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Euphohelioscopin A
Euphohelioscopin A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Euphohelioscopin A
Price:
CAS No.: 87064-61-7
Catalog No.: CFN96233
Molecular Formula: C30H42O6
Molecular Weight: 498.7 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The herbs of Euphorbia helioscopia
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Euphohelioscopin A, an activator of protein kinase C (PKC), it inhibits proliferation and induces differentiation of the myeloid leukemia cell lines THP-1 and HL-60. Euphohelioscopin A has anti-inflammary activity, it exhibits moderate inhibitory activity on the release of cytokine TNF-α (IC50 = 23.7 ± 1.7 uM), IL-6 (IC50 = 46.1 ± 1.1 uM) and chemokine MCP-1 (IC50 = 33.7 ± 3.8 uM) in lipopolysaccharide (LPS) induced RAW 264.7 macrophages without notable cytotoxicity (IC50 > 80 uM).
Targets: TNF-α | IL-6 Receptor | PKC | MCP-1
In vitro:
Nat Prod Commun. 2015 Dec;10(12):2037-9.
Macrocyclic Diterpenoids from the Latex of Euphorbia helioscopia.[Pubmed: 26882659]

METHODS AND RESULTS:
One new jatrophane diterpenoid, 7α,9β,15β-triacetoxy-3β-benzoyloxy-14β-hydroxyjatropha-5E,11E-diene (3), together with four known macrocyclic diterpenoids, euphoheliosnoid A (1), epieuphoscopin B (2), Euphohelioscopin A (4) and euphoscopin C (5), were isolated from the stem latex of Euphorbia helioscopia. Their structures were established by spectroscopic analyses.
CONCLUSIONS:
In the anti-inflammatory assay, Euphohelioscopin A (4) exhibited moderate inhibitory activity on the release of cytokine TNF-α (IC50 = 23.7 ± 1.7 μM), IL-6 (IC50 = 46.1 ± 1.1 μM) and chemokine MCP-1 (IC50 = 33.7 ± 3.8 μM) in lipopolysaccharide (LPS) induced RAW 264.7 macrophages without notable cytotoxicity (IC50 > 80 μM).
Chem Biol. 2012 Aug 24;19(8):994-1000.
Euphohelioscopin A is a PKC activator capable of inducing macrophage differentiation.[Pubmed: 22921066 ]
To identify small molecules that selectively control hematopoietic stem cell differentiation, we performed an unbiased screen using primary human CD34(+) cells.
METHODS AND RESULTS:
We identified a plant-derived natural product, Euphohelioscopin A, capable of selectively differentiating CD34(+) cells down the granulocyte/monocytic lineage. Euphohelioscopin A also inhibits proliferation and induces differentiation of the myeloid leukemia cell lines THP-1 and HL-60.
CONCLUSIONS:
Mechanistic studies revealed that Euphohelioscopin A is an activator of protein kinase C (PKC), and that the promonocytic effects of this natural product are mediated by PKC activation. In addition to shedding insights into normal hematopoiesis, this work may ultimately facilitate the application of stem cell therapies to a host of myeloid dysfunctions.
Euphohelioscopin A Description
Source: The herbs of Euphorbia helioscopia
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
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ACS Nano. 2018 Apr 24;12(4): 3385-3396.
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IF=13.903(2019)

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Nature Plants. 2016 Dec 22;3: 16206.
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IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0052 mL 10.0261 mL 20.0521 mL 40.1043 mL 50.1303 mL
5 mM 0.401 mL 2.0052 mL 4.0104 mL 8.0209 mL 10.0261 mL
10 mM 0.2005 mL 1.0026 mL 2.0052 mL 4.0104 mL 5.013 mL
50 mM 0.0401 mL 0.2005 mL 0.401 mL 0.8021 mL 1.0026 mL
100 mM 0.0201 mL 0.1003 mL 0.2005 mL 0.401 mL 0.5013 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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