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Ecdysterone 2,3:20,22-diacetonide
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Ecdysterone 2,3:20,22-diacetonide
Price:
CAS No.: 22798-98-7
Catalog No.: CFN98230
Molecular Formula: C33H52O7
Molecular Weight: 560.8 g/mol
Purity: >=98%
Type of Compound: Steroids
Physical Desc.: Cryst.
Source: The roots of Cyanotis arachnoidea C. B. Clarke
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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Biological Activity
Description: Due to the multi-drug resistance reversal activity of the less polar ecdysteroids, several new products( including 20-hydroxyecdysone,20-hydroxyecdysone 2,3;20,22-diacetonide) are promising for being tested against various cancer cell lines.
Ecdysterone 2,3:20,22-diacetonide Description
Source: The roots of Cyanotis arachnoidea C. B. Clarke
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7832 mL 8.9158 mL 17.8317 mL 35.6633 mL 44.5792 mL
5 mM 0.3566 mL 1.7832 mL 3.5663 mL 7.1327 mL 8.9158 mL
10 mM 0.1783 mL 0.8916 mL 1.7832 mL 3.5663 mL 4.4579 mL
50 mM 0.0357 mL 0.1783 mL 0.3566 mL 0.7133 mL 0.8916 mL
100 mM 0.0178 mL 0.0892 mL 0.1783 mL 0.3566 mL 0.4458 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Anticancer Res. 2012 Apr;32(4):1291-7.
Rapid, laser-induced conversion of 20-hydroxyecdysone and its diacetonide -- experimental set-up of a system for photochemical transformation of bioactive substances.[Pubmed: 22493361]

METHODS AND RESULTS:
20-hydroxyecdysone (20E), the most common ecdysteroid in Nature, and the easily obtained derivative 20-hydroxyecdysone 2,3;20,22-diacetonide (20ED), at different concentrations, were exposed to a 266 nm laser beam at an energy level of 6.5 mJ for different periods of time and evaluated for fluorescence emission during the process of irradiation. The products of irradiation were scanned from 200 to 1500 nm and then subjected to one-dimensional and two-dimensional thin layer chromatography. During irradiation, progressive significant changes in the fluorescence emission spectra were noted for both compounds with time that were accompanied by changes in their UV-Vis spectra. Full conversion of both compounds was reached within 14 minutes, and both compounds yielded several major products and several minor ones representing a wide polarity range.
CONCLUSIONS:
The photo-transformation system described here was proven to be a useful and flexibly adjustable tool for the laser-catalyzed conversion of bioactive compounds. Due to the multi-drug resistance reversal activity of the less polar ecdysteroids, several new products are promising for being tested against various cancer cell lines. Fractionation, isolation and characterization of the irradiated products are currently in process.
Brevilin A

Catalog No: CFN99694
CAS No: 16503-32-5
Price: $128/20mg
Carnosic acid

Catalog No: CFN99102
CAS No: 3650-09-7
Price: $40/20mg
Martynoside

Catalog No: CFN97159
CAS No: 67884-12-2
Price: $338/5mg
Quercetin-7-O-beta-D-glucopyranoside

Catalog No: CFN99771
CAS No: 491-50-9
Price: $318/10mg
Berberine

Catalog No: CFN98049
CAS No: 2086-83-1
Price: $40/20mg
Mulberroside F

Catalog No: CFN90794
CAS No: 193483-95-3
Price: $288/10mg
Peonidin-3-O-arabinoside chloride

Catalog No: CFN92047
CAS No: 524943-91-7
Price: $318/5mg
Isovitexin 2''-O-arabinoside

Catalog No: CFN90943
CAS No: 53382-71-1
Price: $318/10mg
Ganoderic acid H

Catalog No: CFN92056
CAS No: 98665-19-1
Price: $318/10mg
Pseudoprotodioscin

Catalog No: CFN90694
CAS No: 102115-79-7
Price: $138/20mg
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