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    Fuziline
    Information
    CAS No. 80665-72-1 Price $238 / 20mg
    Catalog No.CFN90689Purity>=98%
    Molecular Weight453.58Type of CompoundAlkaloids
    FormulaC24H39NO7Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Fuziline shows significant insecticidal activity against Nilaparvata legen and Aphis medicagini. Fuziline shows activity against pentobarbital sodiuminduced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability.
    Targets: Antifection
    In vitro:
    Molecules, 2012, 17(8):9939-46.
    Alkaloids isolated from the lateral root of Aconitum carmichaelii.[Pubmed: 22907155 ]
    Two new alkaloids, aconicarmine (1) and aconicaramide (5), were isolated from the EtOH extract of the lateral roots of Aconitum carmichaelii, together with five known compounds: Fuziline (2), neoline (3), N-ethylhokbusine B (4), 5-hydroxymethylpyrrole-2-carbaldehyde (6), and oleracein E (7).
    METHODS AND RESULTS:
    Their structures were elucidated by physical and NMR analysis. Pyrrole alkaloids were isolated from A. carmichaelii for the first time. In the in vitro assays, compounds 2 and 3 showed activity against pentobarbital sodiuminduced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability, while compounds 5 and 7 showed moderate antibacterial activity.
    In vivo:
    《Pharmacy and Clinics of Chinese Materia Medica》 2014-03
    The pharmacological research progress of Fuziline and Neoline[Reference: WebLink]
    By analyzing and summarizing pharmacological research literature about Fuziline and Neoline,the pharmacological research of both drugs are found to be mainly concentrated on the cardiovascular system,analgesia,anesthesia,antitumor,insecticidal,and so on.At the same time,Fuziline and Neoline are lack of a comprehensive and systematic pharmacological research.
    Biomed Chromatogr. 2014 Dec;28(12):1707-13.
    Development and validation of a UHPLC-qTOF-MS method for quantification of fuziline in rat plasma and its application in a pharmacokinetic study.[Pubmed: 24782408]

    METHODS AND RESULTS:
    A specific and sensitive UHPLC-qTOF-MS method was developed and validated for quantification of Fuziline in rat plasma after oral administration of three dosages. The analyte was separated on an Acquity UPLC BEH C18 column with a total running time of 3 min using a mobile phase of 0.1% formic acid aqueous solution and methanol (80:20, v/v) at a flow-rate of 0.25 mL/min. The calibration curves for Fuziline showed good linearity in the concentrations ranging from 1 to 200 ng/mL with correlation coefficients >0.997. The precision, accuracy, recovery and stability were deemed acceptable. The method was applied to a pharmacokinetics study of Fuziline in rats. The mean half-life was 5.93, 6.13 and 5.12 h for 1, 2 and 4 mg/kg oral administration of Fuziline, respectively. The peak concentration and area under the concentration-time curve increased linearly with the doses.
    CONCLUSIONS:
    The sum of these results indicated that, in the range of the doses examined, the pharmacokinetics of Fuziline in rat was based on first-order kinetics.
    Fuziline Description
    Source: The roots of Aconitum carmichaeli Debx.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2047 mL 11.0234 mL 22.0468 mL 44.0937 mL 55.1171 mL
    5 mM 0.4409 mL 2.2047 mL 4.4094 mL 8.8187 mL 11.0234 mL
    10 mM 0.2205 mL 1.1023 mL 2.2047 mL 4.4094 mL 5.5117 mL
    50 mM 0.0441 mL 0.2205 mL 0.4409 mL 0.8819 mL 1.1023 mL
    100 mM 0.022 mL 0.1102 mL 0.2205 mL 0.4409 mL 0.5512 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.