• ChemFaces is a professional high-purity natural products manufacturer.
  • Product Intended Use
  • 1. Reference standards
  • 2. Pharmacological research
  • 3. Inhibitors
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • Natural Products
    (-)-Epigallocatechin-3-(3''-O-methyl) gallate
    Information
    CAS No. 83104-87-4 Price $408 / 5mg
    Catalog No.CFN92081Purity>=98%
    Molecular Weight472.4Type of CompoundFlavonoids
    FormulaC23H20O11Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $368 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • University of Brasilia (Brazil)
  • Mendel University in Brno (Czech Republic)
  • Universite Libre de Bruxelles (Belgium)
  • The Ohio State University (USA)
  • Weizmann Institute of Science (Israel)
  • Korea Food Research Institute(K... (Korea)
  • Universidad de La Salle (Mexico)
  • University of Wisconsin-Madison (USA)
  • University of the Basque Country (Spain)
  • University of Canterbury (New Zealand)
  • Srinakharinwirot University (Thailand)
  • More...
  • Package
    Featured Products
    Ganoderiol F

    Catalog No: CFN99244
    CAS No: 114567-47-4
    Price: $398/5mg
    Alisol A 23-acetate

    Catalog No: CFN92544
    CAS No: 19865-75-9
    Price: $418/5mg
    Tangeretin

    Catalog No: CFN90240
    CAS No: 481-53-8
    Price: $40/20mg
    Hesperetin

    Catalog No: CFN98842
    CAS No: 520-33-2
    Price: $40/20mg
    20R-Ginsenoside Rg2

    Catalog No: CFN90412
    CAS No: 80952-72-3
    Price: $298/20mg
    Chrysosplenol D

    Catalog No: CFN99622
    CAS No: 14965-20-9
    Price: $268/10mg
    Picroside III

    Catalog No: CFN99567
    CAS No: 64461-95-6
    Price: $228/20mg
    Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Anti-inflammatory Compound Library
  • Antioxidants Compound Library
  • Cytotoxic Compound Library
  • Anti-allergy Compound Library
  • Cryoprotectants Compound Library
  • Flavonoids Compound Library
  • Immunology & Inflammation related Inhibitor Library
  • Biological Activity
    Description: (-)-Epigallocatechin-3-(3''-O-methyl)gallate shows antioxidative, cytotoxic, antiallergic, and anti-inflammatory activities, it can negatively regulate basophil activation through the suppression of FcepsilonRI expression. Epigallocatechin-3-(3''-O-methyl)gallate has the function for cold preservation of primary rat hepatocytes.
    Targets: Immunology & Inflammation related
    In vitro:
    Agr. Biol. Chem., 2000, 64(10):2218-20.
    Antioxidative activity of (-)-epigallocatechin-3-(3''-O-methyl)gallate isolated from fresh tea leaf and preliminary results on its biological activity.[Pubmed: 11129598 ]
    Antioxidative activity of (-)-Epigallocatechin-3-(3''-O-methyl) gallate (catechine) was examined.
    METHODS AND RESULTS:
    Catechine showed a strong antioxidative activity. A preliminary test using rat cancer cells suggests that catechin e also has a strong cytotoxic activity. Among tested catechins, only catechin e has strong activity for both.
    J. Agr. Food Chem., 2002, 50(20):5729-34.
    Antiallergic tea catechin, (-)-epigallocatechin-3-O-(3-O-methyl)-gallate, suppresses FcepsilonRI expression in human basophilic KU812 cells.[Pubmed: 12236706]
    We previously found that the O-methylated derivative of (-)-Epigallocatechin-3-O-gallate (EGCg), (-)-epigallocatechin-3-O-(3-O-methyl)-gallate (EGCG' '3Me), has potent antiallergic activity.
    METHODS AND RESULTS:
    The high-affinity IgE receptor, FcepsilonRI, is found at high levels on basophils and mast cells and plays a key role in a series of acute and chronic human allergic reactions. To understand the mechanism of action for the antiallergic EGCG' '3Me, the effect of EGCG' '3Me on the cell surface expression of FcepsilonRI in human basophilic KU812 cells was examined. Flow cytometric analysis showed that EGCG' '3Me was able to decrease the cell surface expression of FcepsilonRI. Moreover, immunoblot analysis revealed that total cellular expression of the FcepsilonRI alpha chain decreased upon treatment with EGCG' '3Me. FcepsilonRI is a tetrameric structure comprising one alpha chain, one beta chain, and two gamma chains. The level of mRNA production of each subunit in KU812 cells was investigated. EGCG' '3Me reduced FcepsilonRI alpha and gamma mRNA levels. The cross-linkage of FcepsilonRI causes the activation of basophils, which leads to the secretion of inflammatory mediators including histamine. EGCG' '3Me treatment inhibited the FcepsilonRI cross-linking-induced histamine release.
    CONCLUSIONS:
    These results suggested that EGCG' '3Me can negatively regulate basophil activation through the suppression of FcepsilonRI expression.
    (-)-Epigallocatechin-3-(3''-O-methyl) gallate Description
    Source: The leaves of Camellia sinensis
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Recent ChemFaces New Products and Compounds
    Kakkalide

    Catalog No: CFN95052
    CAS No: 58274-56-9
    Price: $260/10mg
    Isorubrofusarin 10-gentiobioside

    Catalog No: CFN95119
    CAS No: 200127-93-1
    Price: $338/10mg
    Tubuloside A

    Catalog No: CFN90669
    CAS No: 112516-05-9
    Price: $218/20mg
    Orcinol 1-O-beta-D-apiofuranosyl-(...

    Catalog No: CFN95109
    CAS No: 868557-54-4
    Price: $338/5mg
    Leachianol F

    Catalog No: CFN95147
    CAS No: 164123-50-6
    Price: $318/5mg
    Betmidin

    Catalog No: CFN95047
    CAS No: 35589-22-1
    Price: $413/5mg
    Ganoderic acid L

    Catalog No: CFN95022
    CAS No: 102607-24-9
    Price: $413/5mg
    Buddlenoid A

    Catalog No: CFN95025
    CAS No: 142750-32-1
    Price: $368/5mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1169 mL 10.5843 mL 21.1685 mL 42.337 mL 52.9213 mL
    5 mM 0.4234 mL 2.1169 mL 4.2337 mL 8.4674 mL 10.5843 mL
    10 mM 0.2117 mL 1.0584 mL 2.1169 mL 4.2337 mL 5.2921 mL
    50 mM 0.0423 mL 0.2117 mL 0.4234 mL 0.8467 mL 1.0584 mL
    100 mM 0.0212 mL 0.1058 mL 0.2117 mL 0.4234 mL 0.5292 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.