| Structure Identification: |
| Chinese Traditional & Herbal Drugs, 2012, 43(8):1462-1470. | | Studies on chemical constituents from Aidi Injection.[Reference: WebLink] |
To investigate the chemical constituents from Aidi Injection.
METHODS AND RESULTS:
The chemical constituents were isolated by chromatography on Sephadex LH-20 gel columns and reverse phase semi-preparation HPLC repeatedly, and their structures were identified by spectral data. Twenty-two compounds were isolated and identified as 3-O-(3', 4'-diacetyl)-β-D-xylopyranosyl-6-O-β - D-glucopyranosyl-cycloastragenol (1), astragaloside IV (2), astragaloside II (3), astragaloside I (4), isoastragaloside I (5), acetylastragaloside I (6), ginsenosid-Re (7), ginsenoside-Rf (8), ginsenoside-Rg 1 (9), ginsenoside-Rb 3 (10), notoginsenoside-R 4 (11), ginsenoside-Rb 1 (12), ginsenoside-Rc (13), ginsenoside-Rb 2 (14), ginsenoside-Rd (15), lucyoside H (16), 3-O-β-D-glucopyranosyl (1→4)-β-D-glucopyranosyl (1→3)-α-L-rhamnopyranosyl (1→2) - α-L-arabinopyranosyl oleanolic acid 28-O-α-L-rhamnopyranosyl (1→4)-β-D-glucopyranosyl (1→6)-β - D-glucopyranoside (17), 3-O-β-D-glucopyranosyl (1→3)-α-L-rhamno-pyranosyl [β-D-glucopyranosyl-(1→4)]-(1→2)-α - L-arabinopyranosyl oleanolic acid 28-O-α-L-arabinopyranosyl (1→4)-β-D-gluco-pyranosyl (1→6)-β - D-glucopyranoside (18), syringin (19), elentheroside E (20), 4-(1, 2, 3-trihydroxypropyl)-2, 6-dimethoxyphenyl-1-O-β-D-glucopyranoside (21), and coniferin (22).
CONCLUSIONS:
LC-MS analysis shows that compounds 1-6 are originated from Astragalus membranceus, compounds 7-18 from Panax ginseng, and compounds 19-22 from Acanthopanacis senticosi. Compound 1 is a new compound named Neoastragaloside I.
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