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Gentiside J
Gentiside J
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Gentiside J
Price:
CAS No.: 1238837-50-7
Catalog No.: CFN89004
Molecular Formula: C29H50O4
Molecular Weight: 462.71 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Source: The whole plants of Gentiana rigescens Franch.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Gentiside J is a potent inducer of neurite outgrowth on PC12 cells.
Targets: NGF
Gentiside J Description
Source: The whole plants of Gentiana rigescens Franch.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1612 mL 10.8059 mL 21.6118 mL 43.2236 mL 54.0295 mL
5 mM 0.4322 mL 2.1612 mL 4.3224 mL 8.6447 mL 10.8059 mL
10 mM 0.2161 mL 1.0806 mL 2.1612 mL 4.3224 mL 5.403 mL
50 mM 0.0432 mL 0.2161 mL 0.4322 mL 0.8645 mL 1.0806 mL
100 mM 0.0216 mL 0.1081 mL 0.2161 mL 0.4322 mL 0.5403 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Bioorg Med Chem. 2010 Oct 1;18(19):6995-7000.
Gentisides C-K: nine new neuritogenic compounds from the traditional Chinese medicine Gentiana rigescens Franch.[Pubmed: 20813533 ]
Nine new alkyl 2,3-dihydroxybenzoates, gentisides C-K(gentiside C,gentiside D, gentiside E, gentiside F,gentiside G, gentiside H, gentiside I, Gentiside J, gentiside K), were isolated from the traditional Chinese medicine Gentiana rigescens Franch.
METHODS AND RESULTS:
Their structures and stereochemistry were elucidated by spectroscopic methods, and comparison of the specific rotation with that of the gentiside B. These metabolites are additional members of the gentisides which belong to a novel class of neuritogenic compounds. They are structurally different from one another because they possess varying alkyl chain lengths, with or without an isobutyl or isopropyl group at the end of the alkyl chain. These compounds are potent inducers of neurite outgrowth on PC12 cells. The gentiside C possessing the shortest alkyl chain length exhibited the highest neuritogenic activity among all of the gentisides. Gentiside C showed a significant neuritogenic activity at 1 μM against PC12 cells comparable to that seen for the best nerve growth factor (NGF) concentration of 40 ng/mL. In addition, evident neuritogenic activity was observed in the cells when treated with gentiside C at a concentration as low as 0.03 μM.
CONCLUSIONS:
The structure-activity relationships within the gentisides A-K revealed that alkyl chain length is important for the activity, but structure diversity at the end of the alkyl chain is not.
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Arctiin

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Price: $30/20mg
3-O-Feruloylquinic acid

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Vomifoliol

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CAS No: 23526-45-6
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Platycoside E

Catalog No: CFN90786
CAS No: 237068-41-6
Price: $ / mg
Pseudoprotodioscin

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Price: $138/20mg
Angeloylgomisin H

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CAS No: 66056-22-2
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Niga-ichigoside F1

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N-p-Coumaroyloctopamine

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