ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
How to Order
Orders via your E-mail:
1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Sent to Email: email@example.com
Order & Inquiry & Tech Support
Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
Delivery & Payment method
1. Usually delivery time: Next day delivery by 9:00 a.m. Order now
2. We accept: Wire transfer & Credit card & Paypal & Western Union
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $368 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Korean Journal of Pharmacognosy...2014...Food Science and Biotechnology...2015...Inflammation2015, 38(1):445-55Am J Chin Med.2016, 44(6):1255-1271Int. Conference on Med. Sci. and ...2017...J Ethnopharmacol.2017, 197:157-164Food Chem.2017, 221:1135-1144Invest New Drugs.2017, 35(2):166-179
PLoS One.2018, 13(11):e0208055J Pharm Biomed Anal.2018, 151:32-41Exp Neurobiol.2018, 27(3):200-209RSC Adv.2018, 32621-32636Sci Rep. 2018, 462(8)Chemistry of Natural Compounds...2018...Front Pharmacol.2019, 10:1355Mol Microbiol.2019, 112(1):317-332
Molecules.2019, 24(17):E3127Food Chem.2019, 278:683-691Chemistry of Plant Raw Materials...2019...Phytomedicine.2019, 55:229-237Food Funct.2020, 10.1039Plant Cell Tiss Org2020, 1-16Food Res Int.2020, 128:108778
Our products had been exported to the following research institutions and universities, And still growing.
University of Brasilia (Brazil)Mendel University in Brno (Czech Republic)Universite Libre de Bruxelles (Belgium)The Ohio State University (USA)
Weizmann Institute of Science (Israel)Korea Food Research Institute(K... (Korea)Universidad de La Salle (Mexico)University of Wisconsin-Madison (USA)
University of the Basque Country (Spain)University of Canterbury (New Zealand)Srinakharinwirot University (Thailand)
Related Screening Libraries
||(-)-Epigallocatechin-3-(3''-O-methyl)gallate shows antioxidative,
cytotoxic, antiallergic, and anti-inflammatory activities, it can negatively regulate basophil activation through the suppression of FcepsilonRI expression. Epigallocatechin-3-(3''-O-methyl)gallate has the function for cold preservation of primary rat hepatocytes. |
||Immunology & Inflammation related|
|Agr. Biol. Chem., 2000, 64(10):2218-20. |
|Antioxidative activity of (-)-epigallocatechin-3-(3''-O-methyl)gallate isolated from fresh tea leaf and preliminary results on its biological activity.[Pubmed: 11129598 ]|
|Antioxidative activity of (-)-Epigallocatechin-3-(3''-O-methyl) gallate (catechine) was examined. |
METHODS AND RESULTS:
Catechine showed a strong antioxidative activity. A preliminary test using rat cancer cells suggests that catechin e also has a strong cytotoxic activity. Among tested catechins, only catechin e has strong activity for both.
|J. Agr. Food Chem., 2002, 50(20):5729-34. |
|Antiallergic tea catechin, (-)-epigallocatechin-3-O-(3-O-methyl)-gallate, suppresses FcepsilonRI expression in human basophilic KU812 cells.[Pubmed: 12236706]|
|We previously found that the O-methylated derivative of (-)-Epigallocatechin-3-O-gallate (EGCg),
(-)-epigallocatechin-3-O-(3-O-methyl)-gallate (EGCG' '3Me), has potent antiallergic activity. |
METHODS AND RESULTS:
The high-affinity IgE receptor, FcepsilonRI, is found at high levels on basophils and mast cells and plays a key role in a series of acute and chronic human allergic reactions. To understand the mechanism of action for the antiallergic EGCG' '3Me, the effect of EGCG' '3Me on the cell surface expression of FcepsilonRI in human basophilic KU812 cells was examined. Flow cytometric analysis showed that EGCG' '3Me was able to decrease the cell surface expression of FcepsilonRI. Moreover, immunoblot analysis revealed that total cellular expression of the FcepsilonRI alpha chain decreased upon treatment with EGCG' '3Me. FcepsilonRI is a tetrameric structure comprising one alpha chain, one beta chain, and two gamma chains. The level of mRNA production of each subunit in KU812 cells was investigated. EGCG' '3Me reduced FcepsilonRI alpha and gamma mRNA levels. The cross-linkage of FcepsilonRI causes the activation of basophils, which leads to the secretion of inflammatory mediators including histamine. EGCG' '3Me treatment inhibited the FcepsilonRI cross-linking-induced histamine release.
These results suggested that EGCG' '3Me can negatively regulate basophil activation through the suppression of FcepsilonRI expression.
(-)-Epigallocatechin-3-(3''-O-methyl) gallate Description
||The leaves of Camellia sinensis
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.