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Isoretronecanol
Isoretronecanol
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Isoretronecanol
Price:
CAS No.: 526-63-6
Catalog No.: CFN00281
Molecular Formula: C8H15NO
Molecular Weight: 141.21 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Oil
Source:
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Standard reference
Isoretronecanol Description
Source:
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 7.0817 mL 35.4083 mL 70.8165 mL 141.633 mL 177.0413 mL
5 mM 1.4163 mL 7.0817 mL 14.1633 mL 28.3266 mL 35.4083 mL
10 mM 0.7082 mL 3.5408 mL 7.0817 mL 14.1633 mL 17.7041 mL
50 mM 0.1416 mL 0.7082 mL 1.4163 mL 2.8327 mL 3.5408 mL
100 mM 0.0708 mL 0.3541 mL 0.7082 mL 1.4163 mL 1.7704 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Tetrahedron,2014,70(2):204–11.
Asymmetric syntheses of (−)-isoretronecanol and (−)-trachelantamidine[Reference: WebLink]
Short and concise total asymmetric syntheses of (−)-Isoretronecanol and (−)-trachelantamidine are reported.
METHODS AND RESULTS:
Oxidative cleavage of tert-butyl (S,S,S,Z)-7-[N-benzyl-N-(α-methylbenzyl)amino]cyclohept-3-ene-1-carboxylate, followed by hydrogenolysis promoted in situ cyclisation/reduction, which provided rapid access to the bicyclic core within (−)-Isoretronecanol. Analogous treatment of the C(1)-epimer gave (−)-trachelantamidine.
CONCLUSIONS:
Overall, the syntheses of (−)-Isoretronecanol and (−)-trachelantamidine were completed in eight and seven steps and 20 and 9.5% yield, respectively, from commercially available starting materials.
Tetrahedron Letters,2005,46(15);2691-3.
The stereoselective addition of titanium(IV) enolates of 1,3-oxazolidin-2-one and 1,3-thiazolidine-2-thione to cyclic N-acyliminium ion. The total synthesis of (+)-isoretronecanol[Reference: WebLink]

METHODS AND RESULTS:
(+)-Isoretronecanol (1) has been prepared in four steps and 36% overall yield via the diastereoselective addition of the titanium(IV) enolate derived from N-4-chlorobutyryl-1,3-thiazolidine-2-thione (3) to N-Boc-2-methoxypyrrolidine (5), which afforded 2-substituted pyrrolidine 7 in 84% yield (8:1 diastereoisomeric ratio), followed by reductive recovery of the chiral auxiliary and cyclization.
Tetrahedron: Asymmetry,2011,22(6):662–668.
A common approach to pyrrolizidine and indolizidine alkaloids; formal synthesis of (−)-isoretronecanol, (−)-trachelanthamidine and an approach to the synthesis of (−)-5-epitashiromine and (−)-tashiromine[Reference: WebLink]

METHODS AND RESULTS:
A common and short stereoselective route is described for the formal synthesis of pyrrolizidine alkaloids, (−)-Isoretronecanol and (−)-trachelanthamidine. An approach to the synthesis of indolizidine alkaloids (−)-5-epitashiromine and (−)-tashiromine utilizing ring closing metathesis is also described starting from commercially available and inexpensive l-proline.
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