GB 1a | CAS:220611-41-6 | Manufacturer ChemFaces

GB 1a

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Description:

GB 1a shows potential in vitro antioxidant activities.

Targets:

Tyrosinase

In vitro:

Nat Prod Res. 2016;30(2):232-6.

Phytochemical analysis and antioxidant potential of the leaves of Garcinia travancorica Bedd.[Pubmed: 25982126 ]

METHODS AND RESULTS:
Phytochemical analysis of the leaves of Garcinia travancorica, a hitherto uninvestigated endemic species to the Western Ghats of south India, resulted in isolation and characterisation of the polyisoprenylated benzophenones 7-epi-nemorosone (1) and garcinol (2) along with biflavonoids GB 1a (3), GB-1 (4), GB-2 (5), morelloflavone (6) and morelloflavone-7″-O-β-D-glycoside or fukugiside (7). The compounds were identified using various spectroscopic techniques, mainly through NMR and MS. The methanol extract and the biflavonoids 3, 4, 5 and 7 showed potential in vitro antioxidant activities. The IC50 value of the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity of compound 7 was 8.34 ± 2.12 μg/mL, comparable to that of standard ascorbic acid (3.2 ± 0.50 μg/mL). In the superoxide radical scavenging assay, compound 7 gave IC50 value of 6.95 ± 1.33 μg/mL close to standard ascorbic acid with IC50 value of 5.8 ± 0.25 μg/mL.
CONCLUSIONS:
Validated HPTLC estimation revealed G. travancorica as a rich source of morelloflavone-7″-O-β-D-glycoside (7.12% dry wt. leaves).

GB 1a Description

Source:	The leaves of Garcinia travancorica.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

J Chromatogr A. 2007 Jun 1;1151(1-2):45-50.

Preparative isolation and identification of tyrosinase inhibitors from the seeds of Garcinia kola by high-speed counter-current chromatography.[Pubmed: 17367799 ]

In continuation of our search for bioactive natural products that can be used for the treatment of dermatological disorders associated with melanin hyperpigmentation, 50 extracts/fractions from 21 families of medicinal plants from West and Central Africa were evaluated for inhibitory activity against tyrosinase (E:C:1.14.18.1), the rate-limiting enzyme in melanin synthesis.
METHODS AND RESULTS:
Four extracts including the methanol extract of Garcinia kola seeds at 100 microg/ml displayed >60% inhibition of tyrosinase activity. Preparative high-speed counter-current chromatography with solvent system composed of n-hexane-ethyl acetate-methanol-water (3:5:3:5) successfully separated the most active extract from G. kola seed. By stepwise increase of the flow-rate of the mobile phase, five major biflavanones including GB-I-glucoside (1) GB 1a (2), GB-1 (3), GB-2 (4), kolaflavonone (5) were successfully isolated in 6 h.
CONCLUSIONS:
Compound (4) was the most potent (IC(50) 582 microM) and compared favorably with a reference tyrosinase inhibitor (kojic acid, IC(50) 130 microM).

Product Name	GB 1a
Price:
CAS No.:	220611-41-6
Catalog No.:	CFN96934
Molecular Formula:	C₃₀H₂₂O₁₀
Molecular Weight:	542.49 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The leaves of Garcinia travancorica.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antioxidants Compound Library Flavonoids Compound Library Tyrosinase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.8434 mL	9.2168 mL	18.4335 mL	36.867 mL	46.0838 mL
5 mM	0.3687 mL	1.8434 mL	3.6867 mL	7.3734 mL	9.2168 mL
10 mM	0.1843 mL	0.9217 mL	1.8434 mL	3.6867 mL	4.6084 mL
50 mM	0.0369 mL	0.1843 mL	0.3687 mL	0.7373 mL	0.9217 mL
100 mM	0.0184 mL	0.0922 mL	0.1843 mL	0.3687 mL	0.4608 mL

CFN96541	Taiwanhomoflavone A	265120-00-1	580.55	C₃₃H₂₄O₁₀
CFN99025	3,8'-Biapigenin	101140-06-1	538.5	C₃₀H₁₈O₁₀
CFN96934	GB 1a	220611-41-6	542.49	C₃₀H₂₂O₁₀
CFN89091	GB 1b	19360-72-6	542.49	C₃₀H₂₂O₁₀
CFN89133	GB 2a	18412-96-9	558.49	C₃₀H₂₂O₁₁
CFN92960	Wikstrol A	159736-35-3	542.49	C₃₀H₂₂O₁₀
CFN70356	Cupressuflavone	3952-18-9	538.5	C₃₀H₁₈O₁₀
CFN97224	4',4'''-Di-O-methylcupressuflavone	74336-91-7	566.5	C₃₂H₂₂O₁₀
CFN95007	8,8''-Bibaicalein	135309-02-3	538.5	C₃₀H₁₈O₁₀
CFN96555	Acuminatanol	948884-38-6	638.49	C₃₀H₂₂O₁₆