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    Hederagonic acid
    Information
    CAS No. 466-01-3 Price
    Catalog No.CFN98696Purity>=98%
    Molecular Weight470.7 Type of CompoundTriterpenoids
    FormulaC30H46O4Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: 1. Hederagonic acid ,arjunolic acid, bayogenin, and 4-epi-hederagonic acid show moderate potency of glycogen phosphorylase inhibition with IC50 of 53-103 uM.
    Hederagonic acid Description
    Source: The root of Pulsatilla chinensis
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1245 mL 10.6225 mL 21.245 mL 42.4899 mL 53.1124 mL
    5 mM 0.4249 mL 2.1245 mL 4.249 mL 8.498 mL 10.6225 mL
    10 mM 0.2124 mL 1.0622 mL 2.1245 mL 4.249 mL 5.3112 mL
    50 mM 0.0425 mL 0.2124 mL 0.4249 mL 0.8498 mL 1.0622 mL
    100 mM 0.0212 mL 0.1062 mL 0.2124 mL 0.4249 mL 0.5311 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Hederagonic acid References Information
    Citation [1]

    Chinese Journal of Natural Medicines, 2010 , 8 (6) :441-448

    Synthesis and Biological Evaluation of Arjunolic Acid, Bayogenin, Hederagonic Acid and 4-Epi-hederagonic Acid as Glycogen Phosphorylase Inhibitors[Reference: WebLink]
    To study glycogen phosphorylase inhibitory activity of natural pentacyclic triterpenes bearing 23-hydroxy or 24-hydroxy. METHODS: Arjunolic acid, bayogenin, Hederagonic acid and 4-epi-Hederagonic acid were synthesized from oleanolic acid as the starting material and biologically evaluated as glycogen phosphorylase inhibitors. RESULTS: Arjunolic acid, bayogenin, Hederagonic acid and 4-epi-Hederagonic acid were successfully semi-synthesized by multiple steps. The synthesis of arjunolic acid was via 11 steps in about 10% overall yield, and bayogenin via 14 steps in about 12% overall yield. Biological evaluation indicated that arjunolic acid, bayogenin, Hederagonic acid and 4-epi-Hederagonic acid showed moderate potency of glycogen phosphorylase inhibition with IC50 of 53-103 μmol·L?1. CONCLUSION: Arjunolic acid, bayogenin, Hederagonic acid and 4-epi-Hederagonic acid are gly-cogen phosphorylase inhibitors with moderate potency. Insert of 23-hydroxy or 24-hydroxy to oleanane skeleton has a tendency to be unfavorable to GP inhibition.