| In vitro: |
| Phytochemistry. 1997 Jul;45(6):1207-12. | | Prenylated phenylpropenes from Coleonema pulchellum with antimicrobial activity.[Pubmed: 9272968 ] | The lipophilic root extract of Coleonema pulchellum was analysed and tested for antifungal and antibacterial activity.
METHODS AND RESULTS:
Eight previously undescribed prenyloxy and geranyloxy phenylpropenes, were isolated as major compounds together with the known Evofolin C as well as the lignans (+/-)-sesamin and (+/-)-prenylpiperitol, the diterpene (-)-pimara-9(11),15-dien-19-oic acid and the 2,4-decadienoic acid isobutylamide. All structures were established by spectroscopic evidence.
CONCLUSIONS:
From the new phenylpropenes, named Evofolin C-acetate, colenemol, colenemal, prenycol acetate, dehydroprenycol acetate, precolpuchol, colpuchol and colpuchol acetate, the dihydroxylated precolpuchol displayed the strongest antifungal and antibacterial activity against Cladosporium herbarum and Staphylococcus aureus, respectively. | | J Nat Prod. 2007 Sep;70(9):1444-8. | | New phenylpropenoids, bis(1-phenylethyl)phenols, bisquinolinone alkaloid, and anti-inflammatory constituents from Zanthoxylum integrifoliolum.[Pubmed: 17822293 ] |
METHODS AND RESULTS:
Five new compounds, including two new phenylpropenoids, (R,E)-1-[4-(3-hydroxyprop-1-enyl)phenoxy]-3-methylbutane-2,3-diol (1) and 4-hydroxy-3-(3-methyl-2-butenyl)cinnamyl alcohol (2), two new bis(1-phenylethyl)phenols, 2,6-bis(1-phenylethyl)phenol (3) and 2,4-bis(1-phenylethyl)phenol (4), and a new bisquinolinone alkaloid, 18-demethylparaensidimerin C (5), together with 17 known compounds have been isolated from the stem wood of Zanthoxylum integrifoliolum. The structures of these new compounds were determined through spectral analyses including extensive 2D nuclear magnetic resonance data.
CONCLUSIONS:
Among the isolates, N-methylflindersine (7), (-)-simulanol (10), and Evofolin C (16) exhibited potent inhibition against N-formylmethionylleucylphenylalanine-induced superoxide production with IC(50) values less than 12 microM. |
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