ChemFaces is a professional high-purity natural products manufacturer.
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More articles cited ChemFaces products.
Chem Biol Interact.2018 Mar 1;J Pharm Biomed Anal.2018 Mar 20;Phytochemistry Letters2015 JunePhytother Res.2015 Apr 17.Plant J. 2017 May;
J Biochem Mol Toxicol. 2017 Jun 7Sci Rep. 2016; 6: 25094.2016 Apr 27;6:25094. Mol. & Cell. ToxicologySep. 2017;ScientificWorldJournal. 2014 Feb 9.Journal of Life Science2017.2;
FEMS Microbiol Lett. 2017 Jun 15;Planta Med 2016 Apr 28.Braz J Med Biol Res. 2016 Jul 4;49(7).J Ethnopharmacol.2018 Jan 10;
Our products had been exported to the following research institutions and universities, And still growing.
Seoul National University of Sci... (Korea)Universidad de Ciencias y Artes ... (Mexico)Universitas Airlangga (Indonesia)University of Maryland (USA)
Max Rubner-Institut (MRI) (Germany)University of Wisconsin-Madison (USA)Shanghai University of TCM (China)University of Amsterdam (Netherlands)
Universidade do Porto (Portugal)Northeast Normal University Chan... (China)Universidade de Franca (Brazil)
|| Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments. |
||AChE | IL Receptor|
|European Journal of Drug Metabolism and Pharmacokinetics,1987,12(1):25-30. |
|In vitro metabolism of galanthamine hydrobromide (Nivalin®) by rat and rabbit liver homogenate[Reference: WebLink]|
|The metabolism of galanthamine hydrobromide (Nivalin®) was investigated in rat and rabbit liver homogenates.
METHODS AND RESULTS:
Experiments were carried out varying several parameters of incubation: substrate (galanthamine hydrobromide, galanthamine, Galanthaminone and epigalanthamine), cofactor enrichment (NADPH, NADP/G-6-P, NAD), pH (7.4 and 9.3), time of incubation. Substrates and metabolites were identified and quantitatively determined by GC/MS. In vitro metabolism in rat liver homogenate was negligible. The experiments with rabbit liver homogenate indicated, that galanthamine was actively metabolised the major metabolites being the oxidised product — Galanthaminone, and the isomer of galanthamine — epigalantamine.
The experimental results show that the metabolism of galanthamine is substrate and product stereoselective.
|Clin Pharmacol Ther. 1991 Oct;50(4):420-8. |
|Pharmacokinetics of galanthamine in humans and corresponding cholinesterase inhibition.[Pubmed: 1914378]|
METHODS AND RESULTS:
Measurements were done to determine the plasma concentrations of galanthamine and two of its metabolites, as well as the corresponding inhibition of acetylcholinesterase activity in erythrocytes after applying 5 and 10 mg galanthamine hydrobromide as a constant-rate intravenous infusion for 30 minutes and single oral doses of 10 mg in eight healthy male volunteers.
The data obtained revealed first-order pharmacokinetics, complete oral bioavailability, and a mean terminal half-life of 5.68 hours (95% confidence interval, 5.17 to 6.25 hours). Renal clearance accounted for only 25% of the total plasma clearance (CL = 0.34 L.kg-1.hr-1). Only negligible quantities of the putative metabolites, epigalanthamine and Galanthaminone, were detected in blood and urine. The inhibition of acetylcholinesterase activity was closely correlated with the pharmacokinetics of galanthamine, a median maximal value of 53% being achieved by applying 10 mg galanthamine intravenously.
Analysis of in vitro and ex vivo concentration responses revealed no differences, indicating that no metabolites of galanthamine exert additional inhibition of acetylcholinesterase activity.
||The bulbs of Lycoris radiata
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Pharmaceutical Bulletin 12(6), 696-705, 1964 |
|Galanthamine Chemistry. V. Formation of Hydroxyapogalanthamine from Galanthaminone and the Synthesis of its Trimethyl Ether.[Reference: WebLink]|
METHODS AND RESULTS:
Treatment of Galanthaminone with hydriodic acid gave hydroxyapogalanthamine, the structure of which has been elucidated by degradation to the known diphenic acid (IV). The trimethyl ether of hydroxyapogalanthamine has been synthesized by two methods, confirming the structure of this important transformation product of Galanthaminone.
Based on this and other chemical evidence it has been concluded that galanthamine is represented by formula (III).