ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
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More articles cited ChemFaces products.
Analytical sci. & Tech2016Acta Physiologiae Plantarum.2014 10.Br J Pharmacol.2016 Jan;173(2):396-410.Am J Chin Med.2016;44(8)Sci Rep. 2017 Jan 9;
Cytotechnology. 2017 Apr 3.BangaloreOct/Dec 2017;The Japan Society for Analy. Chem.2017 Nov. 8;Int J Mol Sci.2015 Aug 7;16(8):18396-411.?Acta Pharmaceutica Sinica B2015 Apr.7.
Evid Based Complement Alternat Med. 2016 Jun 13.Evid Based Complement Alternat Med. 2018;Inflammation.2015 Feb;38(1):445-55. Scientific Research.2015 Jan 6; 14-23
Our products had been exported to the following research institutions and universities, And still growing.
Universidade Federal de Goias (U... (Brazil)Amity University (India)Julius Kühn-Institut (Germany)Lund University (Sweden)
Agricultural Research Organizati... (Israel)Nicolaus Copernicus Uniwersity (Poland)St. Jude Children Research Hospi... (USA)University of Illinois at Chicago (USA)
University of Canterbury (New Zealand)University of Wuerzburg (Germany)Macau University of Science and ... (China)
||Diosbulbin D shows direct toxic effect on hepatocytes, the mechanism could be associated with oxidative stress.|
|Chinese Journal of Natural Medicines, 2011, 9(4):280-5. |
|Toxicity of a Diterpene Lactone Isolated from Dioscorea bulbifera on Hepatocytes[Reference: WebLink]|
|To test the toxic effects of a diterpene lactone, diosbulbin-D, isolated from Dioscorea bulbifera L. on hepatocytes.
METHODS AND RESULTS:
Using the MTT assay to test the effect of Diosbulbin D on hepatocytes.Selected intracellular enzymes release levels by diosbulbin-D were determined to further validate the toxic effect on hepatocytes.Furthermore,the level of intracellular glutathione and the induction of reactive oxygen species(ROS) by diosbulbin-D were measured by fluorometric and flow cytometry methods. Diosbulbin-D showed toxic effect on hepatocytes and a significant increase in intracellular release levels of LDH and the liver enzymes,alanine aminotransferase and aspartate aminotransferase confirmed diosbulbin-D's toxic effect.ROS increase was related to the decrease in level of GSH.Cell pretreated NAC almost completely blocked the ROS fluorescence and recovered the cell growth inhibition induced by diosbulbin-D.
Diosbulbin-D shows direct toxic effect on hepatocytes.The mechanism could be associated with oxidative stress.
Diosbulbin D Description
||The roots of Dioscorea bulbifera
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Diosbulbin d and 8-epidiosbulbin e acetate, norclerodane diterpenoids from dioscorea bulbifera tubers.[Reference: WebLink]|
METHODS AND RESULTS:
From tubers of Dioscorea buibifera L. var sativa a new 18-norclerodane diterpenoid, 8-epidiosbulbin E acetate, has been isolated, besides the previously known norditerpenoid, Diosbulbin D, and its structure established by spectroscopic means.