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Guaiol
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Product Name Guaiol
Price:
CAS No.: 489-86-1
Catalog No.: CFN96326
Molecular Formula: C15H26O
Molecular Weight: 222.4 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Oil
Source: The roots of Ferula ferulaeoides.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
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10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: (-)-Guaiol is a biocatalyst. Guaiol has insecticidal activity.
In vitro:
Nat Prod Commun. 2013 Oct;8(10):1353-4.
Guaiol--a naturally occurring insecticidal sesquiterpene.[Pubmed: 24354171]
The dichloromethane fraction of Ferula ferulaeoides was analyzed by GC and GC-MS, and thirty-four compounds were identified.
METHODS AND RESULTS:
The main component in the fraction, Guaiol (37.0%) was separated by chromatographic methods and identified from spectroscopic data, including 1H and 13C NMR, and X-ray crystallographic diffraction. Guaiol showed significant inhibition of aphids at a concentration of 70 mg/L. It also showed good contact activities against the 4th instar larvae of Mythimna separate and 3rd instar larvae of Plutella xylostella, with LD50 values of 0.07 and 8.9 mg/larva, as well as fumigation activity against the 4th instar larvae ofM. separata and adult Musca domestica, with LC50 values of 3.5 microL/L and 16.9 microL/L, respectively.
Guaiol Description
Source: The roots of Ferula ferulaeoides.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
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IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.4964 mL 22.482 mL 44.964 mL 89.9281 mL 112.4101 mL
5 mM 0.8993 mL 4.4964 mL 8.9928 mL 17.9856 mL 22.482 mL
10 mM 0.4496 mL 2.2482 mL 4.4964 mL 8.9928 mL 11.241 mL
50 mM 0.0899 mL 0.4496 mL 0.8993 mL 1.7986 mL 2.2482 mL
100 mM 0.045 mL 0.2248 mL 0.4496 mL 0.8993 mL 1.1241 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Nat Prod Res. 2006 Jul 10;20(8):731-4.
Biotransformation of (-)-guaiol by Eurotium rubrum as a biocatalyst.[Pubmed: 16753905]

METHODS AND RESULTS:
The biotransformation of (-)-Guaiol (1) has been investigated by using plant parasite fungus, Eurotium rubrum. Compound 1 was oxidized at the C-2 position, and transformed to pancherione.
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