ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
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More articles cited ChemFaces products.
Am J Chin Med.2015 Jul 30:1-22.Int J Mol Sci. 2014 May 13;15(5):8443-57.Anal Bioanal Chem.2018 Feb;Evid Based Complement Alternat Med. 2017Phytomedicine.2018 Jan 1;
Acta Physiologiae Plantarum.2014 10.Phytomedicine2015 August 14J of L. Chroma. & Related Tech2017 Apr 21;FEBS Lett.2015 Jan 2;589(1):182-7. Chemistry of Natural CompoundsJan. 2018;
Sci Rep. Jan. 2018Evid Based Complement Alternat Med.2017:7383104Molecules 2016, 21(6)2016 Jun 22;21(6). Oncotarget. 2017 Dec 23;
Our products had been exported to the following research institutions and universities, And still growing.
Weizmann Institute of Science (Israel)Universidad Miguel Hernández (Spain)Funda??o Universitária de Desen... (Brazil)Gyeongsang National University (Korea)
University of Padjajaran (Indonesia)University of Mysore (India)University of Madras (India)Nicolaus Copernicus Uniwersity (Poland)
Kazusa DNA Research Institute (Japan)Centralised Purchases Unit (CPU)... (India)Periyar University (India)
||1. Kihadanin B can repress the adipogenesis by decreasing lipid accumulation through the suppression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes.|
||Akt | PPAR|
Kihadanin B Description
||The barks of Phellodendron amurense
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi: 10.1016/j.phymed.2017.12.030.PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Kihadanin B References Information
J. Agric. Food Chem., 2016, 64 (51): 9607-15.
|A limonoid kihadanin B from immature Citrus unshiu peels suppresses adipogenesis through repression of Akt-FOXO1-PPARγ axis in adipocytes[Reference: WebLink]|
|Kihadanin B was purified from the peels of immature Citrus unshiu by HPLC, and its chemical structure was determined by NMR and mass spectrometry. Kihadanin B reduced the lipid accumulation with the reduction of the expression levels of the adipogenic and lipogenic genes, but did not affect to lipolysis in adipocytes. Phosphorylation levels of Akt and a forkhead transcriptional factor, FOXO1, a repressor of PPARγ were lowered by Kihadanin B. Furthermore, Kihadanin B increased the binding level of FOXO1 to the PPARγ gene promoter in adipocytes. These results indicate that a Citrus limonoid Kihadanin B repressed the adipogenesis by decreasing lipid accumulation through the suppression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes.