Science | Nature | Cell | View More
Natural Products
Myricanol
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Myricanol
Price:
CAS No.: 33606-81-4
Catalog No.: CFN98430
Molecular Formula: C21H26O5
Molecular Weight: 358.4 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Oil
Source: The root barks of Myrica cerifera L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Universidad de Antioquia (Colombia)
  • National Cancer Center Research... (Japan)
  • University of Liège (Belgium)
  • VIT University (India)
  • Leibniz-Institut für Pflanzenb... (Germany)
  • Kyushu University (Japan)
  • Almansora University (Egypt)
  • Harvard University (USA)
  • Charles University in Prague (Czech Republic)
  • Semmelweis Unicersity (Hungary)
  • University of Hertfordshire (United Kingdom)
  • More...
Package
Featured Products
Quercetin 3-O-rutinoside-(1->2)-O-...

Catalog No: CFN91149
CAS No: 55696-57-6
Price: $318/10mg
Gentiopicroside

Catalog No: CFN98047
CAS No: 20831-76-9
Price: $40/20mg
Glycitein

Catalog No: CFN99106
CAS No: 40957-83-3
Price: $70/20mg
Trans-Ferulic acid

Catalog No: CFN92394
CAS No: 537-98-4
Price: $30/20mg
Betulonic acid

Catalog No: CFN98682
CAS No: 4481-62-3
Price: $40/20mg
2,3,5,4'-Tetrahydroxyl diphenyleth...

Catalog No: CFN99995
CAS No: 82373-94-2
Price: $30/20mg
Guaiol

Catalog No: CFN96326
CAS No: 489-86-1
Price: $ / mg
Scopolamine hydrobromide

Catalog No: CFN99709
CAS No: 114-49-8
Price: $30/20mg
Sennoside A

Catalog No: CFN99903
CAS No: 81-27-6
Price: $40/20mg
Sesamolin

Catalog No: CFN99799
CAS No: 526-07-8
Price: $168/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Myricanol can elicit growth inhibitory and cytotoxic effects on lung cancer cells, it can significantly decelerate tumor growth in vivo by inducing apoptosis.
Targets: Caspase | Bcl-2/Bax | p21 | VEGFR | HIF
In vitro:
Phytomedicine. 2014 Sep 25;21(11):1490-6.
Growth-inhibiting and apoptosis-inducing activities of Myricanol from the bark of Myrica rubra in human lung adenocarcinoma A549 cells.[Pubmed: 24939078 ]
This study investigated whether or not Myricanol extracted from M. rubra bark elicits anti-cancer effects on human lung adenocarcinoma A549 cells by inducing apoptosis in vivo.
METHODS AND RESULTS:
Myricanol was extracted from M. rubra bark through system solvent extraction and silica gel layer column separation. The results of tritiated thymidine assay, colony formation assay, and flow cytometry indicated that Myricanol inhibited the growth of A549 cells. The effects of Myricanol on the expression of key apoptosis-related genes in A549 cells were evaluated by quantitative PCR and Western blot analyses. Myricanol significantly inhibited the growth of A549 cells in a dose-dependent manner, with a half maximal inhibitory concentration of 4.85 μg/ml. Myricanol significantly decreased colony formation and induced A549 cell apoptosis. Myricanol upregulated the expression of Caspase-3, Caspase-9, Bax, and p21 and downregulated the expression of Bcl-2 at the mRNA and protein levels.
CONCLUSIONS:
These changes were associated with apoptosis. Based on these results, we propose that Myricanol elicits growth inhibitory and cytotoxic effects on lung cancer cells. Therefore, Myricanol may be a clinical candidate for the prevention and treatment of lung cancer.
ACS Chem Biol. 2015 Apr 17;10(4):1099-109.
Synthesis, stereochemical analysis, and derivatization of myricanol provide new probes that promote autophagic tau clearance.[Pubmed: 25588114]
We previously discovered that one specific scalemic preparation of Myricanol (1), a constituent of Myrica cerifera (bayberry/southern wax myrtle) root bark, could lower the levels of the microtubule-associated protein tau (MAPT). The significance is that tau accumulates in a number of neurodegenerative diseases, the most common being Alzheimer's disease (AD).
METHODS AND RESULTS:
Herein, a new synthetic route to prepare Myricanol using a suitable boronic acid pinacol ester intermediate is reported. An X-ray crystal structure of the isolated Myricanol (1) was obtained and showed a co-crystal consisting of (+)-aR,11S-Myricanol (2) and (-)-aS,11R-Myricanol (3) coformers. Surprisingly, 3, obtained from chiral separation from 1, reduced tau levels in both cultured cells and ex vivo brain slices from a mouse model of tauopathy at reasonable mid-to-low micromolar potency, whereas 2 did not. SILAC proteomics and cell assays revealed that 3 promoted tau degradation through an autophagic mechanism, which was in contrast to that of other tau-lowering compounds previously identified by our group.
CONCLUSIONS:
During the course of structure-activity relationship (SAR) development, we prepared compound 13 by acid-catalyzed dehydration of 1. 13 had undergone an unexpected structural rearrangement through the isoMyricanol substitution pattern (e.g., 16), as verified by X-ray structural analysis. Compound 13 displayed robust tau-lowering activity, and, importantly, its enantiomers reduced tau levels similarly.
Myricanol Description
Source: The root barks of Myrica cerifera L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Isosilychristin

Catalog No: CFN95369
CAS No: 77182-66-2
Price: $318/5mg
Caffeic acid 4-O-glucuronide

Catalog No: CFN95382
CAS No: 1093679-71-0
Price: $/mg
Complanatoside C

Catalog No: CFN95144
CAS No: N/A
Price: $318/5mg
11-Oxomogroside IIA2

Catalog No: CFN95305
CAS No: 2170761-37-0
Price: $368/5mg
6'-Feruloylnodakenin

Catalog No: CFN95202
CAS No: 131623-14-8
Price: $318/10mg
Physalin O

Catalog No: CFN95097
CAS No: 120849-18-5
Price: $413/5mg
6-Hydroxy-7-methoxydihydroligustil...

Catalog No: CFN95289
CAS No: 210036-09-2
Price: $318/5mg
Epimedin B1

Catalog No: CFN95017
CAS No: 133137-58-3
Price: $268/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.7902 mL 13.9509 mL 27.9018 mL 55.8036 mL 69.7545 mL
5 mM 0.558 mL 2.7902 mL 5.5804 mL 11.1607 mL 13.9509 mL
10 mM 0.279 mL 1.3951 mL 2.7902 mL 5.5804 mL 6.9754 mL
50 mM 0.0558 mL 0.279 mL 0.558 mL 1.1161 mL 1.3951 mL
100 mM 0.0279 mL 0.1395 mL 0.279 mL 0.558 mL 0.6975 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Animal Research:
Int J Mol Sci. 2015 Jan 26;16(2):2717-31.
Myricanol induces apoptotic cell death and anti-tumor activity in non-small cell lung carcinoma in vivo.[Pubmed: 25629230]
This study explored the inhibiting effect and mechanism of Myricanol on lung adenocarcinoma A549 xenografts in nude mice.
METHODS AND RESULTS:
Forty nude mice with subcutaneous A549 xenografts were randomly divided into five groups: high-dose Myricanol (40 mg/kg body weight) group; middle-dose Myricanol (20 mg/kg body weight) group; low-dose Myricanol (10 mg/kg body weight) group; polyethylene glycol 400 vehicle group (1 mL/kg); and tumor model group. Nude mice were sacrificed after 14 days of treatment and the tumor inhibition rate (TIR, %) was then calculated. The relative mRNA expression levels of Bax, Bcl-2, VEGF, HIF-1α, and survivin in the tumor tissues were determined by real-time PCR. TUNEL assay was applied to determine cellular apoptosis, while IHC test was performed to detect the protein expression levels of Bax, Bcl-2, VEGF, HIF-1α, and survivin. The TIR of the three Myricanol-treated groups ranged from 14.9% to 38.5%. The IHC results showed that the protein expression of Bcl-2, VEGF, HIF-1α, and survivin were consistently downregulated, whereas that of Bax was upregulated after Myricanol treatment. Myricanol also significantly upregulated the mRNA expression of Bax and downregulated that of Bcl-2, VEGF, HIF-1α, and survivin in a dose-dependent manner (p < 0.05 to 0.001).
CONCLUSIONS:
These results are consistent with those of IHC. The TUNEL assay results indicated that apoptotic-positive cells significantly increased in the Myricanol-treated tumor tissues compared with the cells of the vehicle control group (p < 0.01 to 0.001). These data suggest that Myricanol could significantly decelerate tumor growth in vivo by inducing apoptosis.
Quercetin 3-O-rutinoside-(1->2)-O-...

Catalog No: CFN91149
CAS No: 55696-57-6
Price: $318/10mg
Gentiopicroside

Catalog No: CFN98047
CAS No: 20831-76-9
Price: $40/20mg
Glycitein

Catalog No: CFN99106
CAS No: 40957-83-3
Price: $70/20mg
Trans-Ferulic acid

Catalog No: CFN92394
CAS No: 537-98-4
Price: $30/20mg
Betulonic acid

Catalog No: CFN98682
CAS No: 4481-62-3
Price: $40/20mg
2,3,5,4'-Tetrahydroxyl diphenyleth...

Catalog No: CFN99995
CAS No: 82373-94-2
Price: $30/20mg
Guaiol

Catalog No: CFN96326
CAS No: 489-86-1
Price: $ / mg
Scopolamine hydrobromide

Catalog No: CFN99709
CAS No: 114-49-8
Price: $30/20mg
Sennoside A

Catalog No: CFN99903
CAS No: 81-27-6
Price: $40/20mg
Sesamolin

Catalog No: CFN99799
CAS No: 526-07-8
Price: $168/20mg
Tags: buy Myricanol | Myricanol supplier | purchase Myricanol | Myricanol cost | Myricanol manufacturer | order Myricanol | Myricanol distributor