Microstegiol | CAS:143246-41-7 | Manufacturer ChemFaces

Microstegiol

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Description:

Migrostegiol has a little activity against B. subtilis.

Targets:

Antifection

In vitro:

Fitoterapia. 2005 Jul;76(5):450-2.

Components and antibacterial activity of the roots of Salvia jaminiana.[Pubmed: 15893885 ]

The acetone extract of the roots of Salvia jaminiana, containing the sterols campestanol, stigmasterol and sitosterol, and five known diterpenoids, ferruginol, cryptanol, 6,7-dehydroroyleanon, 6-hydroxysalvinolone and Microstegiol, remarkably inhibited the growth of Bacillus subtilis, Staphylococcus aureus ATCC 25923 and Streptococcus alpha-hemolitic.

Pharmaceutical Biology, 1999 , 37 (2) :148-151.

Cytotoxic Activity of Diterpenoids Isolated from Salvia hypargeia[Reference: WebLink]

METHODS AND RESULTS:
Ten diterpenoids [6a-hydroxysalvinolone (1), 6- hydroxytaxodone (2), aethiopinone (3), Microstegiol (4), ferruginol (5), saprorthoquinone (6), 11,12-dioxoabieta-8,13-diene (7), taxodione (8), hypargenin A (9), hypargenin D (10)] and three triterpenoids [lupeol 3- acetate, -oleanol 3-acetate and ß-sitosterol] were isolated from the roots of Salvia hypargeia, a plant endemic to Turkey. The crude extract and compounds 1-2, 5-10 were tested against a panel of human cancer cell lines [human breast cancer (BC 1), human lung cancer (LU 2), human colon cancer (COL 2), human epidermoidal carcinoma in mouth (KB), vinblastineresistant KB-VI, hormone-dependent human prostate cancer (LNCaP)] as well as P388 and ASK cells in culture.
CONCLUSIONS:
The crude extract was active in all of the test systems, except KB. Isolates 1 and 8 were also found to mediate a generalized cytotoxic response.

Microstegiol Description

Source:	The roots of Salvia prionitis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Planta Med. 2000 Jun;66(5):458-62.

Antibacterial diterpenes from the roots of Salvia viridis.[Pubmed: 10909268 ]

Three new diterpenes, salviviridinol, viridinol, viridone, five known diterpenes, sugiol, 1-oxoferruginol, ferruginol, aethiopinone and Microstegiol, abietane and rearranged abietane diterpenes were isolated from the roots of Salvia viridis.
METHODS AND RESULTS:
These compounds were assayed against S. aureus ATCC 6538 P, E. coli ATCC 8739, P. mirabilis ATCC 14153, K. pneumonia ATCC 4352, P. aeruginosa ATCC 27853, S. epidermidis ATCC 12228, E. faecalis ATCC 29212 and a yeast C. albicans ATCC 10231.
CONCLUSIONS:
1-Oxoferruginol showed activity against B. subtilis, S. aureus, S. epidermidis and a modest activity against P. mirabilis, migrostegiol had a little activity against B. subtilis. The structures of the compounds were established by 1D and 2D NMR spectroscopic techniques.

Product Name	Microstegiol
Price:
CAS No.:	143246-41-7
Catalog No.:	CFN92180
Molecular Formula:	C₂₀H₂₆O₂
Molecular Weight:	298.4 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The roots of Salvia prionitis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antibacterial Compound Library Diterpenoids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.3512 mL	16.756 mL	33.5121 mL	67.0241 mL	83.7802 mL
5 mM	0.6702 mL	3.3512 mL	6.7024 mL	13.4048 mL	16.756 mL
10 mM	0.3351 mL	1.6756 mL	3.3512 mL	6.7024 mL	8.378 mL
50 mM	0.067 mL	0.3351 mL	0.6702 mL	1.3405 mL	1.6756 mL
100 mM	0.0335 mL	0.1676 mL	0.3351 mL	0.6702 mL	0.8378 mL

CFN96073	Saprirearine	453518-30-4	296.4	C₂₀H₂₄O₂
CFN92186	Salvicine	240423-23-8	330.4	C₂₀H₂₆O₄
CFN92183	Prionoid D	879324-77-3	328.4	C₂₀H₂₄O₄
CFN92247	1-Ketoaethiopinone	105062-36-0	310.4	C₂₀H₂₂O₃
CFN92184	Prionoid E	879324-78-4	326.4	C₂₀H₂₂O₄
CFN92244	12-Hydroxysapriparaquinone	142763-37-9	312.4	C₂₀H₂₄O₃
CFN92176	3-Oxosapriparaquinone	119139-56-9	328.4	C₂₀H₂₄O₄
CFN92245	Prionoid B	879324-75-1	310.4	C₂₀H₂₂O₃
CFN92182	Prionoid C	879324-76-2	310.4	C₂₀H₂₂O₃
CFN92185	Salprionin	171439-43-3	312.4	C₂₀H₂₄O₃