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Lydicamycin
Lydicamycin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Lydicamycin
Price:
CAS No.: 133352-27-9
Catalog No.: CFN00123
Molecular Formula: C47H74N4O10
Molecular Weight: 855.12 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: From Streptomyces aureofaciens
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Lydicamycin is active against Gram-positive bacteria and a certain yeast.
Targets: Antifection
In vitro:
J Antibiot (Tokyo). 1991 Mar;44(3):282-7.
Lydicamycin, a new antibiotic of a novel skeletal type. I. Taxonomy, fermentation, isolation and biological activity.[Pubmed: 2026553]

METHODS AND RESULTS:
A novel antibiotic, designated Lydicamycin, was isolated from the fermentation broth of an actinomycete strain identified as Streptomyces lydicus. Lydicamycin was active against Gram-positive bacteria and a certain yeast, but inactive against Gram-negative bacteria.
J Antibiot (Tokyo). 2002 Oct;55(10):873-80.
TPU-0037-A, B, C and D, novel lydicamycin congeners with anti-MRSA activity from Streptomyces platensis TP-A0598.[Pubmed: 12523820]

METHODS AND RESULTS:
In screening for anti-MRSA antibiotics, novel Lydicamycin congeners, TPU-0037-A, B, C and D, were isolated from a culture broth of an actinomycete strain. The producing strain, TP-A0598, was isolated from a seawater sample collected in Toyama Bay, Japan, and identified as Streptomyces platensis based on taxonomic characteristics. TPU-0037-A, B, C and D were purified by HP-20 resin, ODS column chromatographies and preparative HPLC, consecutively, and their structures were determined to be 30-demethylLydicamycin, 14,15-dehydro-8-deoxyLydicamycin, 30-demethyl-8-deoxyLydicamycin and 8-deoxyLydicamycin, respectively, by NMR and MS analyses.
CONCLUSIONS:
The new congeners showed antibiotic activity against gram-positive bacteria including MRSA with the MIC of 1.56 to approximately 12.5 microg/ml.
Lydicamycin Description
Source: From Streptomyces aureofaciens
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
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IF=36.216(2019)

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doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.1694 mL 5.8471 mL 11.6943 mL 23.3885 mL 29.2357 mL
5 mM 0.2339 mL 1.1694 mL 2.3389 mL 4.6777 mL 5.8471 mL
10 mM 0.1169 mL 0.5847 mL 1.1694 mL 2.3389 mL 2.9236 mL
50 mM 0.0234 mL 0.1169 mL 0.2339 mL 0.4678 mL 0.5847 mL
100 mM 0.0117 mL 0.0585 mL 0.1169 mL 0.2339 mL 0.2924 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Antibiot (Tokyo). 1991 Mar;44(3):288-92.
Lydicamycin, a new antibiotic of a novel skeletal type. II. Physico-chemical properties and structure elucidation.[Pubmed: 2026554 ]

METHODS AND RESULTS:
The structure of a new antibiotic designated Lydicamycin was elucidated as shown in Fig. 1 by NMR spectral analysis including a variety of 2D techniques. Lydicamycin possesses a novel skeleton containing tetramic acid and amidinopyrrolidine moieties.
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CAS No: 20736-09-8
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Tanshinone IIB

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CAS No: 17397-93-2
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Senecionine N-oxide

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CAS No: 13268-67-2
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Biorobin

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Niga-ichigoside F1

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