Kaempferol 3-O-beta-sophoroside | CAS:19895-95-5

Kaempferol 3-O-beta-sophoroside

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Description:

Kaempferol 3-O-beta-sophoroside has antibacterial and antiviral activities.

Targets:

Antifection

In vitro:

Inflamm Res . 2012 Mar;61(3):217-24.

Anti-inflammatory effects of kaempferol-3-O-sophoroside in human endothelial cells[Pubmed: 22113342]

Abstract Background: Kaempferol-3-O-sophoroside (KPOS) was isolated from the leaves of cultivated mountain ginseng. Kaempferol (KP) has antitumor, anti-oxidative, anti-allergic and antidiabetic activities but the barrier protective effects and underlying mechanism are not fully identified. In this study, we attempted to determine whether pretreatment with KPOS induced significant barrier protective activities in lipopolysaccharide (LPS)-stimulated human umbilical vein endothelial cells (HUVECs). Methods: The anti-inflammatory activities of KPOS were determined by measuring solute flux, neutrophil adhesion and migration and activation of pro-inflammatory proteins in LPS-activated HUVECs. Results: We found that KPOS inhibited LPS-induced barrier disruption, expression of cell adhesion molecules, neutrophil adhesion and transendothelial migration of neutrophils to HUVECs. Further studies revealed that KPOS suppressed the production of tumor necrosis factor-α (TNF-α) and activation of nuclear factor-κB (NF-κB) by LPS, and that anti-inflammatory activities of KPOS were better than those of KP. Conclusion: Collectively, these results suggest that KPOS possesses barrier integrity activity, inhibitory activity on cell adhesion and migration to endothelial cells by blocking the activation of NF-κB expression and production of TNF-α, thereby endorsing its usefulness as therapy for vascular inflammatory diseases.

Kaempferol 3-O-beta-sophoroside Description

Source:	The herbs of Carthamus lanatus L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Phytochemistry. 2006 Jan;67(2):191-201.

Flavonols and an indole alkaloid skeleton bearing identical acylated glycosidic groups from yellow petals of Papaver nudicaule.[Pubmed: 16376394]

From yellow petals of Iceland poppy, besides the known flavonoid gossypitrin, seven kaempferol derivatives were isolated.
METHODS AND RESULTS:
In addition to Kaempferol 3-O-beta-sophoroside and Kaempferol 3-O-beta-sophoroside-7-O-beta-glucoside, known from other plants, the mono- and dimalonyl conjugates of the latter were identified by MS and NMR spectroscopy. Structure analyses of a set of co-occurring pigments, the nudicaulins, revealed that they have the identical acylated glycoside moieties attached to a pentacyclic indole alkaloid skeleton for which the structure of 19-(4-hydroxyphenyl)-10H-1,10-ethenochromeno[2,3-b]indole-6,8,18-triol was deduced from MS and NMR as well as chemical and chiroptical methods.

Product Name	Kaempferol 3-O-beta-sophoroside
Price:	$268 / 20mg
CAS No.:	19895-95-5
Catalog No.:	CFN92372
Molecular Formula:	C₂₇H₃₀O₁₆
Molecular Weight:	610.5 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Yellow powder
Source:	The herbs of Carthamus lanatus L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Analgesia Compound Library Flavonoids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.638 mL	8.19 mL	16.38 mL	32.76 mL	40.95 mL
5 mM	0.3276 mL	1.638 mL	3.276 mL	6.552 mL	8.19 mL
10 mM	0.1638 mL	0.819 mL	1.638 mL	3.276 mL	4.095 mL
50 mM	0.0328 mL	0.1638 mL	0.3276 mL	0.6552 mL	0.819 mL
100 mM	0.0164 mL	0.0819 mL	0.1638 mL	0.3276 mL	0.4095 mL

CFN93560	Camelliaside B	131573-90-5	726.6	C₃₂H₃₈O₁₉
CFN90819	Mauritianin	109008-28-8	740.7	C₃₃H₄₀O₁₉
CFN93559	Camelliaside A	135095-52-2	756.66	C₃₃H₄₀O₂₀
CFN91161	Plantanone B	55780-30-8	756.7	C₃₃H₄₀O₂₀
CFN96532	Kaempferol 3-O-rhamninoside	83170-31-4	740.66	C₃₃H₄₀O₁₉
CFN95134	Rhamnocitrin 3-glucoside	41545-37-3	462.4	C₂₂H₂₂O₁₁
CFN95474	Rhamnocitrin 3-galactoside	99878-05-4	462.4	C₂₂H₂₂O₁₁
CFN95491	Oxytroflavoside D	1391144-83-4	606.5	C₂₈H₃₀O₁₅
CFN96538	Catharticin	39723-40-5	754.69	C₃₄H₄₂O₁₉
CFN95489	Oxytroflavoside F	1391144-85-6	608.6	C₂₈H₃₂O₁₅