Science | Nature | Cell | View More
Natural Products
Gymnemic acid I
Gymnemic acid I
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Gymnemic acid I
Price:
CAS No.: 122168-40-5
Catalog No.: CFN90538
Molecular Formula: C43H66O14
Molecular Weight: 806.97 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The herbs of Gymnema sylvestre (Retz.) Schult.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Chulalongkorn University (Thailand)
  • National Chung Hsing University (Taiwan)
  • Max-Planck-Insitut (Germany)
  • Universidad de La Salle (Mexico)
  • University of Brasilia (Brazil)
  • St. Jude Children Research Hosp... (USA)
  • Sri Ramachandra University (India)
  • Universidad de Ciencias y Artes... (Mexico)
  • Universite Libre de Bruxelles (Belgium)
  • Charles Sturt University (Denmark)
  • Sapienza University of Rome (Italy)
  • More...
Package
Featured Products
L-Phenylalanine

Catalog No: CFN93152
CAS No: 63-91-2
Price: $30/20mg
Ginsenoside Ra2

Catalog No: CFN93293
CAS No: 83459-42-1
Price: $218/5mg
Resveratrol

Catalog No: CFN98791
CAS No: 501-36-0
Price: $30/20mg
6''-O-Malonylgenistin

Catalog No: CFN90631
CAS No: 51011-05-3
Price: $348/5mg
Alismoxide

Catalog No: CFN99775
CAS No: 87701-68-6
Price: $258/20mg
Liquiritin apioside

Catalog No: CFN90707
CAS No: 74639-14-8
Price: $90/20mg
Lithospermic acid

Catalog No: CFN98546
CAS No: 28831-65-4
Price: $138/20mg
Piperine

Catalog No: CFN99919
CAS No: 94-62-2
Price: $30/20mg
Luteolin-7-O-glucoside

Catalog No: CFN98565
CAS No: 5373-11-5
Price: $60/20mg
Chrysin

Catalog No: CFN98741
CAS No: 480-40-0
Price: $40/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Gymnemic acid I is a protein biosynthesis inhibitor, it as antisweet principles.
In vitro:
Journal of Natural Products,2017, 80(4).
Determination of Gymnemic Acid I as a Protein Biosynthesis Inhibitor Using Chemical Proteomics.[Reference: WebLink]
The plant Gymnema sylvestre has been used widely in traditional medicine as a remedy for several diseases, and its leaf extract is known to contain a group of bioactive triterpene saponins belonging to the gymnemic acid class.
METHODS AND RESULTS:
Gymnemic acid I (1) is one of the main components among this group of secondary metabolites and is endowed with an interesting bioactivity profile. Since there is a lack of information about its specific biological targets, the full interactome of 1 was investigated through a quantitative chemical proteomic approach, based on stable-isotope dimethyl labeling. The ribosome complex was found to be the main partner of compound 1, and a full validation of the proteomics results was achieved by orthogonal approaches.
CONCLUSIONS:
Further biochemical and biological investigations revealed an inhibitory effect of 1 on the ribosome machinery.
In vivo:
J Cell Physiol . 2019 Jun;234(6):9370-9377.
Gymnemic acid I triggers mechanistic target of rapamycin-mediated β cells cytoprotection through the promotion of autophagy under high glucose stress[Pubmed: 30370588]
Abstract Gymnemic acid I (GA I) is a bioactive component of Gymnema sylvestre. It is an Indian traditional medicinal herb which has antidiabetic effect. However, the molecular mechanism is remaining to be elucidated. Here, we showed that high glucose promoted the rate of apoptosis, GA I decreased the apoptosis under the high glucose stress. Our further study explored that GA I increased the number of autophagosome and the ratio of light chain 3-I (LC3-I)/LC3-II in MIN-6 cells under the normal or high glucose stress by the methods of western blot analysis and immunofluorescence. It induced autophagy flux and inhibited the phosphorylation of mammalian target of rapamycin (mTOR) and ribosomal protein S6 kinase β-1 (p70 S6K/S6K1), which is a substrate of mTOR. GA I decreased the rate of apoptosis and the activity of caspase-3 under the high glucose stress. The inhibition of apoptosis and caspase-3 activity by GA I were increased after treating with autophagy inhibitor in mouse islet β cells MIN-6. Our data suggested that GA I-induced autophagy protected MIN-6 cells from apoptosis under high glucose stress via inhibition the phosphorylation activity of mTOR. Keywords: apoptosis; autophagy; gymnemic acid; high glucose.
Gymnemic acid I Description
Source: The herbs of Gymnema sylvestre (Retz.) Schult.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Odontoside

Catalog No: CFN95530
CAS No: 20300-50-9
Price: $318/5mg
Mirificin-4'-O-glucoside

Catalog No: CFN95091
CAS No: 168035-01-6
Price: $288/5mg
Physalin O

Catalog No: CFN95097
CAS No: 120849-18-5
Price: $413/5mg
3''-O-Galloylmyricitrin

Catalog No: CFN95057
CAS No: 143202-36-2
Price: $333/5mg
Bergaptol-beta-glucopyranoside

Catalog No: CFN95186
CAS No: 131623-13-7
Price: $318/10mg
Tembetarine

Catalog No: CFN95542
CAS No: 18446-73-6
Price: $318/5mg
(Z)-3,11-dimethy-7-methylene-9,14-...

Catalog No: CFN95402
CAS No: 1392202-57-1
Price: $318/10mg
5-O-Coumaroylquinic acid

Catalog No: CFN95507
CAS No: 32451-86-8
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.2392 mL 6.196 mL 12.392 mL 24.7841 mL 30.9801 mL
5 mM 0.2478 mL 1.2392 mL 2.4784 mL 4.9568 mL 6.196 mL
10 mM 0.1239 mL 0.6196 mL 1.2392 mL 2.4784 mL 3.098 mL
50 mM 0.0248 mL 0.1239 mL 0.2478 mL 0.4957 mL 0.6196 mL
100 mM 0.0124 mL 0.062 mL 0.1239 mL 0.2478 mL 0.3098 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Tetrahedron Letters, 1989, 30(9):1103-1106.
Structure studies of new antisweet constituents from Gymnema sylvestre.[Reference: WebLink]

METHODS AND RESULTS:
Gymnemic acid I , Gymnemic acid II , Gymnemic acid III and Gymnemic acid IV have been isolated from hot water extract of leaves of Gymnema sylvestre R. Br. as antisweet principles. The whole structures were determined by chemical and spectroscopic means.
L-Phenylalanine

Catalog No: CFN93152
CAS No: 63-91-2
Price: $30/20mg
Ginsenoside Ra2

Catalog No: CFN93293
CAS No: 83459-42-1
Price: $218/5mg
Resveratrol

Catalog No: CFN98791
CAS No: 501-36-0
Price: $30/20mg
6''-O-Malonylgenistin

Catalog No: CFN90631
CAS No: 51011-05-3
Price: $348/5mg
Alismoxide

Catalog No: CFN99775
CAS No: 87701-68-6
Price: $258/20mg
Liquiritin apioside

Catalog No: CFN90707
CAS No: 74639-14-8
Price: $90/20mg
Lithospermic acid

Catalog No: CFN98546
CAS No: 28831-65-4
Price: $138/20mg
Piperine

Catalog No: CFN99919
CAS No: 94-62-2
Price: $30/20mg
Luteolin-7-O-glucoside

Catalog No: CFN98565
CAS No: 5373-11-5
Price: $60/20mg
Chrysin

Catalog No: CFN98741
CAS No: 480-40-0
Price: $40/20mg
Tags: buy Gymnemic acid I | Gymnemic acid I supplier | purchase Gymnemic acid I | Gymnemic acid I cost | Gymnemic acid I manufacturer | order Gymnemic acid I | Gymnemic acid I distributor