|Description:||1. Ganoderic acid Y significantly inhibits the replication of the viral RNA (vRNA) of EV71 replication through blocking EV71 uncoating.|
|Source:||The fruit body of Ganoderma lucidum|
|Solvent:||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||2.1993 mL||10.9967 mL||21.9935 mL||43.987 mL||54.9837 mL|
|5 mM||0.4399 mL||2.1993 mL||4.3987 mL||8.7974 mL||10.9967 mL|
|10 mM||0.2199 mL||1.0997 mL||2.1993 mL||4.3987 mL||5.4984 mL|
|50 mM||0.044 mL||0.2199 mL||0.4399 mL||0.8797 mL||1.0997 mL|
|100 mM||0.022 mL||0.11 mL||0.2199 mL||0.4399 mL||0.5498 mL|
Biochem Biophys Res Commun. 2014 Jul 4;449(3):307-12.
|Antiviral effects of two Ganoderma lucidum triterpenoids against enterovirus 71 infection.[Pubmed: 24845570]|
|We evaluated the antiviral activities of two Ganoderma lucidum triterpenoids (GLTs), Lanosta-7,9(11),24-trien-3-one,15;26-dihydroxy (GLTA) and Ganoderic acid Y (GLTB), against EV71 infection.The results suggested that GLTA and Ganoderic acid Y prevent EV71 infection through interacting with the viral particle to block the adsorption of virus to the cells. In addition, the interactions between EV71 virion and the compounds were predicated by computer molecular docking, which illustrated that GLTA and Ganoderic acid Y may bind to the viral capsid protein at a hydrophobic pocket (F site), and thus may block uncoating of EV71. Moreover, we demonstrated that GLTA and Ganoderic acid Y significantly inhibit the replication of the viral RNA (vRNA) of EV71 replication through blocking EV71 uncoating. Thus, GLTA and GLTB may represent two potential therapeutic agents to control and treat EV71 infection.|
Appl Environ Microbiol. 2005 Jul;71(7):3653-8.
|Effect of 26-oxygenosterols from Ganoderma lucidum and their activity as cholesterol synthesis inhibitors.[Pubmed: 16000773]|
|Ganoderma lucidum is a medicinal fungus belonging to the Polyporaceae family which has long been known in Japan as Reishi and has been used extensively in traditional Chinese medicine. We report the isolation and identification of the 26-oxygenosterols ganoderol A, ganoderol B, ganoderal A, and Ganoderic acid Y and their biological effects on cholesterol synthesis in a human hepatic cell line in vitro.|