Gardneramine | CAS:34274-91-4 | Manufacturer ChemFaces

Gardneramine

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Description:

Gardneramine has a mild central depressive effect. Gardneramine and hirsutine show a local anesthetic action, they also can inhibit the ganglionic transmission of the dog urinary bladder and that the blockade of the nicotinic receptor plays a main role.

In vivo:

Jpn J Pharmacol. 1983 Apr;33(2):463-71.

Site of the ganglion blocking action of gardneramine and hirsutine in the dog urinary bladder in situ preparation.[Pubmed: 6193306]

METHODS AND RESULTS:
The ganglion blocking site of Gardneramine (GA) and hirsutine (HS) was studied in the dog urinary bladder in an in situ preparation. GA and HS selectively inhibited the DMPP-induced contraction without having an antagonistic effect on the McN-A-343-induced and acetylcholine-induced contraction. In addition, since GA and HS showed a local anesthetic action weaker than that of procaine, the effect of procaine was studied on the same preparation. Procaine inhibited the McN-A-343-induced contraction, and it slightly inhibited the DMPP-induced and acetylcholine-induced contraction.
CONCLUSIONS:
From these findings, it is concluded that GA and HS inhibited the ganglionic transmission of the dog urinary bladder and that the blockade of the nicotinic receptor played a main role.

Gardneramine Description

Source:	The roots of Gardneria multiflora Makino
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

Yakugaku Zasshi. 1971 Sep;91(9):997-1003.

Pharmacological Studies on Gardneria Alkaloids. II. Peripheral Effects (Effects on Circulatory and Digestive Systems)[Reference: WebLink]

Peripheral effects of Gardneramine and gardnerine on circulatory and digestive systems were examined.
METHODS AND RESULTS:
Gardneramine and gardnerine produced a hypotensive effect in the rabbit, which seemed to be derived from their peripheral vasodilataion, direct depressive action on myocardium, and central depressive action. Both alkaloids produced vasodilatation in the hind limb preparation of the dog and depressive action on atria isolated from the guinea pig. They produced a weak preventive effect on stress in the mouse, Gardneranine inhibited the movement of smooth muscle organs such as stomach of the rat and intestine of the mouse. On the contrary, gardnerine accelerated it with lower doses, inhibited with higher doses. Both alkaloids decreased slightly the pH value of gastric acidity in the rat and also produced a weak papaverine-like antispasmodic action in the intestine isolated from the mouse.
CONCLUSIONS:
From these results, it may be concluded that Gardneramine and gardnerine have a weak papaverine-like action on peripheral organs, the former being weaker than the latter. However, it is of interest to note that gardnerine accelerated the movement of smooth muscle of gastrointestinal tract with lower doses.

Product Name	Gardneramine
Price:
CAS No.:	34274-91-4
Catalog No.:	CFN98447
Molecular Formula:	C₂₃H₂₈N₂O₅
Molecular Weight:	412.5 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The roots of Gardneria multiflora Makino
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Local anaesthetics Compound Library Central nervous system depressant action Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.4242 mL	12.1212 mL	24.2424 mL	48.4848 mL	60.6061 mL
5 mM	0.4848 mL	2.4242 mL	4.8485 mL	9.697 mL	12.1212 mL
10 mM	0.2424 mL	1.2121 mL	2.4242 mL	4.8485 mL	6.0606 mL
50 mM	0.0485 mL	0.2424 mL	0.4848 mL	0.9697 mL	1.2121 mL
100 mM	0.0242 mL	0.1212 mL	0.2424 mL	0.4848 mL	0.6061 mL

CFN98447	Gardneramine	34274-91-4	412.5	C₂₃H₂₈N₂O₅
CFN96295	Quinamine	464-85-7	312.4	C₁₉H₂₄N₂O₂
CFN96329	Conquinamine	464-86-8	312.4	C₁₉H₂₄N₂O₂
CFN99043	Dihydrocinchonamine	10283-68-8	298.4	C₁₉H₂₆N₂O
CFN98823	Neoechinulin A	51551-29-2	323.4	C₁₉H₂₁N₃O₂
CFN99862	Echinulin	1859-87-6	461.7	C₂₉H₃₉N₃O₂
CFN96445	Voafinidine	180059-77-2	328.45	C₂₀H₂₈N₂O₂
CFN96472	Tryprostatin A	171864-80-5	381.47	C₂₂H₂₇N₃O₃