Science | Nature | Cell | View More
Natural Products
Moslosooflavone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Moslosooflavone
Price: $168 / 20mg
CAS No.: 3570-62-5
Catalog No.: CFN98475
Molecular Formula: C17H14O5
Molecular Weight: 298.3 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Yellow powder
Source: The herbs of Mosla soochouensis Matsuda
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $34.9 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Max Rubner-Institut (MRI) (Germany)
  • Molecular Biology Institute of ... (Spain)
  • Mendel University in Brno (Czech Republic)
  • Semmelweis Unicersity (Hungary)
  • Weizmann Institute of Science (Israel)
  • Universiti Malaysia Pahang (Malaysia)
  • Universidade de Franca (Brazil)
  • Massachusetts General Hospital (USA)
  • Charles University in Prague (Czech Republic)
  • Uniwersytet Gdański (Poland)
  • Heinrich-Heine-University Düss... (Germany)
  • More...
Package
Featured Products
Danshensu

Catalog No: CFN99539
CAS No: 22681-72-7
Price: $70/20mg
Pinocembrin 7-O-(3''-galloyl-4'',6...

Catalog No: CFN90881
CAS No: 205370-59-8
Price: $318/20mg
Adenosine

Catalog No: CFN98992
CAS No: 58-61-7
Price: $30/20mg
Cucurbitacin B

Catalog No: CFN99129
CAS No: 6199-67-3
Price: $70/20mg
Poncirin

Catalog No: CFN90448
CAS No: 14941-08-3
Price: $168/20mg
Piperine

Catalog No: CFN99919
CAS No: 94-62-2
Price: $30/20mg
Obtusifolin

Catalog No: CFN90394
CAS No: 477-85-0
Price: $268/20mg
Ganoderic acid C1

Catalog No: CFN92053
CAS No: 95311-97-0
Price: $218/5mg
Betulinic acid

Catalog No: CFN98706
CAS No: 472-15-1
Price: $40/20mg
Atractylenolide III

Catalog No: CFN99946
CAS No: 73030-71-4
Price: $70/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Moslosooflavone has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice. Moslosooflavone significantly inhibits the transcriptional activity of NF-kappaB in LPS/IFN-gamma stimulated RAW 264.7 macrophages.
Targets: NF-kB | IFN-γ | IL Receptor | NO | TNF-α
In vitro:
J Agric Food Chem. 2010 Feb 24;58(4):2505-12.
Anti-inflammatory activity of new compounds from Andrographis paniculata by NF-kappaB transactivation inhibition.[Pubmed: 20085279]
Previous studies showed that the ethyl acetate (EtOAc) fraction of Andrographis paniculata (AP) possessed anti-inflammatory activity. This study further isolated these active compounds from bioactivity-guided chromatographic fractionation and identified eight pure compounds.
METHODS AND RESULTS:
Reporter gene assay indicated that 5-hydroxy-7,8-dimethoxyflavone (1), Moslosooflavone (2), a mix of beta-sitosterol (3a) and stigmasterol (3b), ergosterol peroxide (4), 14-deoxy-14,15-dehydroandrographolide (5), and a new compound, 19-O-acetyl-14-deoxy-11,12-didehydroandrographolide (6a), significantly inhibited the transcriptional activity of NF-kappaB in LPS/IFN-gamma stimulated RAW 264.7 macrophages (P < 0.05). The two most abundant compounds, 14-deoxy-11,12-didehydroandrographolide (7) and andrographolide (8), had less inhibitory activity but exerted greater inhibitory activity by hydrogenation, oxidation, or acetylation to become four derived compounds, 9, 10, 11, and 12. All of the compounds significantly decreased TNF-alpha, IL-6, macrophage inflammatory protein-2 (MIP-2), and nitric oxide (NO) secretions from LPS/IFN-gamma stimulated RAW 264.7 cells. Compounds 5, 11, and 12 exerted the strongest inhibitory effect on NF-kappaB-dependent transactivation in the RAW 264.7 cell, with IC(50) values of 2, 2.2, and 2.4 microg/mL, respectively, providing encouraging results for bioactive compound development.
In vivo:
Zhong Yao Cai. 2015 Jan;38(1):89-92.
Chemical Constituents with Anti-hypoxia Activity from Saussurea involucrata.[Pubmed: 26214875]
To investigate the chemical constituents with anti-hypoxia activity from Saussurea involucrata.
METHODS AND RESULTS:
The chemical constituents, isolated and purified by column chromatography from Saussurea involucrata, were identified by several spectroscopic methods. The anti-hypoxic activities of these compounds were examined using the normobaric hypoxic model of mice. Twelve compounds were isolated from petroleum ether extract of Saussurea involucrata and identified as n-octacosane (1), 1-undecanol (2), heptadecan-l-ol(3), heptacosan-1-ol(4), myristicin (5), apiol(6), β-sitosterol(7), lupeol(8), Moslosooflavone (9), mosloflavone (10), negletein(11), and 5, 6-dihydroxy-7, 8-dimethoxyflavone(12).
CONCLUSIONS:
All compounds except 7 and 8 are isolated from this plant for the first time. Compound 1, 5 and 8 - 12 can significantly prolong the survival time of hypoxic mice.
Moslosooflavone Description
Source: The herbs of Mosla soochouensis Matsuda
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
8-Hydroxy-5,7-dimethoxyflavanone

Catalog No: CFN95580
CAS No: 201230-40-2
Price: $318/5mg
Glucoliquiritin

Catalog No: CFN95011
CAS No: 93446-18-5
Price: $318/10mg
Dehydrojuncusol

Catalog No: CFN95143
CAS No: 117824-04-1
Price: $318/5mg
Decuroside I

Catalog No: CFN95004
CAS No: 96638-79-8
Price: $318/5mg
Methyl ganoderate A

Catalog No: CFN95550
CAS No: 105742-78-7
Price: $413/5mg
N1,N5,N10-(Z)-tri-p-coumaroylsperm...

Catalog No: CFN95253
CAS No: 131086-78-7
Price: $238/5mg
1,2-Epoxy-10(14)-furanogermacren-6...

Catalog No: CFN95214
CAS No: 383368-24-9
Price: $318/10mg
Apigenin-8-C-beta-D-glucopyranosyl...

Catalog No: CFN95548
CAS No: N/A
Price: $368/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.3523 mL 16.7616 mL 33.5233 mL 67.0466 mL 83.8082 mL
5 mM 0.6705 mL 3.3523 mL 6.7047 mL 13.4093 mL 16.7616 mL
10 mM 0.3352 mL 1.6762 mL 3.3523 mL 6.7047 mL 8.3808 mL
50 mM 0.067 mL 0.3352 mL 0.6705 mL 1.3409 mL 1.6762 mL
100 mM 0.0335 mL 0.1676 mL 0.3352 mL 0.6705 mL 0.8381 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Nat Prod Commun. 2015 Mar;10(3):387-8.
Convergent synthesis of moslosooflavone, isowogonin and norwogonin from chrysin.[Pubmed: 25924511]
A convergent synthesis route of Moslosooflavone, isowogonin and norwogoninis reported,starting from chrysin, an easily available flavone, by methylation, bromination, methoxylation and demethylation procedures. This synthetic route is convenient and can give the three rare flavones in good yield.
Danshensu

Catalog No: CFN99539
CAS No: 22681-72-7
Price: $70/20mg
Pinocembrin 7-O-(3''-galloyl-4'',6...

Catalog No: CFN90881
CAS No: 205370-59-8
Price: $318/20mg
Adenosine

Catalog No: CFN98992
CAS No: 58-61-7
Price: $30/20mg
Cucurbitacin B

Catalog No: CFN99129
CAS No: 6199-67-3
Price: $70/20mg
Poncirin

Catalog No: CFN90448
CAS No: 14941-08-3
Price: $168/20mg
Piperine

Catalog No: CFN99919
CAS No: 94-62-2
Price: $30/20mg
Obtusifolin

Catalog No: CFN90394
CAS No: 477-85-0
Price: $268/20mg
Ganoderic acid C1

Catalog No: CFN92053
CAS No: 95311-97-0
Price: $218/5mg
Betulinic acid

Catalog No: CFN98706
CAS No: 472-15-1
Price: $40/20mg
Atractylenolide III

Catalog No: CFN99946
CAS No: 73030-71-4
Price: $70/20mg
Tags: buy Moslosooflavone | Moslosooflavone supplier | purchase Moslosooflavone | Moslosooflavone cost | Moslosooflavone manufacturer | order Moslosooflavone | Moslosooflavone distributor