(-)-Heraclenol | CAS:139079-42-8 | Manufacturer ChemFaces

(-)-Heraclenol

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $227.8 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

(-)-Heraclenol shows in vitro anti-plasmodial activity against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum.(-)-Heraclenol has moderate antibacterial and antifungal activities.

Targets:

Antifection

In vitro:

Current Science, 2011, 100(11):1706-1711.

Microbial transformation of (+)-heraclenin by Aspergillus niger and evaluation of its antiplasmodial and antimicrobial activities[Reference: WebLink]

METHODS AND RESULTS:
Microbial transformation of (+)-heraclenin (1) by Aspergillus niger was studied in growth media to assess its antiplasmodial and antimicrobial activities. It was transformed to (-)-Heraclenol (2) as the sole product in a stereospecific manner. The in vitro antiplasmodial activity of compounds 1 and 2 was tested with chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum. Further, the in vitro antibacterial activity of 1 and 2 against three Grampositive bacteria, Bacillus subtilis, Bacillus sphaericus and Staphylococcus aureus, and three Gram-negative bacteria, Pseudomonas aeruginosa, Escherichia coli and Chromobacterium violaceum was analysed using agar-plate diffusion assay. The same method was employed for the evaluation of antifungal activity against five pathogenic strains of fungi, A. niger, Rhizopus oryzae, Aspergillus flavus, Candida albicans and Saccharomyces cerevisiae.
CONCLUSIONS:
Both furanocoumarins 1 and 2 displayed significant levels of antiplasmodial and moderate levels of antimicrobial activities against the tested pathogenic strains. Compound 2 exhibited two-fold less potent antiplasmodial activity (IC50 = 6.0 μg/ml) than the parent compound 1 (IC50 = 2.5 μg/ml), whereas no difference was observed in the antimicrobial activity of both furanocoumarins. The oxirane ring was found to be beneficial in terms of antiplasmodial activity.

(-)-Heraclenol Description

Source:	The aerial parts of Incarvillea younghusbandii.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	(-)-Heraclenol
Price:	$268 / 5mg
CAS No.:	139079-42-8
Catalog No.:	CFN89405
Molecular Formula:	C₁₆H₁₆O₆
Molecular Weight:	304.29 g/mol
Purity:	>=98%
Type of Compound:	Coumarins
Physical Desc.:	Powder
Source:	The aerial parts of Incarvillea younghusbandii.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antibacterial Compound Library Antifungal Compound Library Antimalaric Compound Library Coumarins Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.2863 mL	16.4317 mL	32.8634 mL	65.7268 mL	82.1585 mL
5 mM	0.6573 mL	3.2863 mL	6.5727 mL	13.1454 mL	16.4317 mL
10 mM	0.3286 mL	1.6432 mL	3.2863 mL	6.5727 mL	8.2158 mL
50 mM	0.0657 mL	0.3286 mL	0.6573 mL	1.3145 mL	1.6432 mL
100 mM	0.0329 mL	0.1643 mL	0.3286 mL	0.6573 mL	0.8216 mL

CFN98758	Imperatorin	482-44-0	270.3	C₁₆H₁₄O₄
CFN98354	Heraclenin	2880-49-1	286.3	C₁₆H₁₄O₅
CFN98890	Isogosferol	53319-52-1	286.3	C₁₆H₁₄O₅
CFN98929	Isosaxalin	55481-86-2	322.7	C₁₆H₁₅ClO₅
CFN98402	Heraclenol	31575-93-6	304.3	C₁₆H₁₆O₆
CFN89405	(-)-Heraclenol	139079-42-8	304.29	C₁₆H₁₆O₆
CFN97112	Heraclenol acetonide	64790-68-7	344.4	C₁₉H₂₀O₆
CFN98410	Heraclenol 3'-O-beta-D-glucopyranoside	32207-10-6	466.4	C₂₂H₂₆O₁₁
CFN97243	Heraclenol 3'-O-[beta-D-apiofuranosyl-(1-6)-beta-D-glucopyranoside]	765316-44-7	598.6	C₂₇H₃₄O₁₅
CFN98247	Rivulobirin E	237407-59-9	590.6	C₃₂H₃₀O₁₁