2-g]chromen-7-one ( 5 ) along with four known compounds clausine D ( 2 ), claulansines J ( 3 ), O-Demethylmurrayanine ( 4 ) and pabularinone ( 6 ) were isolated from the Clausena lansium . The chemical structures of the new compound were elucidated by 1D and 2D NMR as well as HR-ESIMS spectral analysis. All the compounds isolated were evaluated for cytotoxic effects against human breast cancer (MCF-7), non-small lung carcinoma (H1299) and liver cancer (SMMC-7721).
CONCLUSIONS:
Compounds 2 and 4 exhibited strong cytotoxicity against MCF-7 and SMMC-7721 with IC 50 values in the range 2.63–7.5902μg/ml, and Compounds 1 and 5 showed moderate cytotoxicity against MCF-7, H1299 and SMMC-7721 tumor cell lines.

Demethylmurrayanine Description

Source:	The herbs of Clausena dunniana
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Demethylmurrayanine
Price:
CAS No.:	123497-84-7
Catalog No.:	CFN97840
Molecular Formula:	C₁₃H₉NO₂
Molecular Weight:	211.22 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Yellow powder
Source:	The herbs of Clausena dunniana
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Cytotoxic Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.7344 mL	23.672 mL	47.344 mL	94.688 mL	118.36 mL
5 mM	0.9469 mL	4.7344 mL	9.4688 mL	18.9376 mL	23.672 mL
10 mM	0.4734 mL	2.3672 mL	4.7344 mL	9.4688 mL	11.836 mL
50 mM	0.0947 mL	0.4734 mL	0.9469 mL	1.8938 mL	2.3672 mL
100 mM	0.0473 mL	0.2367 mL	0.4734 mL	0.9469 mL	1.1836 mL

CFN89173	Glycoborinine	233279-39-5	279.33	C₁₈H₁₇NO₂
CFN96594	Carbazole	86-74-8	167.21	C₁₂H₉N
CFN97777	3-Methyl-9H-carbazol-2-ol	24224-30-4	197.23	C₁₃H₁₁NO
CFN98862	Glycozolinine	5257-08-9	197.2	C₁₃H₁₁NO
CFN97821	Clausine D	142846-95-5	279.34	C₁₈H₁₇NO₂
CFN97840	Demethylmurrayanine	123497-84-7	211.22	C₁₃H₉NO₂
CFN91484	Murrayanine	723-97-7	225.2	C₁₄H₁₁NO₂
CFN91823	Clausine E	182261-83-2	241.2	C₁₄H₁₁NO₃
CFN97428	Clausine Z	866111-14-0	227.2	C₁₃H₉NO₃
CFN97800	Clausine I	182261-94-5	241.24	C₁₄H₁₁NO₃