|Source:||The herbs of Mangifera indica|
|Biological Activity or Inhibitors:|| 1. Homomangiferin shows antitumoural effects against MDA-MB-231 cells.
|Solvent:||DMSO, Pyridine, Methanol, Ethanol, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||2.2917 mL||11.4584 mL||22.9169 mL||45.8337 mL||57.2921 mL|
|5 mM||0.4583 mL||2.2917 mL||4.5834 mL||9.1667 mL||11.4584 mL|
|10 mM||0.2292 mL||1.1458 mL||2.2917 mL||4.5834 mL||5.7292 mL|
|50 mM||0.0458 mL||0.2292 mL||0.4583 mL||0.9167 mL||1.1458 mL|
|100 mM||0.0229 mL||0.1146 mL||0.2292 mL||0.4583 mL||0.5729 mL|
Food Funct. 2017 Oct 18;8(10):3610-3620.
|Selective antitumoural action of pressurized mango leaf extracts against minimally and highly invasive breast cancer.[Pubmed: 28891568]|
|Mango leaf tea has been traditionally used by different cultures to reduce inflammation in the body. There is evidence that chronic inflammation increases the risk of cancer. This study investigates the antitumoural effects of pressurized mango leaf extracts on minimally (MCF7) and highly invasive (MDA-MB-231) breast cancer cells as well as on non-tumourigenic cells (MCF10). Extracts showed protective properties against oxidation and cytotoxic effects against breast cancer cell lines, causing minor damage to non-carcinogenic cells. Nonetheless, some selective activity, depending on hormone receptor status, was observed. This was possibly related to the presence of minor compounds. Extracts with high levels of gallotannins showed cytotoxic action against MCF7 cells, while those which had methyl gallate and Homomangiferin as common components were more effective against MDA-MB-231 cells. Therefore, the cytotoxic effect of mango leaf extracts might be attributed to the synergistic effect of different polyphenols and not just to mangiferin on its own as the predominant compound in mango leaves.|