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    Kuwanon A
    Information
    CAS No. 62949-77-3 Price $268 / 5mg
    Catalog No.CFN90834Purity>=98%
    Molecular Weight420.5Type of CompoundFlavonoids
    FormulaC25H24O6Physical DescriptionYellow powder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Kuwanon A Description
    Source: The root barks of Morus alba L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

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    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

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    Phytomedicine. 2018 Feb 1;40:37-47.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3781 mL 11.8906 mL 23.7812 mL 47.5624 mL 59.453 mL
    5 mM 0.4756 mL 2.3781 mL 4.7562 mL 9.5125 mL 11.8906 mL
    10 mM 0.2378 mL 1.1891 mL 2.3781 mL 4.7562 mL 5.9453 mL
    50 mM 0.0476 mL 0.2378 mL 0.4756 mL 0.9512 mL 1.1891 mL
    100 mM 0.0238 mL 0.1189 mL 0.2378 mL 0.4756 mL 0.5945 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Chemical & Pharmaceutical Bulletin, 2008 , 26 (5) :1453-8.
    Studies on the constituents of the cultivated mulberry tree. III. Isolation of four new flavones, kuwanon A, B, C and oxydihydromorusin from the root bark of Morus alba L[Reference: WebLink]
    The structures of four new flavone derivatives, Kuwanon A, kuwanon B, kuwanon C and oxydihydromorusin were isolated from the benzene extract of the root bark of the cultivated mulberry tree (a variety of Morus alba L.), and were shown to be I, II, III and IV, respectively, on the basis of spectroscopic and chemical evidences.
    CONCLUSIONS:
    Photooxidative cyclization did not occur with I but with II leading to the formation of a hydroperoxide possessing a dihydrooxepin ring. III was cyclized on photooxidation as II and was converted to morusin (V) by treating with DDQ. On hydration with methanolic hydrochloric acid, V was converted to IV.