Science | Nature | Cell | View More
Natural Products
Junicedric acid
Junicedric acid
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Junicedric acid
Price:
CAS No.: 41787-69-3
Catalog No.: CFN89382
Molecular Formula: C20H32O4
Molecular Weight: 336.46 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The fronds of Dicranopteris linearis or D. ampla.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • National Cancer Center Research... (Japan)
  • University of Queensland (Australia)
  • Universidad de Antioquia (Colombia)
  • University of Liège (Belgium)
  • Leibniz-Institut für Pflanzenb... (Germany)
  • Worcester Polytechnic Institute (USA)
  • Mahatma Gandhi University (India)
  • Cancer Research Initatives Foun... (Malaysia)
  • Imperial College London (United Kingdom)
  • Universidade Federal de Santa C... (Brazil)
  • University of Mysore (India)
  • More...
Package
Featured Products
Brucine sulfate

Catalog No: CFN90316
CAS No: 4845-99-2
Price: $50/20mg
Tricin

Catalog No: CFN98841
CAS No: 520-32-1
Price: $258/10mg
Aloin B

Catalog No: CFN90434
CAS No: 28371-16-6
Price: $138/20mg
Acetyleugenol

Catalog No: CFN70222
CAS No: 93-28-7
Price: $30/20mg
(-)-Asarinin

Catalog No: CFN90144
CAS No: 133-04-0
Price: $128/20mg
Berbamine

Catalog No: CFN98727
CAS No: 478-61-5
Price: $50/20mg
Celastrol

Catalog No: CFN99198
CAS No: 34157-83-0
Price: $40/20mg
Rebaudioside C

Catalog No: CFN90258
CAS No: 63550-99-2
Price: $100/20mg
10-Shogaol

Catalog No: CFN92300
CAS No: 36752-54-2
Price: $138/20mg
20(R)-Ginsenoside Rg3

Catalog No: CFN98170
CAS No: 38243-03-7
Price: $60/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Junicedric acid has gastroprotective effects.
In vitro:
Molecules. 2011 Oct 13;16(10):8614-28.
Synthesis and pharmacological activity of diterpenylnaphthoquinone derivatives.[Pubmed: 21996716]

METHODS AND RESULTS:
New diterpenylquinones, combining a diterpene diacid and a naphthoquinone, were prepared from Junicedric acid and lapachol. The new derivatives were assessed as gastroprotective agents by the HCl-EtOH-induced gastric lesions model in mice as well as for basal cytotoxicity on the following human cell lines: Normal lung fibroblasts (MRC-5), gastric epithelial adenocarcinoma (AGS), and hepatocellular carcinoma (Hep G2).
CONCLUSIONS:
Several of the new compounds were significantly active as antiulcer agents and showed selective cytotoxicity against AGS cells.
In vivo:
Molecules. 2010 Oct 21;15(10):7378-94.
Synthesis, gastroprotective effect and cytotoxicity of new amino acid diterpene monoamides and diamides.[Pubmed: 20966879 ]
Following our studies on the gastroprotective effect and cytotoxicity of terpene derivatives, new amides were prepared from the diterpene 8(17)-labden-15,19-dioic acid (Junicedric acid) and its 8(9)-en isomer with C-protected amino acids (amino acid esters).
METHODS AND RESULTS:
The new compounds were evaluated for their gastroprotective effect in the ethanol/HCl-induced gastric lesions model in mice, as well as for cytotoxicity using the following human cell lines: normal lung fibroblasts (MRC-5), gastric adenocarcinoma cells (AGS) and liver hepatocellular carcinoma (Hep G2). A dose-response experiment showed that at 25 mg/kg the C-15 leucyl and C-15,19-dileucylester amides of Junicedric acid reduced gastric lesions by about 65.6 and 49.6%, respectively, with an effect comparable to lansoprazole at 20 mg/kg (79.3% lesion reduction). The comparison of the gastroprotective effect of 18 new amino acid ester amides was carried out at a single oral dose of 25 mg/kg. Several compounds presented a strong gastroprotective effect, reducing gastric lesions in the 70.9-87.8% range.
CONCLUSIONS:
The diprolyl derivative of Junicedric acid, the most active product of this study (87.8% lesion reduction at 25 mg/kg) presented a cytotoxicity value comparable with that of the reference compound lansoprazole. The structure-activity relationships are discussed.
Junicedric acid Description
Source: The fronds of Dicranopteris linearis or D. ampla.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Maculosidin

Catalog No: CFN95126
CAS No: 522-19-0
Price: $413/5mg
Biatractylolide

Catalog No: CFN95205
CAS No: 182426-37-5
Price: $268/10mg
N-trans-caffeoyloctopamine

Catalog No: CFN95264
CAS No: 1378868-10-0
Price: $413/5mg
7-Oxodehydroabietic acid

Catalog No: CFN95411
CAS No: 18684-55-4
Price: $318/5mg
Tumulosic acid

Catalog No: CFN95399
CAS No: 508-24-7
Price: $368/5mg
Oxytroflavoside D

Catalog No: CFN95491
CAS No: 1391144-83-4
Price: $318/10mg
1-(3',5'-dimethoxy)phenyl-2-[4''-O...

Catalog No: CFN95285
CAS No: 1338076-61-1
Price: $413/5mg
Pterodonoic acid

Catalog No: CFN95183
CAS No: 62458-42-8
Price: $413/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9721 mL 14.8606 mL 29.7212 mL 59.4424 mL 74.303 mL
5 mM 0.5944 mL 2.9721 mL 5.9442 mL 11.8885 mL 14.8606 mL
10 mM 0.2972 mL 1.4861 mL 2.9721 mL 5.9442 mL 7.4303 mL
50 mM 0.0594 mL 0.2972 mL 0.5944 mL 1.1888 mL 1.4861 mL
100 mM 0.0297 mL 0.1486 mL 0.2972 mL 0.5944 mL 0.743 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Helvetica Chimica Acta, 2010, 91(5):856-861.
Terpenoids from Two Dicranopteris Species.[Reference: WebLink]

METHODS AND RESULTS:
Two new compounds, (6S,13S)-6-{[β-D-glucopyranosyl-(1→4)-α-L-rhamnopyranosyl]oxy}cleroda-3,14-dien-13-ol (1) and kadsuric acid 3-methyl ester (2), together with nine known compounds, (6S,13E)-6-{[β-D-glucopyranosyl-(1→4)-α-L-rhamnopyranosyl]oxy}cleroda-3,13-dien-15-ol (3), (6S,13S)-6-[6-O-acetyl-β-D-glucopyranosyl-(1→4)-α-L-rhamnopyranosyl]oxy}-13-{[α-L-rhamnopyranosyl-(1→4)-β-D-fucopyranosyl]oxy}cleroda-3,14-diene (4), (6S,13S)-6-{[6-O-β-D-glucopyranosyl-(1→4)-α-L-rhamnopyranosyl]oxy}-13-{[α-L-rhamnopyranosyl-(1→4)-β-D-fucopyranosyl]oxy}cleroda-3,14-diene (5), 15-hydroxydehydroabietic acid (6), 15-hydroxylabd-8(17)-en-19-oic acid (7), Junicedric acid (8), (4β)-kaur-16-en-18-oic acid (9), (4β)-16-hydroxykauran-18-oic acid (10), and (4β,16β)-16-hydroxykauran-18-oic acid (11) were isolated from the fronds of Dicranopteris linearis or D. ampla.
CONCLUSIONS:
Their structures were established by extensive 1D- and 2D-NMR spectroscopy. Compounds 1 and 3–8 showed no anti-HIV activities.
Brucine sulfate

Catalog No: CFN90316
CAS No: 4845-99-2
Price: $50/20mg
Tricin

Catalog No: CFN98841
CAS No: 520-32-1
Price: $258/10mg
Aloin B

Catalog No: CFN90434
CAS No: 28371-16-6
Price: $138/20mg
Acetyleugenol

Catalog No: CFN70222
CAS No: 93-28-7
Price: $30/20mg
(-)-Asarinin

Catalog No: CFN90144
CAS No: 133-04-0
Price: $128/20mg
Berbamine

Catalog No: CFN98727
CAS No: 478-61-5
Price: $50/20mg
Celastrol

Catalog No: CFN99198
CAS No: 34157-83-0
Price: $40/20mg
Rebaudioside C

Catalog No: CFN90258
CAS No: 63550-99-2
Price: $100/20mg
10-Shogaol

Catalog No: CFN92300
CAS No: 36752-54-2
Price: $138/20mg
20(R)-Ginsenoside Rg3

Catalog No: CFN98170
CAS No: 38243-03-7
Price: $60/20mg
Tags: buy Junicedric acid | Junicedric acid supplier | purchase Junicedric acid | Junicedric acid cost | Junicedric acid manufacturer | order Junicedric acid | Junicedric acid distributor
y>