N-Methylcalycinine | CAS:86537-66-8 | Manufacturer ChemFaces

N-Methylcalycinine

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Description:

N-Methylcalycinine exhibits potent AChE inhibitory activity.

Targets:

AChR

In vitro:

Fitoterapia. 2015 Jul;104:102-7.

Proaporphine and aporphine alkaloids with acetylcholinesterase inhibitory activity from Stephania epigaea.[Pubmed: 26028544]

METHODS AND RESULTS:
An unusual proaporphine alkaloid bearing an isopropanenitrile group at isoquinoline nitrogen, named epiganine A (1) and a new aporphine alkaloid, epiganine B (2), together with eight known alkaloids, pronuciferine (3), dehydrodicentrine (4), romerine (5), romeline (6), N-Methylcalycinine (7), phanostenine (8), dicentrine (9), and N-methyllaurotetanine (10), were isolated from the roots of Stephania epigaea. The absolute configuration of 1 was determined by calculating electronic circular dichroism (ECD) and comparing with experimental data.
CONCLUSIONS:
Compounds 2 and 4 showed strong acetylcholinesterase (AChE) inhibitory effects with the IC50 values of 4.36 and 2.98μM, respectively. Compounds 5-9 also exhibited potent AChE inhibitory activities.

N-Methylcalycinine Description

Source:	The roots of Stephania epigaea
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	N-Methylcalycinine
Price:
CAS No.:	86537-66-8
Catalog No.:	CFN97425
Molecular Formula:	C₁₉H₁₉NO₄
Molecular Weight:	325.4 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The roots of Stephania epigaea
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticholinesterase Compound Library Alkaloids Compound Library AChR Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0731 mL	15.3657 mL	30.7314 mL	61.4628 mL	76.8285 mL
5 mM	0.6146 mL	3.0731 mL	6.1463 mL	12.2926 mL	15.3657 mL
10 mM	0.3073 mL	1.5366 mL	3.0731 mL	6.1463 mL	7.6829 mL
50 mM	0.0615 mL	0.3073 mL	0.6146 mL	1.2293 mL	1.5366 mL
100 mM	0.0307 mL	0.1537 mL	0.3073 mL	0.6146 mL	0.7683 mL

CFN98275	Crebanine	25127-29-1	339.4	C₂₀H₂₁NO₄
CFN98828	Stephanine	517-63-5	309.4	C₁₉H₁₉NO₃
CFN96770	O-Nornuciferine	3153-55-7	281.35	C₁₈H₁₉NO₂
CFN99733	Nuciferine	475-83-2	295.38	C₁₉H₂₁NO₂
CFN96064	N-Methylnuciferine	754919-24-9	310.4	C₂₀H₂₄NO₂
CFN96772	Asimilobine	6871-21-2	267.32	C₁₇H₁₇NO₂
CFN96149	N-Nornuciferine	4846-19-9	281.4	C₁₈H₁₉NO₂
CFN91037	Lirinidine	54383-28-7	281.4	C₁₈H₁₉NO₂
CFN90406	Dehydroglaucine	22212-26-6	353.41	C₂₁H₂₃NO₄
CFN97265	Dehydrocrebanine	77784-22-6	337.4	C₂₀H₁₉NO₄