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Lochnericine
Lochnericine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Lochnericine
Price:
CAS No.: 72058-36-7
Catalog No.: CFN97697
Molecular Formula: C21H24N2O3
Molecular Weight: 352.43 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Catharanthus roseus (L.)G.Don
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Description: Lochnericine (LOC) is a component of Voacanga africana, which is a type of traditional medical food in Africa widely used for treating diseases.
Lochnericine Description
Source: The herbs of Catharanthus roseus (L.)G.Don
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8374 mL 14.1872 mL 28.3744 mL 56.7489 mL 70.9361 mL
5 mM 0.5675 mL 2.8374 mL 5.6749 mL 11.3498 mL 14.1872 mL
10 mM 0.2837 mL 1.4187 mL 2.8374 mL 5.6749 mL 7.0936 mL
50 mM 0.0567 mL 0.2837 mL 0.5675 mL 1.135 mL 1.4187 mL
100 mM 0.0284 mL 0.1419 mL 0.2837 mL 0.5675 mL 0.7094 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Luminescence. 2015 Mar;30(2):240-6.
Spectroscopy and docking simulations of the interaction between lochnericine and bovine serum albumin.[Pubmed: 24942935]
Lochnericine (LOC) is a component of Voacanga africana, which is a type of traditional medical food in Africa widely used for treating diseases.
METHODS AND RESULTS:
In this article, the interaction between Lochnericine and bovine serum albumin (BSA) was studied by fluorescence spectroscopy. Furthermore, Fourier transform infrared (FTIR), Raman and circular dichroism (CD) were used to investigate the structural changes of BSA. The experimental results consistently indicated that Lochnericine changed the secondary structure of BSA. Three structure-similar components were used to study the interference experiments.
CONCLUSIONS:
The molecular modeling results showed that Lochnericine could bind within not only sites I and II, but also bind the cavity of subdomain IB.
CFN97509Leuconolam93710-27-1326.4 C19H22N2O3
CFN97697Lochnericine72058-36-7352.43C21H24N2O3
CFN98678Tabersonine4429-63-4336.4 C21H24N2O2
CFN98353Meloscandonine28645-27-4320.4 C20H20N2O2
CFN9930410-Hydroxyscandine119188-47-5366.4 C21H22N2O4
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