Minimolide F | CAS:1367351-41-4 | Manufacturer ChemFaces

Minimolide F

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Minimolide F Description

Source:	The herbs of Centipeda minima
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Phytochemistry. 2012 Apr;76:133-40.

Supercritical fluid extraction assisted isolation of sesquiterpene lactones with antiproliferative effects from Centipeda minima.[Pubmed: 22277736]

Pseudoguaianolide sesquiterpene lactones minimolide A (1), minimolide B (2), minimolide C (3) and minimolide D (4) and two guaianolide sesquiterpene lactones minimolide E (5) and Minimolide F (6), along with seven known ones (7-13), were isolated from the supercritical fluid extract of Centipeda minima.
METHODS AND RESULTS:
The structures of these compounds were elucidated by extensive spectroscopic methods (IR, UV, HRESIMS, 1D-NMR and 2D-NMR), and the complete structure and stereochemistry of 1 was further confirmed by X-ray diffraction analysis. Compounds 1, 5-8,11 and 13 displayed inhibitory activity against human nasopharyngeal cancer cells (CNE) with IC(50) values ranging from 1.1 to 20.3 μM. Compound 13 containing both α-methylene-γ-lactone and α, β-unsaturated cyclopentenone moieties exhibited even stronger inhibitory activity than that of cisplatin (positive control) through cell cycle arrest at G2/M phase.
CONCLUSIONS:
Isolation of six sesquiterpene lactones from Centipeda minima highlighted the potential of supercritical fluid extraction for enrichment of minor constituents for phytochemical study.

Product Name	Minimolide F
Price:
CAS No.:	1367351-41-4
Catalog No.:	CFN92943
Molecular Formula:	C₁₉H₂₆O₅
Molecular Weight:	334.41 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The herbs of Centipeda minima
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Diterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9903 mL	14.9517 mL	29.9034 mL	59.8068 mL	74.7585 mL
5 mM	0.5981 mL	2.9903 mL	5.9807 mL	11.9614 mL	14.9517 mL
10 mM	0.299 mL	1.4952 mL	2.9903 mL	5.9807 mL	7.4759 mL
50 mM	0.0598 mL	0.299 mL	0.5981 mL	1.1961 mL	1.4952 mL
100 mM	0.0299 mL	0.1495 mL	0.299 mL	0.5981 mL	0.7476 mL

CFN91512	Aromaticin	5945-42-6	246.3	C₁₅H₁₈O₃
CFN91510	8-epi-Helenalin	97643-91-9	262.3	C₁₅H₁₈O₄
CFN91513	Bigelovin	3668-14-2	304.3	C₁₇H₂₀O₅
CFN91511	Carpesiolin	63568-73-0	264.3	C₁₅H₂₀O₄
CFN92985	Tenulin	19202-92-7	306.35	C₁₇H₂₂O₅
CFN80472	Pungiolide A	130395-54-9	508.6	C₃₀H₃₆O₇
CFN91998	2beta-(Isobutyryloxy)florilenalin	94898-78-9	334.41	C₁₉H₂₆O₅
CFN97174	4-Epi-isoinuviscolide	68832-39-3	248.3	C₁₅H₂₀O₃
CFN92943	Minimolide F	1367351-41-4	334.41	C₁₉H₂₆O₅
CFN95509	8-epi-Confertin	110115-60-1	248.3	C₁₅H₂₀O₃