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    Dregeoside Aa1
    Dregeoside Aa1
    Information
    CAS No. 20230-41-5 Price
    Catalog No.CFN97790Purity>=98%
    Molecular Weight939.15Type of CompoundSteroids
    FormulaC49H78O17Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Dregeoside Aa1 is a natural product from Dregea volubilis.
    Dregeoside Aa1 Description
    Source: The herbs of Dregea volubilis
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi:10.1016/j.phymed.2017.12.030

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.0648 mL 5.324 mL 10.6479 mL 21.2959 mL 26.6198 mL
    5 mM 0.213 mL 1.0648 mL 2.1296 mL 4.2592 mL 5.324 mL
    10 mM 0.1065 mL 0.5324 mL 1.0648 mL 2.1296 mL 2.662 mL
    50 mM 0.0213 mL 0.1065 mL 0.213 mL 0.4259 mL 0.5324 mL
    100 mM 0.0106 mL 0.0532 mL 0.1065 mL 0.213 mL 0.2662 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Chemical & Pharmaceutical Bulletin, 1983 , 31 (11) :3971-83.
    Studies on the constituents of asclepiadaceae plants. LVI. Isolation of new antitumor-active glycosides from Dregea volubilis (L.) BENTH.[Reference: WebLink]
    Seven new glycosides were isolated from the stem of Dregea volubilis (L.) BENTH.
    METHODS AND RESULTS:
    The structures of dregeoside Ap1 (1), dregeoside Ao1 (2), Dregeoside Aa1 (3), dregeoside A11 (4), dregeoside C11 (5), dregeoside Ka1 (6), and dregeoside Ka1 (7) were deduced on the basis of chemical and spectral evidence as drevogenin A 3-O-3-O-methyl-6-deoxy-β-D-allopyranosyl-(1→4)-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside, drevogenin A 3-O-β-D-glucopyranosyl-(1→4)-3-O-methyl-6-deoxy-β-D-allopyranosyl-(1→4)-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside, drevogenin A 3-O-3-O-methyl-6-deoxy-β-D-allopyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside, drevogenin A 3-O-β-D-glucopyranosyl-(1→4)-3-O-methyl-6-deoxy-β-D-allopyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside, drevogenin C 3-O-β-D-glucopyranosyl-(1→4)-3-O-methyl-6-deoxy-β-D-allopyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside, drebyssogenin K2 3-O-3-O-methyl-6-deoxy-β-D-allopyranosyl-(1→4)-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside, and drebyssogenin K2 3-O-3-O-methyl-6-deoxy-β-D-allopyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside, respectively.
    CONCLUSIONS:
    Among them, 1 and 2 were active against Ehrlich carcinoma (solid type), and the latter was also active against melanoma B-16.