|Source:||Found in citrus, kumquat and pummelo peel oils, ginger, cardamon, clary sage and myrtle.|
|Biological Activity or Inhibitors:||1. Nerylacetate and 1,5-dienes geranyl acetate are catalyzed to the cis-2,5-bis(hydroxymethyl)tetrahydrofurans 3 and 4 by OsO4.
|Solvent:||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||5.0942 mL||25.4712 mL||50.9424 mL||101.8849 mL||127.3561 mL|
|5 mM||1.0188 mL||5.0942 mL||10.1885 mL||20.377 mL||25.4712 mL|
|10 mM||0.5094 mL||2.5471 mL||5.0942 mL||10.1885 mL||12.7356 mL|
|50 mM||0.1019 mL||0.5094 mL||1.0188 mL||2.0377 mL||2.5471 mL|
|100 mM||0.0509 mL||0.2547 mL||0.5094 mL||1.0188 mL||1.2736 mL|
Tetrahedron Letters, 1998 , 39 (52) :9781-4.
|OsO4-Catalyzed oxidative cyclization of geranyl and neryl acetate to cis-2,5-bis(hydroxymethyl)tetrahydrofurans[Reference: WebLink]|
|OsO4 catalyzes the oxidative cyclization of the 1,5-dienes geranyl acetate (1) and Nerylacetate (2) to the cis-2,5-bis(hydroxymethyl)tetrahydrofurans 3 and 4 respectively, in the presence of NaIO4 as cooxidant in DMF. The reaction is stereospecific and proceeds with the sequential syn addition to both double bonds of the starting materials. The observed stereoselectivity can be explained by invoking the intermediacy of a square-based pyramidal osmium (VI) diester (5) that has been isolated and characterized. Evidence is reported that this substance is indeed an intermediate in the transformation of 1 to 3.|