Hypaconine | CAS:63238-68-6 | Manufacturer ChemFaces

Hypaconine

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Size /Price /Stock	10 mM * 1 mL in DMSO / $239.2 / In-stock
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Description:

Hypaconine exhibits strong cardiac activity.

In vitro:

Nat Prod Commun. 2012 Jun;7(6):713-20.

Structure-cardiac activity relationship of C19-diterpenoid alkaloids.[Pubmed: 22816290]

Thirty three C19-diterpenoid alkaloids, twenty-two prepared from known C19-diterpenoid alkaloids and eleven isolated from Aconitum and Delphinium spp. were evaluated for their cardiac activity in the isolated bullfrog heart assay.
METHODS AND RESULTS:
Among them, eleven compounds exhibited cardiac activity, with average rate of amplitude increase in the range of 16-118%. Compound 7, mesaconine (17), Hypaconine (25), and beiwutinine (26) exhibited strong cardiac activities relative to the reference drug.
CONCLUSIONS:
The structure-activity relationship data acquired indicated that an alpha-hydroxyl group at C-15, a hydroxyl group at C-8, an alpha-methoxyl or hydroxyl group at C-1, and a secondary amine or N-methyl group in ring A are important structure features necessary for the cardiac activities of the aconitine-type C19-diterpenoid alkaloids without any ester groups. In addition, an alpha-hydroxyl group at C-3 is also helpful for the cardiac activity of these alkaloids.

Hypaconine Description

Source:	The roots of Aconitum kusnezoffii Reichb.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Hypaconine
Price:	$368 / 10mg
CAS No.:	63238-68-6
Catalog No.:	CFN93039
Molecular Formula:	C₂₄H₃₉NO₈
Molecular Weight:	469.57 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The roots of Aconitum kusnezoffii Reichb.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1296 mL	10.648 mL	21.2961 mL	42.5922 mL	53.2402 mL
5 mM	0.4259 mL	2.1296 mL	4.2592 mL	8.5184 mL	10.648 mL
10 mM	0.213 mL	1.0648 mL	2.1296 mL	4.2592 mL	5.324 mL
50 mM	0.0426 mL	0.213 mL	0.4259 mL	0.8518 mL	1.0648 mL
100 mM	0.0213 mL	0.1065 mL	0.213 mL	0.4259 mL	0.5324 mL

CFN93039	Hypaconine	63238-68-6	469.57	C₂₄H₃₉NO₈
CFN93137	Mesaconine	6792-09-2	485.57	C₂₄H₃₉NO₉
CFN90688	Benzoylhypacoitine	63238-66-4	573.29	C₃₁H₄₃NO₉
CFN98575	Benzoylmesaconine	63238-67-5	589.68	C₃₁H₄₃NO₁₀
CFN98576	Benzoylmesaconine hydrochloride	126266-38-4	626.2	C₃₁H₄₄ClNO₁₀
CFN99200	Hypaconitine	6900-87-4	615.71	C₃₃H₄₅NO₁₀
CFN99199	Mesaconitine	2752-64-9	631.71	C₃₃H₄₅NO₁₁