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Neotriptophenolide
Neotriptophenolide
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Neotriptophenolide
Price:
CAS No.: 81827-74-9
Catalog No.: CFN91913
Molecular Formula: C21H26O4
Molecular Weight: 342.43 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The roots of Tripterygium wilfordii
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Reference standards.
Neotriptophenolide Description
Source: The roots of Tripterygium wilfordii
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9203 mL 14.6015 mL 29.203 mL 58.4061 mL 73.0076 mL
5 mM 0.5841 mL 2.9203 mL 5.8406 mL 11.6812 mL 14.6015 mL
10 mM 0.292 mL 1.4602 mL 2.9203 mL 5.8406 mL 7.3008 mL
50 mM 0.0584 mL 0.292 mL 0.5841 mL 1.1681 mL 1.4602 mL
100 mM 0.0292 mL 0.146 mL 0.292 mL 0.5841 mL 0.7301 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Asian Nat Prod Res. 2012;14(10):973-80.
Two sesquiterpene pyridine alkaloids and a triterpenoid saponin from the root barks of Tripterygium hypoglaucum.[Pubmed: 23046469 ]

METHODS AND RESULTS:
Two new sesquiterpene pyridine alkaloids hypoglaunines E (1) and F (2) and a new triterpenoid saponin hypoglaside A (3), together with a known diterpenoid glucoside11-O-β-D-glucopyranosyl Neotriptophenolide (4) and two known triterpenoids 23-noroxopristimerol(5) and 2,3-dihydroxy-6-oxo-D:A-froedo-24 nor-1,3,5(10),7-oleanatetraen-29-oic acid (6), have been isolated from the root barks of Tripterygiumhypoglaucum. Their structures were elucidated by NMR spectroscopy and MS analysis.
CONCLUSIONS:
Compounds 1–3 were screened for their cytotoxic activities against five cancer celllines, but all of them were inactive.
CFN91917Triptobenzene K198129-88-3342.39C20H22O5
CFN91913Neotriptophenolide81827-74-9342.43C21H26O4
CFN91912Triptohairic acid220209-71-2328.45C21H28O3
CFN99474Triptoquinone B142937-50-6330.4 C20H26O4
CFN96475Triptoquinone A142950-86-5328.40C20H24O4
CFN96479Triptinin B189389-05-7314.42C20H26O3
CFN96478Triptobenzene H146900-55-2344.45C21H28O4
CFN91646Triptonoterpene99694-87-8300.4C20H28O2
CFN99197Tripdiolide38647-10-8376.40C20H24O7
CFN99134Triptonide38647-11-9358.39C20H22O6
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