Maackiaflavanone | CAS:156162-10-6 | Manufacturer ChemFaces

Maackiaflavanone

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Description:

Maackiaflavanone B shows cytotoxic activity with IC(50) value of 7.8 microM against human cancer cell line A375S2.

In vitro:

Chem Pharm Bull (Tokyo). 2009 Mar;57(3):302-6.

Cytotoxic prenylated flavonoids from the stem bark of Maackia amurensis.[Pubmed: 19252325]

METHODS AND RESULTS:
A new prenylated isoflavan, iconisoflavan (1), and a new prenylated isoflav-3-ene, iconisoflaven (2) were isolated from the roots of Glycyrrhiza iconica together with four known ones namely (3S)-licoricidin (3), licorisoflavan A (4), Topazolin (5) and glycycoumarin (6). The structures were elucidated on the basis of extensive spectroscopic analysis including 1D and 2D NMR as well as HR-MS. Furthermore, the absolute configurations of compounds 1, 3 and 4 were established by electronic circular dichroism (ECD). All the isolated compounds (1-6) were evaluated for their in vitro antimicrobial activities against five pathogenic bacteria and one yeast (Candida albicans) using an in vitro microdilution method.
CONCLUSIONS:
Compounds 1 and 3-5 displayed significant activity against Salmonella typhimurium ATCC 13311 with MIC values ranging from 2 to 8 μg/mL. Additionally, all compounds were screened for their in vitro free radical scavenging activities using an in vitro microdilution DPPH assay spectrofotometrically. The tested compounds exhibited IC50 values in the range of 0.18-0.56 mg/mL, suggesting an activity comparable with that of ascorbic acid (IC50: 0.07 mg/mL). To the best of our knowledge, the present study constitutes the first phytochemical and bioactivity investigation on G. iconica.

Maackiaflavanone Description

Source:	The stem barks of Maackia amurensis.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Maackiaflavanone
Price:
CAS No.:	156162-10-6
Catalog No.:	CFN96521
Molecular Formula:	C₂₆H₃₀O₆
Molecular Weight:	438.51 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The stem barks of Maackia amurensis.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Cytotoxic Compound Library Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2804 mL	11.4022 mL	22.8045 mL	45.609 mL	57.0112 mL
5 mM	0.4561 mL	2.2804 mL	4.5609 mL	9.1218 mL	11.4022 mL
10 mM	0.228 mL	1.1402 mL	2.2804 mL	4.5609 mL	5.7011 mL
50 mM	0.0456 mL	0.228 mL	0.4561 mL	0.9122 mL	1.1402 mL
100 mM	0.0228 mL	0.114 mL	0.228 mL	0.4561 mL	0.5701 mL

CFN92695	Sanggenol A	174423-30-4	424.5	C₂₅H₂₈O₆
CFN97979	Sanggenon N	92280-12-1	422.5	C₂₅H₂₆O₆
CFN93042	Glabrol	59870-65-4	392.49	C₂₅H₂₈O₄
CFN92669	Euchrestaflavanone A	80510-05-0	408.5	C₂₅H₂₈O₅
CFN92667	Euchrenone A10	171828-81-2	406.5	C₂₅H₂₆O₅
CFN96525	Euchrestaflavanone B	87402-91-3	424.49	C₂₅H₂₈O₆
CFN96521	Maackiaflavanone	156162-10-6	438.51	C₂₆H₃₀O₆
CFN96511	Abyssinone V	77263-11-7	408.49	C₂₅H₂₈O₅
CFN94881	(-)-Sophoranone	23057-55-8	460.6	C₃₀H₃₆O₄
CFN96529	5-Hydroxysophoranone	90686-12-7	476.61	C₃₀H₃₆O₅