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    Dipsacoside B
    Information
    CAS No. 33289-85-9 Price $100 / 20mg
    Catalog No.CFN99150Purity>=98%
    Molecular Weight1074.56Type of CompoundTriterpenoids
    FormulaC53H86O22Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $68.5 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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  • Biological Activity
    Description: Dipsacoside B shows strong antimicrobial activity (MIC values 1.80-2.50 μg/mL).
    Targets: Antifection
    In vitro:
    Planta Med. 2009 Feb;75(2):163-7.
    Biologically active triterpenoids from Cephalaria ambrosioides.[Pubmed: 19152225 ]

    METHODS AND RESULTS:
    The roots of Cephalaria ambrosioides yielded a new triterpene, 6alpha-hydroxyhederagenic acid ( 1), in addition to the known triterpene hederagenic acid ( 2) and four corresponding saponins, leontoside A (or akeboside Stb) ( 3), kalopanax saponin A (or alpha-hederin) ( 4), saponin PG (or sapindoside B) ( 5), and Dipsacoside B ( 6). Their structures have been elucidated on the basis of their spectral data (MS, 1 D and 2 D NMR) and by some chemical transformations. The extract and all isolated compounds were evaluated for their antimicrobial, molluscicidal and IN VITRO cytotoxic activities.
    CONCLUSIONS:
    All compounds showed strong antimicrobial activity (MIC values 1.80 - 2.50 microg/mL), with 5 and 6 exhibiting activities comparable to those of standard antibiotics. Moreover, compounds 3 - 5 were active against all assayed cancer cell lines, whereas compounds 3 and 4 exhibited higher activities against Biomphalaria Glabrata snails, with minimum inhibitory concentrations of 5.4 and 6.2 microg/mL, respectively.
    Dipsacoside B Description
    Source: The flowerbuds of Lonicera confusa DC.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    IF=36.216(2019)

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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.9306 mL 4.6531 mL 9.3061 mL 18.6123 mL 23.2653 mL
    5 mM 0.1861 mL 0.9306 mL 1.8612 mL 3.7225 mL 4.6531 mL
    10 mM 0.0931 mL 0.4653 mL 0.9306 mL 1.8612 mL 2.3265 mL
    50 mM 0.0186 mL 0.0931 mL 0.1861 mL 0.3722 mL 0.4653 mL
    100 mM 0.0093 mL 0.0465 mL 0.0931 mL 0.1861 mL 0.2327 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Zhongguo Zhong Yao Za Zhi. 2013 Mar;38(5):762-7.
    Research on quality standards of zhuang medicine Lonicerae dasystylae flos[Pubmed: 23724691]
    To establish quality standard of Zhuang medicine Lonicera dasystyla, and provide scientific basis for the quality control of L. dasystyla.
    METHODS AND RESULTS:
    Characteristics of materia medica, microscopic features, TLC indentification, inspection, extractum and determination of chlorogenic acid, macranthoidin B, Dipsacoside B were carried out through the experience, microscopic, physical and chemical methods, respectively. The standard of quality control was formulated thereafter. The characteristics of materia medica, microscopic features, TLC indentification were specified, the average contents of water, total ash, acid-insoluble ash, alcohol-soluble extracts, chlorogenic acid were 11.6%, 6.6%, 0.2% , 24.4%, 1.16%, respectively, the total amount of macranthoidin B and Dipsacoside B was 3.13%. Quality standard of L. dasystyla was proposed according to experimental results.
    CONCLUSIONS:
    The quality of L. dasystyla can be controlled effectively with the quality standard.