Hellebrigenol | CAS:508-79-2 | Manufacturer ChemFaces

Hellebrigenol

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Size /Price /Stock	10 mM * 1 mL in DMSO / $413 / In-stock
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Description:

Hellebrigenol shows cytotoxicity against HepG2 cells.

In vitro:

Anal Bioanal Chem. 2016 Apr;408(10):2485-95.

Metabolites profiling of 10 bufadienolides in human liver microsomes and their cytotoxicity variation in HepG2 cell.[Pubmed: 26869342 ]

Bufadienolides, a class of polyhydroxy steroids, exhibit significant antitumor activity.
METHODS AND RESULTS:
In this study, a total of 39 metabolites from 10 bufadienolides were detected and identified by ultrahigh-performance liquid chromatography (UHPLC) coupled with an LTQ Orbitrap mass spectrometer. The results showed that hydroxylation and dehydrogenation were the major metabolic pathways of bufadienolides in human liver microsomes (HLMs). CYP3A4 was found to be the major metabolic enzyme and CYP2D6 only mediated the dehydrogenation reaction. A systematic validated cytotoxicity evaluation method for bufadienolide metabolites at equal equivalents was established. Hellebrigenin (1), Hellebrigenol (2), arenobufagin (3), bufotalin (5), and bufalin (6) were selected to determine their cytotoxicity against HepG2 cells before and after incubation in HLMs. All the test samples were enriched by a validated solid-phase extraction (SPE) method.
CONCLUSIONS:
Although the cytotoxicities of metabolites were weaker than those of the parent compounds to different degrees, their effects were still strong.

Hellebrigenol Description

Source:	The glandular body of Bufo bufo gargarizans Cantor.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Hellebrigenol
Price:	$413 / 5mg
CAS No.:	508-79-2
Catalog No.:	CFN91021
Molecular Formula:	C₂₄H₃₄O₆
Molecular Weight:	418.52 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	The glandular body of Bufo bufo gargarizans Cantor.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Steroids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3894 mL	11.9469 mL	23.8937 mL	47.7874 mL	59.7343 mL
5 mM	0.4779 mL	2.3894 mL	4.7787 mL	9.5575 mL	11.9469 mL
10 mM	0.2389 mL	1.1947 mL	2.3894 mL	4.7787 mL	5.9734 mL
50 mM	0.0478 mL	0.2389 mL	0.4779 mL	0.9557 mL	1.1947 mL
100 mM	0.0239 mL	0.1195 mL	0.2389 mL	0.4779 mL	0.5973 mL

CFN90212	Gamabufotalin	465-11-2	402.52	C₂₄H₃₄O₅
CFN98578	Arenobufagin	464-74-4	416.51	C₂₄H₃₂O₆
CFN90151	Bufarenogin	17008-65-0	416.51	C₂₄H₃₂O₆
CFN91017	Pseudobufarenogin	17008-69-4	416.51	C₂₄H₃₂O₆
CFN98545	Bufotaline	471-95-4	444.56	C₂₆H₃₆O₆
CFN98543	Resibufogenin	465-39-4	384.51	C₂₄H₃₂O₄
CFN91013	Resibufagin	20987-24-0	398.49	C₂₄H₃₀O₅
CFN90579	Deacetylcinobufagin	4026-95-3	400.52	C₂₄H₃₂O₅
CFN98544	Cinobufagin	470-37-1	442.55	C₂₆H₃₄O₆
CFN91012	19-Oxocinobufagin	24512-59-2	456.53	C₂₆H₃₂O₇