Science | Nature | Cell | View More
Natural Products
Methylophiopogonanone B
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Methylophiopogonanone B
Price: $268 / 20mg
CAS No.: 74805-91-7
Catalog No.: CFN98596
Molecular Formula: C19H20O5
Molecular Weight: 328.36 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The roots of Ophiopogon japonicus
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $71.1 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Tokyo Woman's Christian University (Japan)
  • Universidad Industrial de Santa... (Colombia)
  • Institute of Bioorganic Chemist... (Poland)
  • Massachusetts General Hospital (USA)
  • Mendel University in Brno (Czech Republic)
  • University of Brasilia (Brazil)
  • Kyoto University (Japan)
  • Vin?a Institute of Nuclear Scie... (Serbia)
  • Universiti Sains Malaysia (Malaysia)
  • Semmelweis Unicersity (Hungary)
  • Universidade Federal de Santa C... (Brazil)
  • More...
Package
Featured Products
Hinokiflavone

Catalog No: CFN92007
CAS No: 19202-36-9
Price: $288/20mg
Protodioscin

Catalog No: CFN99517
CAS No: 55056-80-9
Price: $50/20mg
(Z)-Aldosecologanin (Centauroside)

Catalog No: CFN95079
CAS No: 82474-97-3
Price: $388/5mg
Parishin B

Catalog No: CFN93113
CAS No: 174972-79-3
Price: $80/20mg
5-O-Feruloylquinic acid

Catalog No: CFN92889
CAS No: 40242-06-6
Price: $318/10mg
Lycopene

Catalog No: CFN98588
CAS No: 502-65-8
Price: $ / mg
Sesamin

Catalog No: CFN97034
CAS No: 607-80-7
Price: $40/20mg
Petunidin-3-O-glucoside chloride

Catalog No: CFN92043
CAS No: 6988-81-4
Price: $318/5mg
Tilianin

Catalog No: CFN92764
CAS No: 4291-60-5
Price: $218/20mg
Astragaloside III

Catalog No: CFN99174
CAS No: 84687-42-3
Price: $268/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Methylophiopogonanone B has inhibition of hypoxia-inducible factor (HIF)-1 alpha activity.Methylophiopogonanone B can inhibit melanosome transfer to keratinocytes as well as melanocyte dendrite outgrowth, it also suppress pigmentation in a three-dimensional skin culture model through the inhibition of melanocyte dendrite outgrowth, it could result in the creation of very unique cosmetic products that would precisely control the darkening or lightening of skin tone.
Targets: HIF
In vitro:
Mol Cell Biochem. 2007 Mar;297(1-2):121-9.
A novel agent, methylophiopogonanone B, promotes Rho activation and tubulin depolymerization.[Pubmed: 17029007]
Cytoskeletal reorganization, including reconstruction of actin fibers and microtubules, is essential for various biological processes, such as cell migration, proliferation and dendrite formation.
METHODS AND RESULTS:
We show here that Methylophiopogonanone B (MOPB) induces cell morphological change via melanocyte dendrite retraction and stress fiber formation. Since members of the Rho family of small GTP-binding proteins act as master regulators of dendrite formation and actin cytoskeletal reorganization, and activated Rho promotes dendrite retraction and stress fiber formation, we studied the effects of MOPB on the small GTPases using normal human epidermal melanocytes and HeLa cells. In in vitro binding assay, MOPB significantly increased GTP-Rho, but not GTP-Rac or GTP-CDC42. Furthermore, a Rho inhibitor, a Rho kinase inhibitor and a small GTPase inhibitor each blocked MOPB-induced stress fiber formation. The effect of MOPB on actin reorganization was blocked in a Rho dominant negative mutant. These results suggest MOPB acts via the Rho signaling pathway, and it may directly or indirectly activate Rho. Quantitative Western blot analysis indicated that MOPB also induced microtubule destabilization and tubulin depolymerization.
CONCLUSIONS:
Thus, MOPB appears to induce Rho activation, resulting in actin cytoskeletal reorganization, including dendrite retraction and stress fiber formation.
Int.J. Cosmetic Sci., 2006, 28(2):148-148.
Control of melanosome transfer by promoting shrinkage or expansion of melanocyte dendrites.[Reference: WebLink]
Melanosomes synthesized within melanocytes are transferred to keratinocytes through melanocyte dendrites, resulting in a constant supply of melanin to the epidermis which determines skin pigmentation. Theoretically, if we can find an effective way to control this supply of melanin to the epidermis, skin colour could be darkened or lightened.
METHODS AND RESULTS:
The objective of this study was to find safe and effective methods to inhibit or promote melanosome transfer by the shrinkage or expansion of melanocyte dendrites. Methylophiopogonanone B and centaureidin inhibited melanosome transfer to keratinocytes as well as melanocyte dendrite outgrowth. Methylswertianin and comfrey extract promoted not only melanosome transfer to keratinocytes but also expansion of melanocyte dendrites. Methylophiopogonanone B and centaureidin suppressed pigmentation in a three-dimensional skin culture model through the inhibition of melanocyte dendrite outgrowth. Methylswertianin and comfrey extract activated pigmentation in a three-dimensional skin culture model by expansion of melanocyte dendrites.
CONCLUSIONS:
Our experimental findings suggest the possibility of manipulating human skin colour by controlling melanosome transfer to cause shrinkage or expansion of dendrites. A combination of effective agents, in addition to the ones identified in this work, could result in the creation of very unique cosmetic products that would precisely control the darkening or lightening of skin tone.
Methylophiopogonanone B Description
Source: The roots of Ophiopogon japonicus
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Methylgomisin O

Catalog No: CFN95236
CAS No: N/A
Price: $318/5mg
Pd-C-II

Catalog No: CFN95003
CAS No: N/A
Price: $358/5mg
Hosenkoside D

Catalog No: CFN95521
CAS No: 156823-94-8
Price: $318/5mg
2''-O-Galloylmyricitrin

Catalog No: CFN95046
CAS No: 56939-52-7
Price: $333/5mg
Isocucurbitacin D

Catalog No: CFN95326
CAS No: 68422-20-8
Price: $318/5mg
Ampelopsin G

Catalog No: CFN95148
CAS No: 151487-09-1
Price: $318/5mg
Benzyl beta-D-glucopyranoside

Catalog No: CFN95427
CAS No: 4304-12-5
Price: $318/10mg
Naringin 4'-glucoside

Catalog No: CFN95014
CAS No: 17257-21-5
Price: $338/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.0454 mL 15.2272 mL 30.4544 mL 60.9088 mL 76.1359 mL
5 mM 0.6091 mL 3.0454 mL 6.0909 mL 12.1818 mL 15.2272 mL
10 mM 0.3045 mL 1.5227 mL 3.0454 mL 6.0909 mL 7.6136 mL
50 mM 0.0609 mL 0.3045 mL 0.6091 mL 1.2182 mL 1.5227 mL
100 mM 0.0305 mL 0.1523 mL 0.3045 mL 0.6091 mL 0.7614 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Heterocycles, 2009, 78(8):2061-5.
Dihydrochalcone Designed from Methylophiopogonanone B Strongly Inhibits Hypoxia-inducible Factor (HIF)-1α Activity.[Reference: WebLink]
Inhibition of hypoxia-inducible factor (HIF)-1 alpha activity of Methylophiopogonanone B (1) and its derivatives were investigated. As the modification of the structure of 1, dihydrochalcone (11) was leaded and showed one order higher activity (IC(50): 0.2 mu g/mL) than Methylophiopogonanone B (1) (IC(50): 2.2 mu g/mL).
Structure Identification:
Carbohydr Res. 2011 Feb 1;346(2):253-8.
Novel steroidal saponins from Liriope graminifolia (Linn.) Baker with anti-tumor activities.[Pubmed: 21163470]
Phytochemical investigation of the underground parts of Liriope graminifolia (Linn.) Baker resulted in the isolation of two new steroidal saponins lirigramosides A (1) and B (2) along with four known compounds.
METHODS AND RESULTS:
The structures were determined by extensive spectral analysis, including two-dimensional (2D) NMR spectroscopy and chemical methods, to be 3-O-[β-d-xylopyranosyl-(1→3)-α-l-arabinopyranosyl-(1→2)-[α-l-rhamnopyranosyl-(1→4)]-β-d-glucopyranosyl-(25S)-spirost-5-ene-3β,17α-diol (1), 1-O-[α-l-rhamnopyranosyl-(1→2)-β-d-xylopyranosyl]-(25R)-ruscogenin (2), 1-O-β-d-xylopyranosyl-3-O-α-l-rhamnopyranosyl-(25S)-ruscogenin (3), 3-O-α-l-rhamnopyranosyl-1-O-sulfo-(25S)-ruscogenin (4), Methylophiopogonanone B (5), and 5,7-dihydroxy-3-(4-methoxybenzyl)-6-methyl-chroman-4-one, (ophiopogonanone B, 6), respectively. Compound 1 has a new (25S)-spirost-5-ene-3β,17α-diol ((25S)-pennogenin) aglycone moiety.
CONCLUSIONS:
The isolated compounds were evaluated for their cytotoxic activities against Hela and SMMC-7721 cells.
Hinokiflavone

Catalog No: CFN92007
CAS No: 19202-36-9
Price: $288/20mg
Protodioscin

Catalog No: CFN99517
CAS No: 55056-80-9
Price: $50/20mg
(Z)-Aldosecologanin (Centauroside)

Catalog No: CFN95079
CAS No: 82474-97-3
Price: $388/5mg
Parishin B

Catalog No: CFN93113
CAS No: 174972-79-3
Price: $80/20mg
5-O-Feruloylquinic acid

Catalog No: CFN92889
CAS No: 40242-06-6
Price: $318/10mg
Lycopene

Catalog No: CFN98588
CAS No: 502-65-8
Price: $ / mg
Sesamin

Catalog No: CFN97034
CAS No: 607-80-7
Price: $40/20mg
Petunidin-3-O-glucoside chloride

Catalog No: CFN92043
CAS No: 6988-81-4
Price: $318/5mg
Tilianin

Catalog No: CFN92764
CAS No: 4291-60-5
Price: $218/20mg
Astragaloside III

Catalog No: CFN99174
CAS No: 84687-42-3
Price: $268/20mg
Tags: buy Methylophiopogonanone B | Methylophiopogonanone B supplier | purchase Methylophiopogonanone B | Methylophiopogonanone B cost | Methylophiopogonanone B manufacturer | order Methylophiopogonanone B | Methylophiopogonanone B distributor