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Glycodeoxycholic acid
Glycodeoxycholic acid
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Glycodeoxycholic acid
Price: $100 / 20mg
CAS No.: 360-65-6
Catalog No.: CFN96947
Molecular Formula: C26H43NO5
Molecular Weight: 449.63 g/mol
Purity: >=98%
Type of Compound: Steroids
Physical Desc.: Powder
Source: The derivatives of deoxycholic acid and glycine.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / $42.3 / In-stock
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Glycodeoxycholic acid levels could as prognostic biomarker in acetaminophen-induced acute liver failure patients. Glycodeoxycholic acid can induce the apoptosis of SMMC-7721 cells.
Targets: p53
In vitro:
Chinese Journal of Clinical Laboratory Science, 2009, 27(3):167-169.
The effect of glycodeoxycholic acid on P53 expression in the apoptosis of SMMC-7721 cells[Reference: WebLink]
To investigate the effect of Glycodeoxycholic acid(GDCA) on apoptosis of and P53 expression in SMMC-7721 cells.
METHODS AND RESULTS:
Apoptotic rate was examined by Annexin V.P53 mRNA was analyzed by RT-PCR,and P53 protein was measured by immunohistochemistry technique.Compared with the control,SMMC-7721 cells treated with GDCA had significantly increased apoptotic rate in a dose-and time-dependent manner.After treated with 200 μmol/L GDCA,the apoptotic rates of the cells at 48 h and 72 h were(7.67±2.35)% and(12.93±1.48)% respectively.When the GDCA concentration was raised to 400 μmol/L,the apoptotic rates of the cells at 48 h and 72 h also increased to(13.14±2.56)% and(14.22±2.11)% respectively.The p53 mRNA in SMMC-7721 cells was up-regulated,whereas the mutant P53 protein was obviously inhibited after the cells were treated with GDCA.
CONCLUSIONS:
GDCA can induce the apoptosis of SMMC-7721 cells.
In vivo:
Toxicol Sci. 2014 Dec; 142(2): 436–444.
Glycodeoxycholic Acid Levels as Prognostic Biomarker in Acetaminophen-Induced Acute Liver Failure Patients[Pubmed: 25239633]
Acetaminophen (APAP)-induced acute liver failure (ALF) remains a major clinical problem. Although a majority of patients recovers after severe liver injury, a subpopulation of patients proceeds to ALF. Bile acids are generated in the liver and accumulate in blood during liver injury, and as such, have been proposed as biomarkers for liver injury and dysfunction. The goal of this study was to determine whether individual bile acid levels could determine outcome in patients with APAP-induced ALF (AALF).
METHODS AND RESULTS:
Serum bile acid levels were measured in AALF patients using mass spectrometry. Bile acid levels were elevated 5–80-fold above control values in injured patients on day 1 after the overdose and decreased over the course of hospital stay. Interestingly, Glycodeoxycholic acid (GDCA) was significantly increased in non-surviving AALF patients compared with survivors. GDCA values obtained at peak alanine aminotransferase (ALT) and from day 1 of admission indicated GDCA could predict survival in these patients by receiver-operating characteristic analysis (AUC = 0.70 for day 1, AUC = 0.68 for peak ALT). Of note, AALF patients also had significantly higher levels of serum bile acids than patients with active cholestatic liver injury.
CONCLUSIONS:
These data suggest measurements of GDCA in this patient cohort modestly predicted outcome and may serve as a prognostic biomarker. Furthermore, accumulation of bile acids in serum or plasma may be a result of liver cell dysfunction and not cholestasis, suggesting elevation of circulating bile acid levels may be a consequence and not a cause of liver injury.
Glycodeoxycholic acid Description
Source: The derivatives of deoxycholic acid and glycine.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.2241 mL 11.1203 mL 22.2405 mL 44.481 mL 55.6013 mL
5 mM 0.4448 mL 2.2241 mL 4.4481 mL 8.8962 mL 11.1203 mL
10 mM 0.2224 mL 1.112 mL 2.2241 mL 4.4481 mL 5.5601 mL
50 mM 0.0445 mL 0.2224 mL 0.4448 mL 0.8896 mL 1.112 mL
100 mM 0.0222 mL 0.1112 mL 0.2224 mL 0.4448 mL 0.556 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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