| Pharmazie. 1996 Oct;51(10):765-8. |
| In vitro anti-complementary activity of flavonoids from olive (Olea europaea L.) leaves.[Pubmed: 8941947] |
METHODS AND RESULTS:
From extracts of olive (Olea europaea L., Oleaceae) leaves showing anti-complementary activity, the flavonoids apigenin, apigenin-4'-O-rhamnosylglucoside, apigenin-7-O-glucoside, luteolin, Luteolin-4'-O-glucoside, luteolin-7-O-glucoside, chrysoeriol, chrysoeriol-7-O-glucoside and quercetin-3-O-rhamnoside were isolated.
CONCLUSIONS:
Major isolated constituents strongly inhibited the classical pathway of the complement system. |
| Journal of the Korean Society of Food Science & Nutrition, 2004, 33(9). |
| Isolation of Antioxidant and Antibrowning Substance from Chionanthus retusa Leaves[Reference: WebLink] |
METHODS AND RESULTS:
This study was performed to examine in vitro antioxidative activities such as DPPH radical scavenging activity, reducing power and tyrosinase inhibitory effect of various solvent fractions from Chionanthus retusa leaves.
Ethyl acetate fraction showed potent antioxidative activity and tyrosinase inhibitory effect. The active compound was isolated from the butanol fraction by silica gel column chromatography and MPLC. The isolated compound was Luteolin-4'-O-glucoside determined by , -NMR and 2D NMR. Compared with several antioxidant compounds, Luteolin-4'-O-glucoside exhibited effective DPPH radical scavenging activity and reducing power in a concentration dependent manner. Bioassay with pure Luteolin-4'-O-glucoside showed a dose-independent inhibitory effect on L-DOPA oxidation by mushroom tyrosinase and its values were established as 23.2 .
CONCLUSIONS:
Therefore, we may suggest that Luteolin-4'-O-glucoside can be used as a food additive possessing the potent antioxidative activity and skin-whitening cosmetic material. |
| J Ethnopharmacol. 2000 Jun;70(3):213-7. |
| Studies on anti-complementary activity of extracts and isolated flavones from Ligustrum vulgare and Phillyrea latifolia leaves (Oleaceae).[Pubmed: 10837985] |
METHODS AND RESULTS:
Polar fractions and flavones isolated from methanolic extracts of the leaves of Ligustrum vulgare and Phillyrea latifolia (Oleaceae), whose popular use as an anti-inflammatory is well-known in Mediterranean historical medicine and ethnobotany, showed significant in vitro complement inhibiting effect on the classical pathway of the complement system.
CONCLUSIONS:
Among the isolated flavonoidic structures, apigenin-7-O-glucoside, apigenin-7-O-rutinoside, Luteolin-4'-O-glucoside, luteolin-7-O-glucoside and ligustroflavone presented remarkable activity. |
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)