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    Lithospermoside
    Information
    CAS No. 63492-69-3 Price $100 / 20mg
    Catalog No.CFN99780Purity>=98%
    Molecular Weight329.30Type of CompoundMiscellaneous
    FormulaC14H19NO8Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Lithospermoside has anti-oxidant,and anti-tumor promoting activities.
    In vitro:
    Nat Prod Res. 2015 Jan 2:1-4.
    Cytotoxic flavonoids and other constituents from the stem bark of Ochna schweinfurthiana.[Pubmed: 25553908]
    Seven flavonoids, hemerocallone (1), 6,7-dimethoxy-3',4'-dimethoxyisoflavone (2), amentoflavone (4), agathisflavone (6), cupressuflavone (8), robustaflavone (9) and epicatechin (10), together with three other compounds, Lithospermoside (3), β-D-fructofuranosyl-α-D-glucopyranoside (5) and 3β-O-D-glucopyranosyl-β-stigmasterol (7), were isolated from the ethyl acetate extract of the stem bark of Ochna schweinfurthiana F. Hoffm.
    METHODS AND RESULTS:
    All the compounds were characterised by spectroscopic and mass spectrometric methods, and by comparison with literature data. Cytotoxicity of the extracts and compounds against cervical adenocarcinoma (HeLa) cells was evaluated by MTT assay.
    CONCLUSIONS:
    Compounds 4 and 6 exhibited good cytotoxic activity, with IC50 values of 20.7 and 10.0 μM, respectively.
    Cancer Lett. 1999 Aug 23;143(1):5-13.
    Anti-tumor promoting activity of polyphenols from Cowania mexicana and Coleogyne ramosissima.[Pubmed: 10465331]

    METHODS AND RESULTS:
    Chemical investigation on polyphenol-rich fractions of Cowania mexicana and Coleogyne ramosissima (Rosaceae) which showed significant inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), has led to the characterization of 10 compounds including C-glucosidic ellagitannin monomers and dimers from the former plant, and 17 polyphenols including flavonoid glycosides from the latter. The effects of individual components and their analogues with related structures on the TPA-induced EBV-EA activation were then evaluated. Among the compounds isolated from C. mexicana, two C-glucosidic ellagitannins, alienanin B and stenophyllanin A and a nitrile glucoside (Lithospermoside), and among the constituents from C. ramosissima, two flavonoid glycosides, isorhamnetin 3-0-beta-D-glucoside and narcissin were revealed to possess strong inhibitory effects on EVB-EA activation, the potencies of which were either comparable to or stronger than that of a green tea polyphenol, (-)-epigallocatechin gallate.
    CONCLUSIONS:
    These polyphenols except for nitrile glucoside, which was not tested owing to an insufficient amount, were also found to exhibit anti-tumor promoting activity in two-stage mouse skin carcinogenesis using 7,12-dimethylbenz[a]anthracene (DMBA) and TPA.
    Lithospermoside Description
    Source: The roots of Lithospermum officinale.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

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    PMID: 29328914

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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0367 mL 15.1837 mL 30.3674 mL 60.7349 mL 75.9186 mL
    5 mM 0.6073 mL 3.0367 mL 6.0735 mL 12.147 mL 15.1837 mL
    10 mM 0.3037 mL 1.5184 mL 3.0367 mL 6.0735 mL 7.5919 mL
    50 mM 0.0607 mL 0.3037 mL 0.6073 mL 1.2147 mL 1.5184 mL
    100 mM 0.0304 mL 0.1518 mL 0.3037 mL 0.6073 mL 0.7592 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    J Nat Prod. 2006 Aug;69(8):1206-8.
    Minor biflavonoids from Lophira alata leaves.[Pubmed: 16933877]
    The leaves of the Cameroonian medicinal plant Lophira alata afforded two new biflavonoids, lophirone L (1) and lophirone M (2), and the known luteolin and Lithospermoside. Both biflavonoids were obtained in small quantities, and their structures show some new and unusual biflavonoid diversity.